Polylactic Acid Derivatives with Cross-Linkable Groups for Surgical Adhesives

用于手术粘合剂的具有可交联基团的聚乳酸衍生物

• 批准号: 7540381
• 负责人: Cristina Matos-Perez
• 金额: $ 4.1万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7540381
• 关键词: Adhesive cement; Adhesives; Affect; Amines; Amino Acids; Animals; Biocompatible; Biocompatible Materials; Biological; Breathing; Catechols; Dental; Development; Dopa; Drug Delivery Systems; Exhibits; Glass; Goals; Histocompatibility; Iron; Knowledge; Laboratories; Marines; Mechanics; Medicine; Metals; Modeling; Mussels; Oceans; Operative Surgical Procedures; Organism; Oxidants; Peptides; Phase; Polymers; Procedures; Process; Property; Prosthesis; Proteins; Reaction; Sea; Standards of Weights and Measures; Sulfhydryl Compounds; Surface; System; Tissue Engineering; Toxic effect; Variant; Vertebral column; Work; animal extract; base; biocompatible polymer; bone; copolymer; crosslink; design; experience; improved; link protein; poly(lactic acid); scaffold; success

DESCRIPTION (provided by applicant): Current biocompatible polymer systems are being used for controlled drug delivery, scaffolds in tissue engineering and structural supports. These biocompatible polymers provide tissue compatibility, acceptable mechanical properties and low toxicity. Although many of advances have been made in this field, new polymeric systems are very much needed in order to develop new surgical adhesives, nonfouling surfaces and tissue engineering scaffolds. Our laboratory has been designing and synthesizing of new biocompatible polymer systems. We take our inspiration from marine biological adhesives. The adhesive produced by marine mussels is based upon a cross-linked matrix of proteins. We have developed synthetic polymeric mimics of the biological system. The goal of the work proposed here is to design new cross-linking polymers that will be used for surgical adhesives. In order to do so, we will design and synthesize polymers that contain biological cross-linking groups. These cross-linking groups will be placed into standard polymer backbones, thereby generating mimics of marine biological adhesives. We are proposing the use of several cross-linkable groups that mimic amino acids (e.g., catechol) with polylactic acid (PLA) for the backbone. The resulting materials will exhibit improved mechanical and biocompatible properties. Our laboratory will engage in studies to see how the presence of different cross-linkable groups (catechol, thiol, amine) affects the adhesive properties of this copolymer. The utility of these polymers will be enhanced by the tunability from synthetic access to variations in the polymer composition. The synthesis of these new polymers could be essential for development of new surgical adhesives and tissue engineering scaffolds.

描述（由申请人提供）：当前的生物相容性聚合物系统用于受控药物递送、组织工程中的支架和结构支撑。这些生物相容性聚合物提供组织相容性、可接受的机械性能和低毒性。尽管该领域已经取得了许多进展，但仍然非常需要新的聚合物系统来开发新的手术粘合剂、防污表面和组织工程支架。我们的实验室一直在设计和合成新型生物相容性聚合物系统。我们的灵感来自海洋生物粘合剂。贻贝产生的粘合剂基于蛋白质的交联基质。我们开发了生物系统的合成聚合物模拟物。这里提出的工作目标是设计用于手术粘合剂的新型交联聚合物。为此，我们将设计和合成含有生物交联基团的聚合物。这些交联基团将被置于标准聚合物主链中，从而产生海洋生物粘合剂的模拟物。我们建议使用几种模拟氨基酸（例如儿茶酚）的可交联基团，并以聚乳酸（PLA）为骨架。所得材料将表现出改善的机械和生物相容性。我们的实验室将进行研究，看看不同的可交联基团（儿茶酚、硫醇、胺）的存在如何影响该共聚物的粘合性能。这些聚合物的实用性将通过从合成途径到聚合物组合物变化的可调性得到增强。这些新型聚合物的合成对于新型手术粘合剂和组织工程支架的开发至关重要。