Epidemiology and Genetics of Skeletal Muscle Composition

骨骼肌组成的流行病学和遗传学

基本信息

  • 批准号:
    8132812
  • 负责人:
  • 金额:
    $ 13.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-15 至 2013-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Skeletal muscle fat accumulation, independent of overall body fat, may contribute to hyperglycemia and insulin resistance, disorders that are highly prevalent in populations of African origin. A few studies conducted mainly in women or in small samples, also suggest that individuals of African ancestry may have increased skeletal muscle fat compared to Caucasians, independent of overall body fat. However, much remains to be learned about the epidemiology of skeletal muscle composition and its relationship to metabolic disorders, particularly in populations of African ancestry. The goal of the proposed application is to characterize the epidemiology of ectopic skeletal muscle fat. Components of skeletal muscle composition including muscle cross-sectional area, total, subcutaneous, and intermuscular adipose tissue areas, and skeletal muscle density will be measured from existing quantitative computed tomography (pQCT) scans in 2200 men of Caucasian and African descent. The specific aims are to: (1) determine if there are ethnic differences in the distribution of skeletal muscle fat; (2) evaluate if genetic variations in the fatty-acid binding protein 4 gene contribute to skeletal muscle composition in men of African and Caucasian ancestry; and (3) to test the hypothesis that skeletal muscle fat increases with advancing age. The candidate's goals are to: (1) acquire new skills in quantitative computed tomography imaging of skeletal muscle composition; (2) become proficient in high-throughput genotyping and DMA sequence analysis; (3) obtain field experience in conducting longitudinal studies of skeletal muscle composition. PUBLIC HEALTH RELEVANCE: The accomplishment of the proposed aims will greatly enhance our understanding of the epidemiology and genetics of ectopic fat infiltration in skeletal muscle and its relationship to diabetes.
描述(由申请人提供):

项目成果

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IVA MILJKOVIC其他文献

IVA MILJKOVIC的其他文献

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{{ truncateString('IVA MILJKOVIC', 18)}}的其他基金

The Study of Muscle and Physical Performance in African Caribbeans.
非洲加勒比海地区肌肉和身体表现的研究。
  • 批准号:
    10598636
  • 财政年份:
    2022
  • 资助金额:
    $ 13.26万
  • 项目类别:
Myosteatosis, Cognition and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry
非洲血统人群阿尔茨海默病的肌肉脂肪变性、认知和血液生物标志物
  • 批准号:
    10447294
  • 财政年份:
    2022
  • 资助金额:
    $ 13.26万
  • 项目类别:
Epidemiology of Obesity, Diabetes, and Hypertension in African Caribbeans
非洲加勒比地区肥胖、糖尿病和高血压的流行病学
  • 批准号:
    10245074
  • 财政年份:
    2018
  • 资助金额:
    $ 13.26万
  • 项目类别:
Epidemiology of Obesity, Diabetes, and Hypertension in African Caribbeans
非洲加勒比地区肥胖、糖尿病和高血压的流行病学
  • 批准号:
    9752328
  • 财政年份:
    2018
  • 资助金额:
    $ 13.26万
  • 项目类别:
Ectopic adiposity in black men with high type 2 diabetes risk
患有 2 型糖尿病高风险的黑人男性异位肥胖
  • 批准号:
    8418160
  • 财政年份:
    2013
  • 资助金额:
    $ 13.26万
  • 项目类别:
Ectopic adiposity in black men with high type 2 diabetes risk
患有 2 型糖尿病高风险的黑人男性异位肥胖
  • 批准号:
    8892172
  • 财政年份:
    2013
  • 资助金额:
    $ 13.26万
  • 项目类别:
Ectopic adiposity in black men with high type 2 diabetes risk
患有 2 型糖尿病高风险的黑人男性异位肥胖
  • 批准号:
    8735936
  • 财政年份:
    2013
  • 资助金额:
    $ 13.26万
  • 项目类别:
Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black Men
黑人男性 2 型糖尿病与肝脏和肌肉肥胖的关系
  • 批准号:
    8165517
  • 财政年份:
    2011
  • 资助金额:
    $ 13.26万
  • 项目类别:
Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black Men
黑人男性 2 型糖尿病与肝脏和肌肉肥胖的关系
  • 批准号:
    8328607
  • 财政年份:
    2011
  • 资助金额:
    $ 13.26万
  • 项目类别:
Epidemiology and Genetics of Skeletal Muscle Composition
骨骼肌组成的流行病学和遗传学
  • 批准号:
    7571202
  • 财政年份:
    2008
  • 资助金额:
    $ 13.26万
  • 项目类别:

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非裔美国人冠心病和相关代谢组标记物的混合图谱
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非裔美国儿童急性淋巴细胞白血病的混合分析:ADMIRAL 研究
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  • 财政年份:
    2020
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    10626271
  • 财政年份:
    2020
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非裔美国人缺血性中风的混合图谱
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  • 财政年份:
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