STRUCTURE OF A BACTERIAL HOMOLOG OF VITAMIN K EPOXIDE REDUCTASE

维生素 K 环氧化物还原酶的细菌同系物的结构

• 批准号: 8169247
• 负责人: Tom A Rapoport
• 金额: $ 2.79万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169247
• 关键词: Anticoagulants; Bacteria; Blood Coagulation Factor; Computer Retrieval of Information on Scientific Projects Database; Disulfides; Electron Transport; Enzymes; Epoxy Compounds; Funding; Goals; Grant; Homologous Gene; Hydroquinones; Institution; Light; Oral; Organism; Oxidoreductase; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; Vitamin K; Vitamins; Warfarin; carboxylation; hydroquinone; insight; vitamin K epoxide reductase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vitamin K epoxide reductase (VKOR) generates vitamin K hydroquinone to sustain gamma-carboxylation of many blood coagulation factors. The enzyme is also the target of warfarin, the most commonly used oral anticoagulant. Homologs of VKOR have been discovered in many organisms, including bacteria. In bacteria, VKOR is involved in disulfide bridge formation. The goal of the project is to determine the structure of a bacterial homolog of VKOR. This would allow insight into the mechanism of electron transfer and shed light on the mechanism of warfarin inhibition.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 维生素K环氧化物还原酶（VKOR）产生维生素K对苯二酚，以维持许多凝血因子的γ-羧化。这种酶也是最常用的口服抗凝剂华法林的靶点。VKOR的同源物已在许多生物体中发现，包括细菌。在细菌中，VKOR参与二硫键的形成。该项目的目标是确定VKOR的细菌同系物的结构。这将允许深入了解电子转移的机制，并阐明华法林抑制的机制。