From Robust Synthetic Biological Parts to Whole Systems: Theoretical Practical and Ethical Challenges
从稳健的合成生物部件到整个系统:理论、实践和伦理挑战
基本信息
- 批准号:BB/F018479/1
- 负责人:
- 金额:$ 13.76万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2008
- 资助国家:英国
- 起止时间:2008 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. Therefore this poses a challenge to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate in uncertain environments in a robust way and therefore have a lot to contribute towards this major challenge in Synthetic Biology: how to construct biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. The proposed network in Synthetic Biology will bring together people working in Synthetic and Systems Biology as well as systems/control, electrical, chemical and computer engineers, physicists and mathematicians to address the theoretical and practical challenges of creating robust biological networks that can function inside uncertain biological environments, all the way from parts to whole systems. The network will also focus on ethical, societal and economical concerns that are raised by advances in Synthetic Biology, creating a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup and fuel generation. Legal and other measures that need to be taken in order to ensure that Synthetic Biology research outcomes are not used against society and risk safety of the social structure will be proposed.
合成生物学是一个新的研究领域,其目的是设计新的或修改现有的生物途径,以产生具有上级或不同性质的系统,通常用于新的应用。在系统生物学的相关领域,人们认识到,仅仅通过列出其组件来推断生物网络行为是不可能的,而是需要考虑连接它们的整个反馈机制;在每一个合成生物学设计中也是如此。然而,这些设计需要在细胞环境中实施,合成生物学必须面对的一个主要挑战是,在设计或重新设计过程中需要考虑新途径与细胞环境相互作用的影响。这不同于任何其他工程设计过程,例如电路或计算机工程设计,其中简单部件的行为(例如,电阻器),更复杂的部件(例如,晶体管)或甚至整个系统(例如,完整的电路)可以在实现之后被有效地预测(并且最终被测量和验证)。因此,这对工程和数学提出了挑战。与此同时,许多工程学科,如控制和计算机工程,多年来一直在处理复杂系统的分析和设计,这些系统必须在不确定的环境中以稳健的方式运行,因此对合成生物学的这一重大挑战做出了很大贡献:如何构建生物模块,无论是部件、通路、人工细胞还是在不确定环境中具有性能保证的培养物/组织。拟议的合成生物学网络将汇集合成和系统生物学工作人员以及系统/控制,电气,化学和计算机工程师,物理学家和数学家,以解决创建强大的生物网络的理论和实践挑战,这些网络可以在不确定的生物环境中发挥作用,从部分到整个系统。该网络还将关注合成生物学进步所引发的伦理、社会和经济问题,并就如何通过许多应用的潜在有用性(如环境清理和燃料生产)来平衡这些问题进行富有成效的讨论。将提出需要采取的法律的和其他措施,以确保合成生物学研究成果不被用于危害社会和社会结构的风险安全。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Engineering and ethical perspectives in synthetic biology. Rigorous, robust and predictable designs, public engagement and a modern ethical framework are vital to the continued success of synthetic biology.
- DOI:10.1038/embor.2012.81
- 发表时间:2012-06-29
- 期刊:
- 影响因子:7.7
- 作者:Anderson, James;Strelkowa, Natalja;Stan, Guy-Bart;Douglas, Thomas;Savulescu, Julian;Barahona, Mauricio;Papachristodoulou, Antonis
- 通讯作者:Papachristodoulou, Antonis
A single phosphatase can convert a robust step response into a graded, tunable or adaptive response
- DOI:10.1099/mic.0.066324-0
- 发表时间:2013-07-01
- 期刊:
- 影响因子:2.8
- 作者:Chang, Yo-Cheng;Armitage, Judith P.;Wadhams, George H.
- 通讯作者:Wadhams, George H.
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Antonis Papachristodoulou其他文献
A linear multi-agent systems approach to diffusively coupled piecewise affine systems : delay robustness
扩散耦合分段仿射系统的线性多智能体系统方法:延迟鲁棒性
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Kenji Kashima;Antonis Papachristodoulou;Frank Allgower - 通讯作者:
Frank Allgower
Probabilistic feasibility guarantees for convex scenario programs with an arbitrary number of discarded constraints
- DOI:
10.1016/j.automatica.2022.110601 - 发表时间:
2023-03-01 - 期刊:
- 影响因子:
- 作者:
Licio Romao;Kostas Margellos;Antonis Papachristodoulou - 通讯作者:
Antonis Papachristodoulou
Data-Driven Stable Neural Feedback Loop Design
数据驱动的稳定神经反馈环路设计
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Zuxun Xiong;Han Wang;Liqun Zhao;Antonis Papachristodoulou - 通讯作者:
Antonis Papachristodoulou
Connection profile robustness in a heterogeneous network of piecewise affine FitzHugh-Nagumo models
分段仿射 FitzHugh-Nagumo 模型异构网络中连接配置文件的鲁棒性
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Kenji Kashima;Antonis Papachristodoulou;Frank Allgower - 通讯作者:
Frank Allgower
Distributed safe control design and probabilistic safety verification for multi-agent systems
多智能体系统的分布式安全控制设计与概率安全验证
- DOI:
10.1016/j.automatica.2025.112393 - 发表时间:
2025-09-01 - 期刊:
- 影响因子:5.900
- 作者:
Han Wang;Antonis Papachristodoulou;Kostas Margellos - 通讯作者:
Kostas Margellos
Antonis Papachristodoulou的其他文献
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{{ truncateString('Antonis Papachristodoulou', 18)}}的其他基金
Engineering Fellowships For Growth: Designing Feedback Control in Biology for Robustness and Scalability
增长工程奖学金:设计生物学中的反馈控制以实现鲁棒性和可扩展性
- 批准号:
EP/M002454/1 - 财政年份:2015
- 资助金额:
$ 13.76万 - 项目类别:
Fellowship
Sum-of-Squares Approach to Global Stability and Control of Fluid Flows
流体流动全局稳定性和控制的平方和方法
- 批准号:
EP/J010537/1 - 财政年份:2013
- 资助金额:
$ 13.76万 - 项目类别:
Research Grant
Control Engineering Inspired Design Tools for Synthetic Biology
受控制工程启发的合成生物学设计工具
- 批准号:
EP/I031944/1 - 财政年份:2011
- 资助金额:
$ 13.76万 - 项目类别:
Research Grant
Control Theory Tools for Eludicating the Phosphotransfer Network in Rhodobacter Sphaeroides: A Feasibility Study
阐明球形红杆菌磷酸转移网络的控制理论工具:可行性研究
- 批准号:
EP/E05708X/1 - 财政年份:2007
- 资助金额:
$ 13.76万 - 项目类别:
Research Grant
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使用合成细胞工程生物信号通路 (SIGSYNCELL)
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SIGSYNCELL: Engineering biological signaling pathways using synthetic cells
SIGSYNCELL:使用合成细胞工程生物信号通路
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- 批准号:
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Iron-sulfur Clusters as Biological Sensors: Mechanistic Investigations by Synthetic Modeling Studies
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