STRUCTURE OF A BACTERIAL HOMOLOG OF VITAMIN K EPOXIDE REDUCTASE

维生素 K 环氧化物还原酶的细菌同系物的结构

• 批准号: 8361630
• 负责人: Tom A Rapoport
• 金额: $ 0.18万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361630
• 关键词: Anticoagulants; Blood; Blood Coagulation Factor; Disease; Disulfides; Funding; Glutamic Acid; Grant; Homologous Gene; Hydroquinones; Injury; Myocardial Infarction; National Center for Research Resources; Natural regeneration; Principal Investigator; Proteins; Reaction; Research; Research Infrastructure; Resources; Site; Source; Stroke; Structure; United States National Institutes of Health; Vitamin K; Warfarin; carboxylation; cofactor; cost; hydroquinone; oxidation; prevent; structural biology; vitamin K epoxide reductase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Vitamin K epoxide reductase (VKOR) generates vitamin K hydroquinone to sustain gamma-carboxylation of many blood coagulation factors. Coagulation factors require ¿-carboxylation of glutamic acids for activation at sites of injury. The ¿-carboxylase is driven by the oxidation of a vitamin K cofactor; the vitamin K epoxide reductase (VKOR) regenerates this cofactor. A disulfide is formed in VKOR during the latter reaction and is transferred to assist oxidative folding of nascent proteins. VKOR is the target of warfarin, the most commonly prescribed blood thinner used to treat and prevent heart attack, stroke, and other blood related diseases.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 维生素K环氧化物还原酶（VKOR）产生维生素K对苯二酚，以维持许多凝血因子的γ-羧化。凝血因子需要谷氨酸的羧基化作用才能在损伤部位激活。羧化酶由维生素K辅因子的氧化驱动;维生素K环氧化物还原酶（VKOR）再生该辅因子。在后一反应期间，VKOR中形成二硫化物，并被转移以帮助新生蛋白质的氧化折叠。VKOR是华法林的目标，华法林是最常用的血液稀释剂，用于治疗和预防心脏病发作，中风和其他血液相关疾病。