HIPPO MORPHOMETRY IN FRONTOTEMPORAL DEMENTIA: A RADIAL ATROPHY MAPPING STUDY

额颞叶痴呆中的河马形态测量：桡骨萎缩图谱研究

• 批准号: 7955665
• 负责人: MARINA BOCCARDI
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955665
• 关键词: Alzheimer' s Disease; Atrophic; Computer Retrieval of Information on Scientific Projects Database; Computer software; Dementia; Detection; Frontotemporal Dementia; Funding; Grant; Head; Hippocampal Formation; Hippocampus (Brain); Image; Individual; Institution; Location; Magnetic Resonance Imaging; Manuals; Maps; Measures; Medial; Methods; Modeling; Morphology; Patients; Protocols documentation; Psychiatry; Radial; Radiology Specialty; Research; Research Personnel; Resources; Slice; Source; Spatial Distribution; Surface; Techniques; Time; United States National Institutes of Health; Universities; base; computational anatomy; entorhinal cortex; hippocampal atrophy; in vivo; indexing; millisecond; morphometry; neuroimaging; neuropathology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'Background: similar amount of hippocampal atrophy has been repeatedly detected in studies comparing FTD to AD patients, nonetheless the distribution of the atrophic changes may be different. Recent techniques such as radial atrophy mapping allow to characterize the atrophic changes of different kinds of dementia based not only on the absolute quantity of atrophy, but also on its spatial distribution. Methods: MRI images from 9 FTD patients and 27 controls were collected at the Radiology Department, University of Verona with a 1.5 Tesla unit (Siemens, Magnetom) and a standard head coil. A gradient-echo 3D-technique was employed for image acquisition with: TR 10 msec; TE 4 msec; TI 300 msec; flip angle 10?; field of view 250 mm; acquisition 2; matrix 160?256. Total acquisition time was 7:40 minutes. MRI images will be normalized by linear (12 parameter) transformation to a customized template using the Statistical Parametric Mapping (SPM99) software. The hippocampi will be manually traced according to a formal protocol with established inter- and intra-rater reliability and 3D parametric surface mesh models will be created to represent the hippocampus in each subject. In order to assess hippocampal morphology, a medial curve will be automatically defined as the 3D curve traced out by the centroid of the hippocampal boundary in each image slice. The radial size of each hippocampus at each boundary point will be assessed by automatically measuring the radial 3D distance from the surface points to the medial curve defined for individual's hippocampal surface model. Shorter radial distances will be used as an index of atrophy. Statistical maps will be generated indicating local group differences in radial hippocampal distance. Expected results: the experimental prediction consists in the detection of atrophy in the anteriormost sectors of the hippocampus, as already suggested by a study based on manual tracings (Laakso et al., 2000) or anyway in a different location from that of AD, that involves the CA1 sector and part of the subiculum. Laakso MP, Frisoni GB, Kononen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study. Biol Psychiatry. 2000;47:1056-63. Frisoni GB, Sabattoli F, Lee AD, Dutton RA, Toga AW, Thompson PM. In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. Neuroimage. 2006; 32(1):104-10.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 ‘背景：在比较FTD与AD患者的研究中，反复检测到海马萎缩程度相似，但萎缩变化的分布可能不同。最近的技术，如放射状萎缩映射允许表征不同类型的痴呆症的萎缩性变化的基础上，不仅萎缩的绝对量，但也对它的空间分布。 研究方法：在维罗纳大学放射科使用1.5 T装置（Siemens，Magnetom）和标准头部线圈采集9例FTD患者和27例对照的MRI图像。采用梯度回波3D技术进行图像采集：TR 10 msec; TE 4 msec; TI 300 msec;翻转角10？;视野250 mm;采集2;矩阵160？256.总采集时间为7：40分钟。 使用统计参数映射（SPM 99）软件，通过线性（12个参数）转换将MRI图像标准化为定制模板。将根据具有已建立的评估者间和评估者内可靠性的正式方案手动追踪海马，并将创建3D参数表面网格模型以代表每例受试者的海马。为了评估海马形态，将中间曲线自动定义为每个图像切片中海马边界质心描绘的3D曲线。通过自动测量从表面点到为个体海马表面模型定义的中间曲线的径向3D距离，评估每个边界点处每个海马的径向尺寸。较短的桡骨距离将被用作萎缩的指标。将生成统计图，指示径向海马距离的局部组差异。 预期成果：实验预测在于检测海马体的最前部分的萎缩，如基于手工描记的研究已经提出的（Laakso等，2000）或无论如何在与AD不同的位置，其涉及CA 1区段和下托的一部分。 Laakso MP，Frisoni GB，Kononen M，Mikkonen M，Beltramello A，Geroldi C，Bianchetti A，Trabucchi M，Soininen H，Aronen HJ. 额颞叶痴呆和阿尔茨海默病的海马和内嗅皮质：形态测量MRI研究。生物精神病学2000;47：1056-63. Frisoni GB，Sabattoli F，Lee AD，达顿RA，Toga AW，Thompson PM. AD患者海马结构的体内神经病理学：一项基于MR的放射状标测研究。神经成像。2006; 32（1）：104-10.