Cell-Cell Interactions in Developing Retina

视网膜发育中的细胞间相互作用

• 批准号: 7469521
• 负责人: Nicholas E Baker
• 金额: $ 49.63万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7469521
• 关键词: Accounting; Address; Affect; Animals; Anterior; Cell Communication; Cell Cycle; Cell Cycle Arrest; Cell Proliferation; Cell Survival; Cells; Classification; Development; Drosophila eye; Drosophila genus; Epidermal Growth Factor Receptor; Epithelium; Future; Gene Targeting; Genes; Genetic; Genetic Transcription; Genotype; Goals; Growth; Growth Factor; Mediating; Mutation; Organ; Pathway interactions; Pattern; Photoreceptors; Process; Receptor Signaling; Regulation; Retina; Retinal; Role; Role playing therapy; Signal Pathway; Signal Transduction; Staging; TNF gene; Time; Undifferentiated; extracellular; genetic strain; mutant; neurogenesis; notch protein; prevent; response; transcription factor

DESCRIPTION (provided by applicant): In multicellular animals, growth, proliferation and differentiation are regulated by extracellular signals. Genetic studies of the Drosophila eye have identified signals that drive a wave of differentiation across the retinal epithelium, and regulate cell proliferation and survival processes that are closely associated with differentiating photoreceptor cells. Most extracellular signaling pathways do not act independently but often interact antagonistically, synergistically or redundantly. Future studies will determine what extracellular signals control the patterning of the retina prior to differentiation by taking a systematic approach to eliminate the response to Hh, Dpp, Wg, N and EGF receptor pathways. Genetic mosaic analysis of mutant genes affecting each pathway will be compared with genotypes where one or more signaling pathways function. Extracellular signals arrest the cell cycle prior to the onset of neurogenesis, and the function of this arrest will be assessed through study of the mutant genotypes that prevent it. The mechanisms of selected gene targets of extracellular signals in proliferation, differentiation, and survival will be elucidated. These studies will take a systematic approach to the regulation of the retina by extracellular signals.

描述（由申请人提供）：在多细胞动物中，细胞外信号调节生长、增殖和分化。果蝇眼睛的遗传研究已经确定了驱动视网膜上皮分化波的信号，并调节与感光细胞分化密切相关的细胞增殖和存活过程。大多数细胞外信号通路不是独立作用的，而是经常以拮抗、协同或冗余的方式相互作用。未来的研究将通过采取系统的方法来消除对Hh，Dpp，Wg，N和EGF受体途径的反应，来确定哪些细胞外信号在分化前控制视网膜的图案化。影响每个途径的突变基因的遗传镶嵌分析将与其中一个或多个信号传导途径起作用的基因型进行比较。细胞外信号在神经发生开始之前阻滞细胞周期，这种阻滞的功能将通过研究阻止它的突变基因型来评估。细胞外信号在增殖、分化和存活中的选定基因靶点的机制将得到阐明。这些研究将采取系统的方法来研究细胞外信号对视网膜的调节。