Case-Control Study of Adenoma in Sao Paulo Japanese

圣保罗日本人腺瘤病例对照研究

基本信息

批准号：
7151653
负责人：
LOIC LE MARCHAND
金额：
$ 6.54万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7151653
关键词：
Admixture Age Alcohols Animals Biological Assay Blood specimen Brazil Breast C-Peptide CYP1A1 gene CYP1A2 gene CYP1B1 gene CYP2E1 gene CYP3A4 gene Calcium California Carcinogens Case-Control Studies Caucasians Caucasoid Race Colonoscopy Colorectal Adenoma Colorectal Cancer Companions Consumption Diet Dietary Calcium Dietary Component Dietary Fiber Dyslipidemias Energy Intake Epidemiology Ethnic group Exposure to Fat red 7B stain Fatty acid glycerol esters Fiber Fishes Folate Funding Future Generations Genes Genetic Predisposition to Disease Hawaii Heterocyclic Amines High Density Lipoproteins High temperature of physical object Hip region structure Hormones Hospitals Incidence Insulin Resistance Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Insulin-Like Growth-Factor Binding Protein 1 Intake Investigation Japan Japanese Population Joints Laboratories Life Style Los Angeles MTHFR gene Malignant Neoplasms Meat Metabolic Methods Methylenetetrahydrofolate reductase (NADPH)NAT2 gene Nomads Nutrient Overnutrition Persons Physical activity Plasma Population Predisposition Preparation Process Questionnaires Rate Risk Risk Factors Rural Smoking Somatomedins Somatotropin Stomach Carcinoma Testing Tokyo Variant Vitamin B Complex Vitamin B6 Vitamin D Work adenoma base cancer risk cooking cytochrome P-450 CYP2A6 (human)design folic acid metabolism fruits and vegetables low density lipoprotein triglyceride malignant stomach neoplasm men migration sex

项目摘要

DESCRIPTION (provided by applicant): Smoking, alcohol, overnutrition and a high red meat and low folate, fiber and calcium diet have been associated with colorectal cancer (CRC) and adenoma. Past work, including ours, suggests the importance of the modifying effects of genetic susceptibility factors on most of these associations. Our investigation of the rapid rise in CRC risk among Japanese migrants to Hawaii suggests that Japanese may be more genetically susceptible to the carcinogenic effects of red meat and processed meat, compared to whites, and that they may be particularly protected by a high folate intake. These results are entirely consistent with the sharp rise in CRC incidence observed in Japan over the last 30 years, presumably as a result of the westernization of the diet. However, we have identified another population of Japanese migrants in Sao Paulo, Brazil, for whom CRC rates have remained low, compared to Japanese in Japan an Hawaii, despite a high fat and red meat intake and an affluent western lifestyle. Because this anomaly might provide critical information about protective factors for CRC, we are seeking funding to conduct a colonoscopy-based case- control study of adenoma among Japanese Brazilians in Sao Paulo and to compare findings with our on- going adenoma study (CA 72520) in Hawaii Japanese (565 cases, 660 controls) and with a third (separately funded) companion study (800 cases, 800 controls) conducted in Tokyo. In Sao Paulo, a lifestyle questionnaire will be administered in-person to 550 adenoma cases and 550 endoscopically normal controls matched on age, sex, hospital and date of colonoscopy. In addition to estimating the total intake of energy, nutrients and other dietary components, consumption of meat and fish prepared by high-temperature methods and doneness of meat will be assessed. A blood sample will also be stored for the future testing of exposure markers and genes related to growth hormones, insulin resistance, carcinogen bioactivation and folate metabolism which are being assessed in the Hawaii and Tokyo studies.

描述（由申请人提供）：吸烟，酒精，营养和高红肉和低叶酸，纤维和钙饮食与结直肠癌（CRC）和腺瘤有关。过去的工作，包括我们的工作表明，遗传敏感性因素对大多数关联的修改影响的重要性。我们对日本移民对夏威夷移民的CRC风险迅速增加的调查表明，与白人相比，日本人可能更容易受到红肉和加工肉的致癌作用的影响，并且可能特别受到高叶酸摄入量的保护。这些结果与过去30年中日本观察到的CRC发病率的急剧上升完全一致，大概是由于饮食的西化而导致的。但是，我们已经确定了巴西圣保罗的另一批日本移民，尽管与日本的日本人相比，夏威夷人的CRC率仍然很低，尽管夏威夷人是高脂肪和红肉的摄入量和富裕的西方生活方式。 Because this anomaly might provide critical information about protective factors for CRC, we are seeking funding to conduct a colonoscopy-based case- control study of adenoma among Japanese Brazilians in Sao Paulo and to compare findings with our on- going adenoma study (CA 72520) in Hawaii Japanese (565 cases, 660 controls) and with a third (separately funded) companion study (800 cases, 800 controls) conducted in东京。在圣保罗中，将对550例腺瘤病例和550个内镜下正常对照的生活方式调查表匹配，以年龄，性别，医院和结肠镜检查日期匹配。除了估计能量，营养和其他饮食成分的总摄入量外，还将评估通过高温方法制备的肉类和鱼类的食用以及肉类的含量。还将存储一个血液样本，用于对与生长激素，胰岛素抵抗，致癌生物活化和叶酸代谢相关的暴露标记和基因的未来测试。