X-RAY STRUCTURES OF COMPONENTS INVOLVED IN MEMBRANE TRANSPORT

参与膜运输的成分的 X 射线结构

• 批准号: 7369529
• 负责人: Tom A Rapoport
• 金额: $ 0.67万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369529
• 关键词: RAY; STRUCTURES; COMPONENTS; INVOLVED; MEMBRANE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to obtain high resolution structures of several important components involved in the transport of proteins or other molecules across membranes. A major goal are Xray structures of the protein-translocating channel bound to its partners, the ribosome or SecA. Another goal is an Xray structure of the CcdA protein, which is responsible for moving reducing equivalents across the bacterial plasma membrane. We are also trying to obtain a high resolution structure of the reticulons, proteins involved in the formation of membrane tubules.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目旨在获得蛋白质或其他分子跨膜运输中涉及的几个重要组分的高分辨率结构。一个主要的目标是X射线结构的蛋白质转运通道结合到它的合作伙伴，核糖体或SecA。另一个目标是CcdA蛋白的X射线结构，它负责将还原当量穿过细菌质膜。我们还试图获得高分辨率的网状结构，这是一种参与膜小管形成的蛋白质。