HIPPO MORPHOMETRY IN FRONTOTEMPORAL DEMENTIA: A RADIAL ATROPHY MAPPING STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。背景：在比较FTD和AD患者的研究中反复检测到相似数量的海马萎缩，尽管萎缩变化的分布可能不同。最近的技术，如径向萎缩映射，不仅基于萎缩的绝对数量，而且基于其空间分布，可以表征不同类型痴呆的萎缩变化。方法：在维罗纳大学放射科采集9例FTD患者和27例对照者的MRI图像，使用1.5 Tesla单元（Siemens, Magnetom）和标准头线圈。采用梯度回波3d技术进行图像采集，TR为10 msec；TE 4毫秒；TI 300毫秒；翻转角度10?；视野250毫米；收购2;矩阵160 ? 256年。总采集时间为7:40分钟。MRI图像将使用统计参数映射（SPM99）软件通过线性（12参数）转换归一化到定制模板。海马体将根据一个正式的协议进行手动跟踪，并建立了相互之间和内部的可靠性，并将创建3D参数表面网格模型来表示每个受试者的海马体。为了评估海马形态，将自动定义一条内侧曲线作为每个图像切片中海马边界质心跟踪的3D曲线。通过自动测量从表面点到为个体海马表面模型定义的内侧曲线的径向三维距离，来评估每个边界点上每个海马的径向大小。较短的径向距离将被用作萎缩的指标。将生成统计图，显示局部组海马径向距离的差异。预期结果：实验预测包括检测海马前部大部分区域的萎缩，正如一项基于人工追踪的研究（Laakso et al., 2000）所表明的那样，或者无论如何，在与AD不同的位置，涉及CA1区域和部分背骨。Laakso MP, Frisoni GB, Kononen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ。额颞叶痴呆和阿尔茨海默病的海马和内嗅皮层：一项形态计量MRI研究。精神病学杂志。2000;47:1056-63。弗里索尼GB， Sabattoli F, Lee AD, Dutton RA, Toga AW, Thompson PM。阿尔茨海默病海马形成的体内神经病理学：一项基于磁共振成像的径向定位研究。科学杂志。在出版社。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'Background: similar amount of hippocampal atrophy has been repeatedly detected in studies comparing FTD to AD patients, nonetheless the distribution of the atrophic changes may be different. Recent techniques such as radial atrophy mapping allow to characterize the atrophic changes of different kinds of dementia based not only on the absolute quantity of atrophy, but also on its spatial distribution. Methods: MRI images from 9 FTD patients and 27 controls were collected at the Radiology Department, University of Verona with a 1.5 Tesla unit (Siemens, Magnetom) and a standard head coil. A gradient-echo 3D-technique was employed for image acquisition with: TR 10 msec; TE 4 msec; TI 300 msec; flip angle 10?; field of view 250 mm; acquisition 2; matrix 160?256. Total acquisition time was 7:40 minutes. MRI images will be normalized by linear (12 parameter) transformation to a customized template using the Statistical Parametric Mapping (SPM99) software. The hippocampi will be manually traced according to a formal protocol with established inter- and intra-rater reliability and 3D parametric surface mesh models will be created to represent the hippocampus in each subject. In order to assess hippocampal morphology, a medial curve will be automatically defined as the 3D curve traced out by the centroid of the hippocampal boundary in each image slice. The radial size of each hippocampus at each boundary point will be assessed by automatically measuring the radial 3D distance from the surface points to the medial curve defined for individual¿s hippocampal surface model. Shorter radial distances will be used as an index of atrophy. Statistical maps will be generated indicating local group differences in radial hippocampal distance. Expected results: the experimental prediction consists in the detection of atrophy in the anteriormost sectors of the hippocampus, as already suggested by a study based on manual tracings (Laakso et al., 2000) or anyway in a different location from that of AD, that involves the CA1 sector and part of the subiculum. Laakso MP, Frisoni GB, Kononen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study. Biol Psychiatry. 2000;47:1056-63. Frisoni GB, Sabattoli F, Lee AD, Dutton RA, Toga AW, Thompson PM. In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. Neuroimage. In press.