CORTICAL DIFFERENCES IN PATIENTS WITH ANTISOCIAL PERSONALITY DISORDER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：很少有神经影像研究集中于反社会人格障碍，但最近的研究表明，内侧前额叶皮质和外侧感觉及周围联合皮质皮质变薄，前额叶皮质和全脑体积减少。 方法：采用磁共振成像、体积测量和皮质模式匹配的方法，对26例男性反社会性人格障碍患者和25例健康男性对照的大脑皮质萎缩解剖模式进行研究。 结果：与健康对照组相比，反社会人格障碍患者表现为双侧前额内侧、眶前叶、扣带回和枕叶的灰质丢失，以及左侧躯体感觉皮质。反社会人格障碍患者的右侧枕叶、左侧扣带回和腹侧眶前叶皮质的缺失在反社会人格障碍患者中表现得更为明显，与健康对照组相比，高精神病患者的右枕叶、左扣带回和腹侧眶前叶皮质的丢失更为明显。 结论：与健康人相比，反社会人格障碍患者在眼眶前额叶、前额内侧、扣带回和枕叶等部位出现皮质丢失。这些区域的结构异常可能与反社会人格障碍的病理生理学有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Few neuroimaging studies have focused on antisocial personality disorder, however recent investigations suggest cortical thinning in the medial prefrontal cortex and lateral sensory and surrounding association cortices, as well as decreased volume in the prefrontal cortex and total brain. Methods: We aimed to identify anatomical patterns of cortical atrophy in 26 antisocial personality disorder males compared to 25 male healthy controls using magnetic resonance imaging volumetry and cortical pattern matching. Results: Antisocial personality disorder individuals as compared to healthy controls showed gray matter loss affecting bilateral medial prefrontal, orbitofrontal, cingulate and occipital, and left somatosensori cortices. Right occipital, left cingulate, and ventral orbitofrontal cortices loss were further pronounced in antisocial personality disorder individuals with high psychopathy respect to healthy controls than antisocial personality disorder individuals with low psychopathy compared to healthy controls. Conclusion: Men with antisocial personality disorder present cortical loss in orbitofrontal, medial prefrontal, cingulate and occipital regions compared to healthy individuals. Structural abnormalities on these regions may be implicated in the pathophysiology of antisocial personality disorder.