Prolactin and Growth Hormone Family 2008 Gordon Research Conference

催乳素和生长激素家族 2008 年戈登研究会议

• 批准号: 7474529
• 负责人: HALLGEIR RUI
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7474529
• 关键词: Affect; Age; Area; Behavior; Biochemical; Biological; Biology; Depth; Development; Family; Growth; Hormones; Immune system; International; Ligands; Longevity; Maintenance; Mediating; Osteogenesis; PRL gene; Pathway interactions; Peptides; Physiological; Prolactin; Prolactin Receptor; Reproduction; Research; Research Personnel; Signal Transduction; Somatotropin; Staging; System; angiogenesis; carcinogenesis; career; insight; interest; neurogenesis; receptor; repaired; symposium; tumorigenesis

DESCRIPTION (provided by applicant): The 2008 Prolactin and Growth Hormone Gordon Research Conference will provide a forum for the presentation and active discussion of the most cutting-edge information and ideas on Prolactin, Growth Hormone and related peptides. The Gordon Research Conference format will bring together investigators that are international leaders in the structural, biochemical, cell signaling, physiological, developmental and clinicalpathological aspects of these hormone ligands and their receptors. We expect that this conference will provide a thorough and in-depth coverage of prolactin and growth hormone biology, thus continuing the tradition of this being the premier meeting in this field. The peptide ligands and receptors for PRL and GH have been shown to mediate critical biological actions related to reproduction and growth, respectively. However, PRL has now been documented to also affect many nonreproductive targets, such as modulating behavior, promoting neurogenesis, inducing tumorigenesis, regulating angiogenesis and bone formation, and impacting the immune system. Similarly, GH biology extends beyond its classical IGF-1-stimulatory and growth-promoting effects. Indeed, the GH/IGF-1 system has been implicated in carcinogenesis, cellular maintenance and repair, and longevity/aging pathways. While these recent advances have provided important insights into PRL and GH actions, nevertheless the precise mechanisms by which these two hormones mediate their effects remain unanswered. We encourage investigators at all career stages interested in these areas to attend the PRL and Growth Hormone GRC.

描述（由申请人提供）： 2008 年催乳素和生长激素戈登研究会议将提供一个论坛，用于展示和积极讨论有关催乳素、生长激素和相关肽的最前沿信息和想法。戈登研究会议的形式将汇集这些激素配体及其受体的结构、生化、细胞信号传导、生理、发育和临床病理学方面的国际领先研究人员。我们期望本次会议将对催乳素和生长激素生物学进行全面、深入的报道，从而延续本次会议作为该领域顶级会议的传统。 PRL 和 GH 的肽配体和受体已被证明分别介导与繁殖和生长相关的关键生物作用。然而，现已证明 PRL 也影响许多非生殖目标，例如调节行为、促进神经发生、诱导肿瘤发生、调节血管生成和骨形成以及影响免疫系统。同样，GH 的生物学作用超出了其经典的 IGF-1 刺激和生长促进作用。事实上，GH/IGF-1 系统与致癌、细胞维护和修复以及长寿/衰老途径有关。虽然这些最新进展为 PRL 和 GH 作用提供了重要见解，但这两种激素介导其作用的精确机制仍然没有得到解答。我们鼓励对这些领域感兴趣的各个职业阶段的研究人员参加 PRL 和生长激素 GRC。