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Pregnancy-Related Sleep Disturbances May Increase Pregnancy Complications

与怀孕相关的睡眠障碍可能会增加怀孕并发症

基本信息

批准号：
7489951
负责人：
MICHELE L OKUN
金额：
$ 8.86万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2009-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The goal of this research plan is to examine how pregnancy-related sleep disturbances may increase the incidence of pregnancy complications. There is a growing interest in the role of inflammation in the pathogenesis of pregnancy complications, and it is possible that sleep may play an important role in the relationship between inflammatory processes and pregnancy complications. Women often endorse disruption of sleep during pregnancy with frequent complaints of poor sleep quality, increased nocturnal awakenings and long periods of wakefulness. There is a mounting literature demonstrating an association between disturbed sleep (poor quality, poor continuity or short sleep duration) and increases in circulating and secreted levels of proinflammatory cytokines in nonpregnant populations. Preliminary work conducted during my graduate career provides initial evidence that pregnancy-related sleep disturbances are associated with similar alterations in proinflammatory cytokines. These same proinflammatory cytokines, shown to be altered with sleep disruption, are similarly associated with pregnancy complications such as spontaneous abortion, preeclampsia, gestational diabetes, and preterm labor and birth. Aim 1. Examine the role of sleep in pregnancy complications. Hypothesis 1: Disturbed sleep will be associated with increased incidence of pregnancy complications including spontaneous abortion, preeclampsia, gestational diabetes, and preterm labor and birth. Aim 2. Examine the temporal relationship between sleep and proinflammatory cytokines during pregnancy. Hypothesis 2: Disturbed sleep will be associated with subsequent increases in proinflammatory cytokines.Aim 3. Examine the role of sleep related increases in proinflammatory cytokines in pregnancy complications. Hypothesis 3: Sleep related increases in proinflammatory cytokines will be associated with increased incidence of pregnancy complications including spontaneous abortion, preeclampsia, gestational diabetes, and preterm labor and birth. A total of 120 pregnant women will be studied across pregnancy. Each woman will participate in a 15-day assessment once per trimester. These assessments will include sleep data attained by actigraphy, sleep diary and sleep questionnaires; cytokine data ascertained from plasma and stimulation assays; health behaviors assessed by self-report; and data on pregnancy complications provided by medical records.

描述（由申请人提供）：本研究计划的目标是研究妊娠相关睡眠障碍如何增加妊娠并发症的发生率。人们对炎症在妊娠并发症发病机制中的作用越来越感兴趣，睡眠可能在炎症过程和妊娠并发症之间的关系中发挥重要作用。妇女经常赞同怀孕期间睡眠中断，经常抱怨睡眠质量差，夜间觉醒增加和长时间清醒。有越来越多的文献表明，睡眠障碍（质量差，连续性差或睡眠时间短）与非妊娠人群中促炎细胞因子的循环和分泌水平增加之间存在相关性。在我的研究生生涯中进行的初步工作提供了初步证据，表明妊娠相关的睡眠障碍与促炎细胞因子的类似改变有关。这些相同的促炎细胞因子，显示出随着睡眠中断而改变，与妊娠并发症如自然流产、先兆子痫、妊娠糖尿病、早产和分娩类似地相关。目标1.检查睡眠在妊娠并发症中的作用。假设1：睡眠障碍与妊娠并发症的发生率增加有关，包括自然流产、先兆子痫、妊娠期糖尿病、早产和分娩。目标2.检查怀孕期间睡眠和促炎细胞因子之间的时间关系。假设2：睡眠紊乱与随后促炎细胞因子的增加有关。检查睡眠相关的促炎细胞因子增加在妊娠并发症中的作用。假设三：睡眠相关的促炎细胞因子增加与妊娠并发症的发生率增加有关，包括自然流产、先兆子痫、妊娠期糖尿病和早产。将在整个妊娠期间对共计120名孕妇进行研究。每名妇女将参加为期15天的评估，每三个月一次。这些评估将包括通过活动记录仪、睡眠日记和睡眠问卷获得的睡眠数据;从血浆和刺激测定中确定的细胞因子数据;通过自我报告评估的健康行为;以及通过医疗记录提供的妊娠并发症数据。