Transgenic approaches to generate influenza virus resistant poultry.

这项研究的长期目标是培育出对禽流感病毒感染具有抵抗力的转基因鸡。实现这一目标的工作已经在进行中，已经开发了两种不同的抑制病毒复制的策略并将其引入鸡体内。目前的赠款申请旨在获得资金，以开发这些战略的更复杂版本。目前的目标是使抑制分子的表达取决于病毒感染。因此，只有在需要的时候才会表达抑制分子。这将避免转基因表达可能对鸟类的整体生产力产生任何不可预见的影响。这将极大地扩大我们可用的抑制方法的范围。这项工作有可能减少禽流感对商业家禽的威胁。这将对粮食安全、该行业的经济安全和动物福利产生明显的好处。它还有可能消除禽流感跨越物种障碍进入人类的桥梁之一。因此，它可以降低在人类身上出现新的大流行流感病毒株的可能性。

The long term goal of this research is to generate transgenic chickens that are resistant to infection by avian influenza virus. Work towards this goal is already underway, and two different strategies to suppress virus replication have been developed and introduced into chickens. This current grant application is intended to secure funding to develop more sophisticated versions of these strategies. The immediate goal is to make the expression of the inhibitory molecules contingent upon virus infection. Thus, the inhibitory molecules would only be expressed when required. This would avoid any unforseen effects that transgene expression might have on the overall productivity of the birds. This will considerably broaden the range of inhibitory approaches available to us. This work has the potential to decrease the avian influenza threat to commercial poultry. This would have obvious benefits for food security, economic security for the industry and animal welfare. It also has the potential to remove one of the bridges by which avian influenza can cross the species barrier into humans. Thus it could reduce the likelihood of the emergence of new pandemic strains of influenza virus in man.