CSHL Course on Yeast Genetics and Genomics

CSHL 酵母遗传学和基因组学课程

• 批准号: 7458993
• 负责人: DAVID J. STEWART
• 金额: $ 4.89万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7458993
• 关键词: Alleles; Animal Model; Area; Arts; Bacteriology; Bacteriophages; Basic Science; Biochemical; Biochemistry; Biological; Biological Models; Biology; Botany; Cellular biology; Class; Classification; Collaborations; Communities; Complement; Complex; Condition; Daily; Depth; Detection; Development; Educational Curriculum; Educational process of instructing; Educational workshop; Ensure; Evolution; Facility Construction Funding Category; Faculty; Genes; Genetic; Genetic Engineering; Genetic Recombination; Genome; Genomics; Grant; Hand; Immersion Investigative Technique; In Situ; Insertional Mutagenesis; Institutes; Instruction; Knock-out; Laboratories; Learning; Long Island; Mathematics; Methodology; Methods; Molecular; Molecular Biology; Molecular Genetics; Monitor; Mutation; Names; Nature; Numbers; Organelles; Organism; Participant; Philosophy; Physiology; Policies; Postdoctoral Fellow; Principal Investigator; Process; Proteomics; Range; Reagent; Recording of previous events; Recruitment Activity; Regulation; Research; Research Methodology; Research Personnel; Research Training; Resources; Retirement; Role; Rosa; Saccharomyces cerevisiae; Science; Scientist; Screening procedure; Series; Side; Standards of Weights and Measures; Structure; Students; System; Techniques; Technology; Testing; Time; Title; Training; Update; Vertebral column; Visit; Week; Work; Yeasts; Zoology; bacterial genetics; base; biological research; concept; design; desire; experience; functional genomics; gene function; genetic analysis; innovation; instructor; intracellular protein transport; investigator training; knockout gene; lecturer; lectures; loss of function mutation; mathematical model; novel strategies; programs; protein localization location; research study; response; stem; tool; yeast genetics; yeast two hybrid system

DESCRIPTION (provided by applicant): The Cold Spring Harbor Laboratory Yeast Genetics and Genomics Course proposes to continue with a long tradition of serving a critical role in the training of investigators new to the use of S. cerevisiae for biological research. The recent title change reflects a greater emphasis on familiarizing participants with the use of the latest techniques in genomics and proteomics. This three-week highly intensive course is designed to make each student proficient in the fundamentals of yeast genetics which then establishes the conceptual backbone for the more sophisticated methods that are covered as the course progresses. The laboratory experiments are broken into twelve multi-part sections that cover a variety of topics including: 1. Fundamentals of working with yeast; 2. Introduction to yeast molecular biology; 3. Genetic and physical interaction analysis; and 4. Genomics. The experimental portion of the course is complemented by daily theoretical lectures by the instructors chosen for their proven expertise in the system and a world-class seminar series from renowned investigators that utilize the yeast system. As a result every student is exposed to the underlying principles of the methods they are being taught and their state-of-the-art application by the experts in the field. The course has a well-established reputation for, and seeks to continue, serving a diverse community of biologists that include scientists from disparate backgrounds such as evolutionary biology, quantitative biology, as well as biologists working in other systems that can prove a clear benefit from the utilization of yeast, given the large number of resources available for functional genomic studies in this model organism. In addition, educators that seek to incorporate yeast approaches in undergraduate courses are occasional students in the course. Although the general organization of the course is intended to remain the same from year to year, there is a natural evolution in content as the broad field of yeast biology and genomics changes; as instructors are replaced (~1 per year) new expertise is added to the course and the latest technologies and approaches are incorporated into the curriculum by the new instructors. Since at least two instructors remain from year to year, this evolution does not come at the sacrifice of continuity.

描述（由申请人提供）：冷泉港实验室酵母遗传学和基因组学课程建议继续与长期的传统，在培训新的调查人员使用S。用于生物学研究。最近的名称变化反映出更加重视使参与者熟悉基因组学和蛋白质组学最新技术的使用。这个为期三周的高度密集的课程旨在使每个学生精通酵母遗传学的基础知识，然后为课程进展中所涵盖的更复杂的方法建立概念支柱。实验室实验分为十二个多部分的部分，涵盖了各种主题，包括：1。使用酵母的基本原理; 2。酵母分子生物学导论; 3.遗传和物理相互作用分析;和4。基因组学。该课程的实验部分由日常理论讲座补充，这些讲座由在该系统中具有成熟专业知识的讲师和利用酵母系统的着名研究人员举办的世界级研讨会系列组成。因此，每个学生都接触到他们所教授的方法的基本原理以及该领域专家的最先进应用。该课程有一个良好的声誉，并寻求继续，服务于生物学家，其中包括来自不同背景的科学家，如进化生物学，定量生物学，以及在其他系统中工作的生物学家，可以证明一个明确的好处利用酵母，鉴于大量的资源可用于功能基因组研究在这个模式生物。此外，寻求将酵母方法纳入本科课程的教育工作者是该课程的临时学生。虽然课程的总体组织旨在每年保持不变，但随着酵母生物学和基因组学的广泛领域的变化，内容会发生自然演变;随着教师的更换（每年约1名），课程中增加了新的专业知识，新教师将最新的技术和方法纳入课程。由于每年至少有两名教员留下来，这种演变并不以牺牲连续性为代价。