Hormone-dependent autophagy and growth signalling in developmental cell death

细胞死亡对细胞和组织的动态平衡是必不可少的，其失调与许多疾病有关。我们发现了一种新的细胞死亡模式，这种模式涉及自噬。我们现在已经确定了转化生长因子-？信号通路参与了自噬依赖的细胞死亡，在许多人类病理过程中起着重要作用。我们建议的研究将进一步表征这一重要的信号轴，并研究其在发育、正常生理和疾病中的意义。

Cell death is essential for cell and tissue homeostasis and its dysregulation is associated with many diseases. We discovered a new mode of cell death that involves autophagy. We have now identified that TGF-? signalling pathway, which has roles in numerous human pathologies, is involved in autophagy-dependent cell death. Our proposed studies will further characterise this important signalling axis and study its significance in development, normal physiology and disease.