Radiation Oncology 2008 Gordon Research Conference

描述(申请人提供)：会议的目标是增加我们对电离辐射对细胞影响的了解，从而可以开发出改进的治疗策略，以增加对肿瘤细胞的杀伤力，并减少对正常细胞的影响。在过去的15年里，对DNA损伤的反应的生物学基础已经变得越来越清楚。然而，相对较少的研究集中在肿瘤细胞和正常细胞的差异上，在正常细胞和肿瘤细胞的差异上，显然有机会利用特定的肿瘤细胞在DNA损伤反应中的缺陷来优化电离辐射的治疗效果。已知的肿瘤DNA损伤反应的差异涉及染色质组织、细胞周期检查点反应、检查点适应、停滞复制叉的管理、同源重组修复及其在双链断裂修复中的相对作用、低氧对DNA修复的影响以及表观遗传调节机制。这些主题构成了最新的放射肿瘤学前沿GRC会议的基础。这次会议的独特之处在于聚焦于DNA损伤反应中与肿瘤相关的差异，以及这些基础科学观察对放射疗法治疗人类癌症的影响。作为科学报告的结果，每一位讨论领导人都将得到明确的指示，说明如何制定新的翻译倡议。被邀请的演讲者将被鼓励在他们的演讲中开发一段讨论潜在的治疗应用的部分。这次研究会议的结果应该会改进目前提高放射肿瘤学治疗率的新策略。放射疗法用于治疗50%的人类癌症，提高其疗效将对目前的治疗方法产生重大影响。

DESCRIPTION (provided by applicant): The conference goal is to increase our understanding of the effects of ionizing radiation on cells, such that improved therapeutic strategies can be developed to increase tumor cell killing and to reduce the effects on normal cells. The biological basis of the response to DNA damage has become increasingly well understood in the last 15 years. However, relatively little research has focused on tumor cell versus normal cell differences, where there is a clear opportunity to capitalize on specific tumor cell deficiencies in the DNA damage response to optimize the therapeutic effects of ionizing radiation. Known differences in the DNA damage response in tumors have been found in relation to chromatin organization, cell cycle checkpoint responses, checkpoint adaptation, management of the stalled replication fork, repair by homologous recombination and its relative role in double-strand break repair, the effect of hypoxia on DNA repair and epigenetic regulatory mechanisms. These topics form the basis of this latest cutting-edge GRC conference in Radiation Oncology. The unique feature of this conference is the focus on tumor related differences in the DNA damage response and the implications of these basic science observations in the treatment of human cancer by radiation therapy. Each discussion leader will be given clear instructions on developing new translational initiatives as a result of the scientific presentations. The invited speakers will be encouraged to develop a section of their talk in discussing potential therapeutic applications. The consequence of this research conference should improve current novel strategies for improving the therapeutic ratio in radiation oncology. Improving the effectiveness of radiation therapy, which is used in the treatment of 50% of all human cancers, will have a major impact on current approaches to treatment.