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CENTER FOR STUDY OF REPRODUCTIVE BIOLOGY AND DISEASE

生殖生物学和疾病研究中心

基本信息

批准号：
6636782
负责人：
PAMELA L MELLON
金额：
$ 150.9万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
起止时间：
1978-12-01 至 2005-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6636782
关键词：
gonadotropin releasing factor hormone regulation /control mechanism menstrual cycle

项目摘要

The goal of the Center for the Study of Reproductive Biology and Disease will be do develop understanding of the mechanisms which govern normal and disordered function of the hypothalamic-pituitary- ovarian axis. We will continue to produce novel and important contributions os the reproductive sciences, integrating multi- disciplinary clinical and basic research to facilitate and accelerate the translation of promising new discoveries into clinical medicine. We have chosen five innovative research projects, all with experienced, internationally renowned leaders. Research project 11 will investigate the molecular mechanisms of gene regulation in the gonadotrope with specific focus on responses to GnRH and the activin/follistatin system and their interactions. Research project 12 will chart new territory in the role of the oocyte in follicular maturation studying GDF-9 in both rat and human ovaries. Research Project 13 will provide detailed molecular understanding of the signal transduction cascade of GnRH. Analyses will include the roles of G proteins both alpha and Betagamma subunits, the role of MAP kinase and ras, and differential use signaling pathways for various actions of GnRH in the gonadotrope. Research Project 14 will investigate the roles of the Bone Morphogenetic Proteins, members of the TGF-Beta superfamily, in ovarian physiology. Emphasis will be placed on testing the new hypothesis that BMPs are luteinization inhibitors and their activities are regulated by follistatin. Analyses will include cultured rat and human granulosa cells and rats in vivo. Research project 15 will focus on the influence of insulin in the endocrine control of LH release and steroid synthesis by the ovarian granulosa and theca compartments in vivo in normal women and patients with polycytic ovary syndrome. Two closed Cored are proposed: the Administrative Core and the Recombinant Protein Core. The Administrative Core will provide administrative, fiscal, planning and meeting services and administer the Enrichment Program. The Recombinant Protein Core will meet the needs of the Research Projects for production, purification and characterization of proteins and antibodies that are unavailable elsewhere. We envision that this integrated research Center will generate a repertoire of discoveries that will provide a comprehensive understanding of the molecules, cells, and systems involved in controlling reproductive function, leading to improved treatment of disease.

生殖生物学和疾病研究中心的目标是加深对控制下丘脑-垂体-卵巢轴正常和紊乱功能的机制的了解。我们将继续在生殖科学领域做出新颖而重要的贡献，整合多学科的临床和基础研究，以促进和加速将有前景的新发现转化为临床医学。我们选择了五个创新研究项目，所有项目均由经验丰富的国际知名领导者参与。研究项目 11 将研究促性腺激素基因调控的分子机制，特别关注对 GnRH 和激活素/卵泡抑素系统的反应及其相互作用。研究项目 12 将绘制卵母细胞在卵泡成熟中的作用的新领域，研究大鼠和人类卵巢中的 GDF-9。研究项目 13 将提供对 GnRH 信号转导级联的详细分子理解。分析将包括 G 蛋白 α 和 Betagamma 亚基的作用、MAP 激酶和 ras 的作用，以及促性腺激素中 GnRH 各种作用的差异使用信号通路。研究项目 14 将研究骨形态发生蛋白（TGF-Beta 超家族成员）在卵巢生理学中的作用。重点将放在检验 BMP 是黄体生成抑制剂且其活性受卵泡抑素调节的新假设上。分析将包括培养的大鼠和人颗粒细胞以及大鼠体内。研究项目15将重点研究胰岛素对正常女性和多细胞卵巢综合征患者体内卵巢颗粒和卵泡膜室LH释放和类固醇合成的内分泌控制的影响。提出了两个封闭核心：管理核心和重组蛋白核心。行政核心将提供行政、财务、规划和会议服务并管理强化计划。重组蛋白核心将满足研究项目对其他地方无法提供的蛋白质和抗体的生产、纯化和表征的需求。我们设想这个综合研究中心将产生一系列的发现，这些发现将提供对控制生殖功能所涉及的分子、细胞和系统的全面了解，从而改善疾病的治疗。