Nanocomposites and Electrohydrodynamic Forming: The new route for the development and construction of biocompatible cardiac valves

纳米复合材料和电流体动力学成型：开发和构建生物相容性心脏瓣膜的新途径

• 批准号: EP/D061555/1
• 负责人: Alexander Seifalian
• 金额: $ 25.2万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD061555%2F1
• 关键词: Nanocomposites; Electrohydrodynamic; Forming; new; route

This proposal brings together highly advanced but still exploratory modelling work that has already resulted in a preliminary prototype design. This is a new three scallop tri-symmetric valve whereby the blood flow is extremely high. During the lifetime of the project this finite element analysis will continue to develop improvements in the exact modulus required and leaflet thickness to achieve the highest hydrodynamic performance possible. The nanocomposite designed with silsequioxane in the form of POSS nanocages will be further improved by incorporation of mixtures of different POSS cages in order to result in further improvements in the anti-calcification and /infection properties critical to the clinical success of the project. By usage of EHDA leaflet processing can be achieved that has previously not been possible by conventional techniques such as dip coating in terms of accuracy and quantitative repeatability. By the addition of a dedicated clinical facility with over thirty years experience in implantation of both mechanical and acellular valves into young children a unique engenderment and infra-structure is established critical to the ultimate success of the project. Each centre is a world leader in their respective field and preliminary work has shown that the three groups can work together well. This resulting highly inter-disciplinary tri-partite group allows unique cross-fertilisation of ideas and novel concepts otherwise not achievable. We feel therefore for the modest resources required that the project has a clearly defined chance of success in achieving all of its stated aims. In summary a new prototype working design of heart valve designed with children's needs in mind is the endpoint of this project so that in vivo trials and possibly limited clinical trials can start at the end of the project.

该提案汇集了高度先进但仍处于探索性的建模工作，已经产生了初步的原型设计。这是一个新的三扇贝三对称瓣膜，血流量非常高。在项目的整个生命周期内，有限元分析将继续改进所需的精确模量和叶片厚度，以实现最高的流体动力性能。采用硅氧烷设计的POSS纳米笼形式的纳米复合材料将通过加入不同POSS笼的混合物进一步改进，从而进一步提高抗钙化和/感染性能，这对该项目的临床成功至关重要。通过使用EHDA单张处理可以实现以前传统技术（如浸涂）在准确性和定量可重复性方面不可能实现的功能。通过增加一个专门的临床设施，该设施在为幼儿植入机械瓣膜和脱细胞瓣膜方面拥有超过30年的经验，因此建立了一个独特的生殖和基础设施，这对项目的最终成功至关重要。每个中心在各自的领域都处于世界领先地位，初步工作表明，这三个小组可以很好地合作。由此产生的高度跨学科的三方小组允许独特的思想和新概念的交叉受精，否则是无法实现的。因此，我们认为，对于所需的少量资源，该项目在实现其所有既定目标方面具有明确确定的成功机会。综上所述，一个考虑到儿童需求的新的心脏瓣膜原型工作设计是本项目的终点，以便在项目结束时开始体内试验和可能的有限临床试验。