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Transgenic approaches to generate influenza virus resistant poultry.

产生抗流感病毒家禽的转基因方法。

基本信息

批准号：
BB/G00479X/1
负责人：
Laurence Tiley
金额：
$ 38.75万
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FG00479X%2F1
关键词：
Transgenic approaches generate influenza virus

项目摘要

The long term goal of this research is to generate transgenic chickens that are resistant to infection by avian influenza virus. Work towards this goal is already underway, and two different strategies to suppress virus replication have been developed and introduced into chickens. This current grant application is intended to secure funding to develop more sophisticated versions of these strategies. The immediate goal is to make the expression of the inhibitory molecules contingent upon virus infection. Thus, the inhibitory molecules would only be expressed when required. This would avoid any unforseen effects that transgene expression might have on the overall productivity of the birds. This will considerably broaden the range of inhibitory approaches available to us. This work has the potential to decrease the avian influenza threat to commercial poultry. This would have obvious benefits for food security, economic security for the industry and animal welfare. It also has the potential to remove one of the bridges by which avian influenza can cross the species barrier into humans. Thus it could reduce the likelihood of the emergence of new pandemic strains of influenza virus in man.

这项研究的长期目标是培育出能够抵抗禽流感病毒感染的转基因鸡。实现这一目标的工作已经在进行中，已经开发出两种不同的抑制病毒复制的策略并将其引入鸡体内。这项目前的奖助金申请是为了确保经费，以发展这些策略更精密的版本。当前的目标是使抑制分子的表达随病毒感染而变化。因此，抑制分子只会在需要时表达。这将避免任何不可预见的影响，转基因表达可能对鸟类的整体生产力。这将大大拓宽我们可用的抑制方法的范围。这项工作有可能减少禽流感对商品家禽的威胁。这对食品安全、工业经济安全和动物福利都有明显的好处。它也有可能消除禽流感跨越物种屏障进入人类的一座桥梁。因此，它可以减少在人类中出现新的流感大流行病毒株的可能性。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transgenic animals resistant to infectious diseases.

DOI：
10.20506/rst.35.1.2422
发表时间：
2016-04
期刊：
Revue scientifique et technique
影响因子：
0
作者：
L. Tiley
通讯作者：
L. Tiley

Adaptation of avian influenza virus to a swine host.

DOI：
10.1093/ve/vex007
发表时间：
2017-01
期刊：
Virus evolution
影响因子：
5.3
作者：
Bourret V;Lyall J;Frost SDW;Teillaud A;Smith CA;Leclaire S;Fu J;Gandon S;Guérin JL;Tiley LS
通讯作者：
Tiley LS

Efficient Bayesian Model Choice for Partially Observed Processes: With Application to an Experimental Transmission Study of an Infectious Disease

部分观察过程的有效贝叶斯模型选择：应用于传染病的实验传播研究