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Maternal physiological factors influencing labor length

影响产程长度的产妇生理因素

基本信息

批准号：
7339023
负责人：
JEREMY L NEAL
金额：
$ 3.23万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-03 至 2009-01-02
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7339023
关键词：
Accounting Acids Admission activity American College of Obstetricians and Gynecologists Birth Bladder Blood Glucose Carrying Capacities Centers for Disease Control and Prevention (U.S.)Cesarean section Condition Contracts Diagnosis Dystocia Event Fatigue Feedback Fetus Frequencies Goals Health Healthy People 2010 Hemoglobin Hemorrhage Hour Hydration status Infection Injury Intestines Isoenzymes Ketone Bodies Lactate Dehydrogenase Lactate Dehydrogenases Lead Length Measures Morbidity - disease rate Mothers Muscle Fatigue Myometrial National Research Service Awards Neonatal Newborn Respiratory Distress Syndrome Nutrient Operative Surgical Procedures Outcome Oxygen Perfusion Physiological Population Pregnancy Production Rate Reporting Research Priority Risk Sampling Serum Specific Gravity Surgical complication Time Urine Uterus Vaginal delivery procedure Week Woman Work World Health Organization cell injury improved lactate dehydrogenase 5 maternal serum mortality myometrium neonate persistent pulmonary hypertension trend

项目摘要

The World Health Organization advises that no region in the world is justified in having a C-section rate >10- 15%. In 2004, the U.S. had a total rate of 29.1% and a primary rate of 20.6%. As these rates rise, so does the morbidity and mortality risk imposed on mothers and neonates. Dystocia is the greatest contributor to C- sections accounting for nearly 50% of all C-sections performed on nulliparous women. It is known that [1] abnormalities of uterine power are, by far, the greatest contributor to dystocia and [2] dystocia-afflicted labors that progress to a vaginal delivery have a much greater likelihood of increased labor lengths. This suggests uterine fatigue may be involved. This study will investigate factors that may: [1] contribute to increased labor length by increasing uterine fatigue; [2] indicate energy availability is inadequate; [3] indicate myometrial cell- damage has occurred. Specific aims will identify the relationships between labor length and maternal: [1] oxygen carrying capacity; [2] hydration status; [3] nutritive substrate status and; [4] myometrial cell-damage. A convenience sample of low-risk, nulliparous women in labor (n = 73) at term (> 37 - < 42 wks) will be studied. Identifying events / conditions that contribute to increased labor length via effects on uterine fatigue may unveil factors contributing to labor dystocia. Results may offer support to alternative labor management strategies.

世界卫生组织建议，世界上没有一个地区的剖腹产率超过10- 百分之十五2004年，美国的总比率为29.1%，初级比率为20.6%。随着这些利率的上升，对母亲和新生儿造成的发病率和死亡率风险。难产是C- 占所有未经产妇女剖腹产的近50%。据了解，[1] 到目前为止，宫缩力异常是难产和[2]难产折磨分娩的最大原因阴道分娩的进展有更大的可能性增加产程长度。这表明可能涉及子宫疲劳。这项研究将调查可能的因素：[1]有助于增加劳动力 [2]这是一个很好的解释，因为它是一个很好的解释，因为它是一个很好的解释，因为它是一个很好的解释。发生了损害。具体目标将确定分娩时间和产妇之间的关系：[1] 携氧能力; [2]水合状态; [3]营养基质状态和; [4]子宫肌层细胞损伤。一将对足月（> 37 - < 42周）的低风险、未经产分娩妇女（n = 73）的便利样本进行研究。通过对子宫疲劳的影响，确定有助于延长分娩时间的事件/状况，导致难产的因素。研究结果可为替代劳动力管理策略提供支持。