Maternal physiological factors influencing labor length

影响产程长度的产妇生理因素

• 批准号: 7156819
• 负责人: JEREMY L NEAL
• 金额: $ 3.36万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2009-01-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156819
• 关键词: birth; clinical research; fatigue; sectioning

DESCRIPTION (provided by applicant): The World Health Organization advises that no region in the world is justified in having a C-section rate >10- 15%. In 2004, the U.S. had a total rate of 29.1% and a primary rate of 20.6%. As these rates rise, so does the morbidity and mortality risk imposed on mothers and neonates. Dystocia is the greatest contributor to C- sections accounting for nearly 50% of all C-sections performed on nulliparous women. It is known that [1] abnormalities of uterine power are, by far, the greatest contributor to dystocia and [2] dystocia-afflicted labors that progress to a vaginal delivery have a much greater likelihood of increased labor lengths. This suggests uterine fatigue may be involved. This study will investigate factors that may: [1] contribute to increased labor length by increasing uterine fatigue; [2] indicate energy availability is inadequate; [3] indicate myometrial cell- damage has occurred. Specific aims will identify the relationships between labor length and maternal: [1] oxygen carrying capacity; [2] hydration status; [3] nutritive substrate status and; [4] myometrial cell-damage. A convenience sample of low-risk, nulliparous women in labor (n = 73) at term (greater than or equal to 37 - less than or equal to 42 wks) will be studied. Identifying events/conditions that contribute to increased labor length via effects on uterine fatigue may unveil factors contributing to labor dystocia. Results may offer support to alternative labor management strategies.

描述(由申请人提供)：世界卫生组织建议，世界上没有一个地区有理由实行10-15%的剖腹产率。2004年，美国的总利率为29.1%，基本利率为20.6%。随着这些比率的上升，母亲和新生儿面临的发病率和死亡风险也在上升。难产是剖腹产的最大原因，占所有未分娩妇女剖腹产的近50%。众所周知，到目前为止，子宫力量的异常是难产的最大因素，而难产的难产进展为阴道分娩的产妇更有可能增加产程。这表明子宫疲劳可能与此有关。这项研究将调查可能的因素：[1]通过增加子宫疲劳而导致产程延长；[2]表明能量供应不足；[3]表明子宫肌层细胞损伤已经发生。具体目标将确定产程和母体之间的关系：[1]携氧能力；[2]水合状态；[3)营养底物状态；[4]子宫肌层细胞损伤。将对临产时(大于或等于37周-小于或等于42周)的低风险未分娩妇女(n=73)进行方便抽样研究。确定通过对子宫疲劳的影响而导致产程延长的事件/条件，可能会揭示导致难产的因素。研究结果可能会为其他劳动力管理策略提供支持。