Radiation Oncology 2008 Gordon Research Conference
放射肿瘤学 2008 年戈登研究会议
基本信息
- 批准号:7391039
- 负责人:
- 金额:$ 0.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-01-27 至 2009-01-26
- 项目状态:已结题
- 来源:
- 关键词:Basic ScienceBiologicalCell Cycle CheckpointCellsChromatinDNA DamageDNA RepairDouble Strand Break RepairEffectivenessEpigenetic ProcessGoalsHumanHypoxiaInstructionIonizing radiationMalignant NeoplasmsNormal CellRadiation OncologyRadiation therapyRelative (related person)ResearchRoleTherapeuticTherapeutic Effectbasecancer radiation therapycell killinghomologous recombinationimprovedneoplastic cellnovel strategiesrepairedresponsesymposiumtumor
项目摘要
DESCRIPTION (provided by applicant): The conference goal is to increase our understanding of the effects of ionizing radiation on cells, such that improved therapeutic strategies can be developed to increase tumor cell killing and to reduce the effects on normal cells. The biological basis of the response to DNA damage has become increasingly well understood in the last 15 years. However, relatively little research has focused on tumor cell versus normal cell differences, where there is a clear opportunity to capitalize on specific tumor cell deficiencies in the DNA damage response to optimize the therapeutic effects of ionizing radiation. Known differences in the DNA damage response in tumors have been found in relation to chromatin organization, cell cycle checkpoint responses, checkpoint adaptation, management of the stalled replication fork, repair by homologous recombination and its relative role in double-strand break repair, the effect of hypoxia on DNA repair and epigenetic regulatory mechanisms. These topics form the basis of this latest cutting-edge GRC conference in Radiation Oncology. The unique feature of this conference is the focus on tumor related differences in the DNA damage response and the implications of these basic science observations in the treatment of human cancer by radiation therapy. Each discussion leader will be given clear instructions on developing new translational initiatives as a result of the scientific presentations. The invited speakers will be encouraged to develop a section of their talk in discussing potential therapeutic applications. The consequence of this research conference should improve current novel strategies for improving the therapeutic ratio in radiation oncology. Improving the effectiveness of radiation therapy, which is used in the treatment of 50% of all human cancers, will have a major impact on current approaches to treatment.
描述(由申请人提供):会议的目标是增加我们对电离辐射对细胞影响的理解,从而可以开发改进的治疗策略,以增加肿瘤细胞杀伤并减少对正常细胞的影响。 在过去的15年里,对DNA损伤反应的生物学基础已经变得越来越好理解。 然而,相对较少的研究集中在肿瘤细胞与正常细胞的差异,其中有一个明确的机会,利用特定的肿瘤细胞缺陷的DNA损伤反应,以优化电离辐射的治疗效果。 肿瘤中DNA损伤反应的已知差异与染色质组织、细胞周期检查点反应、检查点适应、停滞复制叉的管理、同源重组修复及其在双链断裂修复中的相对作用、缺氧对DNA修复的影响和表观遗传调控机制有关。 这些主题构成了放射肿瘤学最新前沿GRC会议的基础。 本次会议的独特之处在于重点关注DNA损伤反应中与肿瘤相关的差异,以及这些基础科学观察对放射治疗人类癌症的影响。 每位讨论负责人都将得到明确的指示,说明如何根据科学报告制定新的翻译倡议。 将鼓励受邀演讲者在讨论潜在的治疗应用时开发他们的演讲部分。 这次研究会议的结果应该改善目前的新策略,提高放射肿瘤学的治疗率。 提高放射治疗的有效性,用于治疗50%的人类癌症,将对目前的治疗方法产生重大影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Simon N. Powell其他文献
The predicted effect of HDR dose heterogeneity on local/regional control for post-surgical patients: Location matters
- DOI:
10.1016/j.brachy.2006.03.090 - 发表时间:
2006-04-01 - 期刊:
- 影响因子:
- 作者:
Joseph O. Deasy;Simon N. Powell;Imran Zoberi - 通讯作者:
Imran Zoberi
A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells
人类细胞中的位点特异性复制叉阻断激活局部 ATR 依赖性检查点通路
- DOI:
10.1101/2023.03.26.534293 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Sana Ahmed;Manisha Jalan;Helen E. Grimsley;Aman Sharma;Shyam Twayana;Settapong T. Kosiyatrakul;Christopher Thompson;C. Schildkraut;Simon N. Powell - 通讯作者:
Simon N. Powell
Defining the Optimal Dose for 3-Dimensional Conformal Accelerated Partial Breast Irradiation: 15-Year Follow-Up of a Dose-Escalation Trial
定义三维适形加速部分乳腺照射的最佳剂量:一项剂量递增试验的 15 年随访
- DOI:
10.1016/j.ijrobp.2024.10.029 - 发表时间:
2025-03-15 - 期刊:
- 影响因子:6.500
- 作者:
Alphonse G. Taghian;George E. Naoum;Lior Z. Braunstein;Andrzej Niemierko;Barbara L. Smith;Michele A. Gadd;Simon N. Powell;Abram Recht - 通讯作者:
Abram Recht
The biology of radioresistance: similarities, differences and interactions with drug resistance
- DOI:
10.1007/bf00744671 - 发表时间:
1993-01-01 - 期刊:
- 影响因子:1.700
- 作者:
Simon N. Powell;Edward H. Abraham - 通讯作者:
Edward H. Abraham
Ultrasound-mediated mechanical forces selectively kill tumor cells
超声介导的机械力选择性杀死肿瘤细胞
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
A. Tijore;F. Margadant;Mingxi Yao;Anushya Hariharan;C. Chew;Simon N. Powell;G. Bonney;M. Sheetz - 通讯作者:
M. Sheetz
Simon N. Powell的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Simon N. Powell', 18)}}的其他基金
MSK SPORE in Genomic Instability in Breast Cancer
MSK SPORE 在乳腺癌基因组不稳定性中的作用
- 批准号:
10237877 - 财政年份:2020
- 资助金额:
$ 0.6万 - 项目类别:
MSK SPORE in Genomic Instability in Breast Cancer
MSK SPORE 在乳腺癌基因组不稳定性中的作用
- 批准号:
10704063 - 财政年份:2020
- 资助金额:
$ 0.6万 - 项目类别:
Defining and Targeting Homologous Recombination Deficiency in Breast Cancer
乳腺癌同源重组缺陷的定义和针对
- 批准号:
10478008 - 财政年份:2020
- 资助金额:
$ 0.6万 - 项目类别:
Defining and Targeting Homologous Recombination Deficiency in Breast Cancer
乳腺癌同源重组缺陷的定义和针对
- 批准号:
10237881 - 财政年份:2020
- 资助金额:
$ 0.6万 - 项目类别:
MSK SPORE in Genomic Instability in Breast Cancer
MSK SPORE 在乳腺癌基因组不稳定性中的作用
- 批准号:
10477981 - 财政年份:2020
- 资助金额:
$ 0.6万 - 项目类别:
Defining and Targeting Homologous Recombination Deficiency in Breast Cancer
乳腺癌同源重组缺陷的定义和针对
- 批准号:
10704096 - 财政年份:2020
- 资助金额:
$ 0.6万 - 项目类别:
相似海外基金
NSF/BIO-DFG: Biological Fe-S intermediates in the synthesis of nitrogenase metalloclusters
NSF/BIO-DFG:固氮酶金属簇合成中的生物 Fe-S 中间体
- 批准号:
2335999 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
Collaborative Research: Conference: Large Language Models for Biological Discoveries (LLMs4Bio)
合作研究:会议:生物发现的大型语言模型 (LLMs4Bio)
- 批准号:
2411529 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
Collaborative Research: Conference: Large Language Models for Biological Discoveries (LLMs4Bio)
合作研究:会议:生物发现的大型语言模型 (LLMs4Bio)
- 批准号:
2411530 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
Collaborative Research: NSF-ANR MCB/PHY: Probing Heterogeneity of Biological Systems by Force Spectroscopy
合作研究:NSF-ANR MCB/PHY:通过力谱探测生物系统的异质性
- 批准号:
2412551 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
Elucidating mechanisms of biological hydrogen conversion through model metalloenzymes
通过模型金属酶阐明生物氢转化机制
- 批准号:
2419343 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
Collaborative Research: The Interplay of Water Condensation and Fungal Growth on Biological Surfaces
合作研究:水凝结与生物表面真菌生长的相互作用
- 批准号:
2401507 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
DESIGN: Driving Culture Change in a Federation of Biological Societies via Cohort-Based Early-Career Leaders
设计:通过基于队列的早期职业领袖推动生物协会联盟的文化变革
- 批准号:
2334679 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
REU Site: Modeling the Dynamics of Biological Systems
REU 网站:生物系统动力学建模
- 批准号:
2243955 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Standard Grant
Defining the biological boundaries to sustain extant life on Mars
定义维持火星现存生命的生物边界
- 批准号:
DP240102658 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Discovery Projects
Advanced Multiscale Biological Imaging using European Infrastructures
利用欧洲基础设施进行先进的多尺度生物成像
- 批准号:
EP/Y036654/1 - 财政年份:2024
- 资助金额:
$ 0.6万 - 项目类别:
Research Grant