Effects of bone tissue mineral and matrix properties on fracture incidence
骨组织矿物质和基质特性对骨折发生率的影响
基本信息
- 批准号:7479452
- 负责人:
- 金额:$ 4.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-29 至 2011-09-28
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeBiopsyBone DiseasesBone TissueDiseaseElectronsFractureGoalsHumanImageIncidenceLogistic RegressionsMeasuresMethodsMineralsMolecular StructureOsteoporosisPathologyPatientsPharmacotherapyPlayPreventionPropertyProteinsPublic HealthRelative (related person)RiskRisk ReductionRoleSkeletal systemSpatial DistributionSpectrum AnalysisStructureTherapeutic AgentsTissuesWomanbasebisphosphonateboneinsighttomography
项目摘要
DESCRIPTION: Osteoporosis is a major skeletal pathology that not only reduces bone mass but also alters the properties of the constituent tissue. Antiresorptive drug therapies for osteoporosis moderately increase bone mass but substantially decrease fracture risk, suggesting that modified tissue properties may play a key role in fracture risk reduction in osteoporotic patients. The long-term objective of this application is to understand the relationship between bone fragility and disease- and treatment-induced changes in the structure and distribution of bone mineral and matrix. Accordingly, the following Specific Aims are proposed: To relate bone mineral and matrix properties, microarchitecture, and quantity to fracture incidence in (1) young, untreated bone tissue and (2) bone tissue treated with antiresorptive therapeutic agents. In Aim 1 iliac crest biopsies from young women of comparable BMD with and without fractures will be characterized with a) vibrational spectroscopy and backscattered electron imaging to assess mineral and matrix properties and b) microcomputed tomography (microCT) and histomorphometry to assess microarchitecture and bone volume fraction (BV/TV). Relationships among fracture incidence, BMD, mineral and matrix properties, and microarchitectural measures will be examined with a multiple logistic regression. In Aim 2 bisphosphonate-treated and age-matched control human biopsies will be characterized using the same methods described for Aim 1 to assess treatment-based differences in mineral and matrix parameters and microarchitectural measures. As before, the ability of these parameters to predict fracture will be assessed with a logistic regression. These studies will illuminate the relative contributions of mineral and matrix properties, microarchitecture, and bone quantity to fracture incidence in normal and osteoporotic tissue. In addition, they will provide crucial insights into the mechanisms by which osteoporosis increases bone fragility and by which bisphosphonates reduce fracture incidence in osteoporotic tissue. Relevance to Public Health: The goal of this study is to understand how changes in the molecular structure and spatial distribution of the mineral and protein in bone tissue affect the likelihood that it will fracture. Understanding the factors that contribute to skeletal fragility is essential for effective prevention and treatment of bone diseases like osteoporosis.
描述:骨质疏松症是一种主要的骨骼病理学,不仅可以减少骨骼质量,还会改变组成组织的特性。用于骨质疏松症的抗吸毒药物疗法适度增加骨骼量,但大大降低了骨折风险,这表明修饰的组织特性可能在骨质疏松患者的骨折风险降低中起关键作用。该应用的长期目的是了解骨骼脆弱性与疾病和治疗引起的骨矿物质和基质分布的变化之间的关系。因此,提出了以下特定目的:将骨矿物质和基质特性,微体系结构和数量与(1)年轻,未处理的骨组织中的骨折发生率以及(2)用抗吸收性治疗剂处理的骨组织相关联。在AIM 1中,具有和不骨折的可比BMD的年轻女性的Iliac Crest活检将以A)振动光谱和反向散射的电子成像进行特征,以评估矿物质和基质特性以及B)微型层析成像(Microct)(MicroCT)和组合图,以评估微型胶水量和骨骼体积液体液体胶卷(BV/BV/BV)。骨折发生率,BMD,矿物质和基质特性以及微体系式测度之间的关系将通过多个逻辑回归进行检查。在AIM 2中,双膦酸盐治疗和年龄匹配的对照人的活检将使用AIM 1所描述的相同方法来评估基于治疗的矿物和基质参数和微构造指标的差异。和以前一样,这些参数预测断裂的能力将通过逻辑回归进行评估。这些研究将阐明矿物质和基质特性,微构造以及骨骼数量对正常和骨质疏松组织中断裂发生率的相对贡献。此外,它们将提供有关骨质疏松症增加骨骼脆弱性以及双膦酸盐减少骨质疏松组织中骨折发生率的机制的关键见解。与公共卫生有关:这项研究的目的是了解骨组织中矿物质和蛋白质的分子结构和空间分布的变化如何影响其破裂的可能性。了解导致骨骼脆弱性的因素对于有效预防和治疗骨质疏松症等骨骼疾病至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Eve Donnelly其他文献
Eve Donnelly的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Eve Donnelly', 18)}}的其他基金
Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
2 型糖尿病骨的非酶糖化、骨质量和微损伤
- 批准号:
8815262 - 财政年份:2013
- 资助金额:
$ 4.78万 - 项目类别:
Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
2 型糖尿病骨的非酶糖化、骨质量和微损伤
- 批准号:
8487952 - 财政年份:2013
- 资助金额:
$ 4.78万 - 项目类别:
Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
2 型糖尿病骨的非酶糖化、骨质量和微损伤
- 批准号:
8627548 - 财政年份:2013
- 资助金额:
$ 4.78万 - 项目类别:
Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
2 型糖尿病骨的非酶糖化、骨质量和微损伤
- 批准号:
9017949 - 财政年份:2013
- 资助金额:
$ 4.78万 - 项目类别:
Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
2 型糖尿病骨的非酶糖化、骨质量和微损伤
- 批准号:
9233019 - 财政年份:2013
- 资助金额:
$ 4.78万 - 项目类别:
Effects of bone tissue mineral and matrix properties on fracture incidence
骨组织矿物质和基质特性对骨折发生率的影响
- 批准号:
7616789 - 财政年份:2008
- 资助金额:
$ 4.78万 - 项目类别:
Effects of bone tissue mineral and matrix properties on fracture incidence
骨组织矿物质和基质特性对骨折发生率的影响
- 批准号:
7917377 - 财政年份:2008
- 资助金额:
$ 4.78万 - 项目类别:
相似国自然基金
无线供能边缘网络中基于信息年龄的能量与数据协同调度算法研究
- 批准号:62372118
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
CHCHD2在年龄相关肝脏胆固醇代谢紊乱中的作用及机制
- 批准号:82300679
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
颗粒细胞棕榈酰化蛋白FXR1靶向CX43mRNA在年龄相关卵母细胞质量下降中的机制研究
- 批准号:82301784
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
年龄相关性黄斑变性治疗中双靶向药物递释策略及其机制研究
- 批准号:82301217
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
多氯联苯与机体交互作用对生物学年龄的影响及在衰老中的作用机制
- 批准号:82373667
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
相似海外基金
Cellular mechanisms for the degeneration and aging of human rotator cuff tears
人类肩袖撕裂变性和衰老的细胞机制
- 批准号:
10648672 - 财政年份:2023
- 资助金额:
$ 4.78万 - 项目类别:
DELINEATING THE ROLE OF THE HOMOCYSTEINE-FOLATE-THYMIDYLATE SYNTHASE AXIS AND URACIL ACCUMULATION IN AFRICAN AMERICAN PROSTATE TUMORS
描述同型半胱氨酸-叶酸-胸苷酸合成酶轴和尿嘧啶积累在非裔美国人前列腺肿瘤中的作用
- 批准号:
10723833 - 财政年份:2023
- 资助金额:
$ 4.78万 - 项目类别:
Clinical breast cancer risk prediction models for women with a high-risk benign breast diagnosis
高风险良性乳腺诊断女性的临床乳腺癌风险预测模型
- 批准号:
10719777 - 财政年份:2023
- 资助金额:
$ 4.78万 - 项目类别:
The role of human SLE causal variant NCF1.pR90H in promoting kidney damage
人类SLE致病变异NCF1.pR90H在促进肾脏损伤中的作用
- 批准号:
10740630 - 财政年份:2023
- 资助金额:
$ 4.78万 - 项目类别: