Resorbable Calcium Phosphate Ceramics for Bone Graft.

用于骨移植的可吸收磷酸钙陶瓷。

• 批准号: 7694825
• 负责人: SUSMITA BOSE
• 金额: $ 3.38万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7694825
• 关键词: Autologous Transplantation; Behavior; Biodegradation; Biological; Bone Growth; Bone Regeneration; Bone Substitutes; Bone Tissue; Bone Transplantation; Bone remodeling; Cells; Ceramics; Cereals; Characteristics; Chemicals; Chemistry; Clinical; Data; Defect; Development; Elements; Face; Goals; Harvest; Healed; Human; Implant; In Vitro; Kinetics; Knowledge; Lead; Length; Magnesium; Malignant Bone Neoplasm; Mechanics; Modeling; Operative Surgical Procedures; Oryctolagus cuniculus; Osteoblasts; Osteoclasts; Osteoporosis; Oxides; Physiologic calcification; Porosity; Process; Property; Public Health Applications Research; Range; Rate; Rattus; Research; Research Project Grants; Sampling; Series; Silicon; Site; Spinal; Spinal Fusion; Strontium; Structure; Testing; Time; Tissue Engineering; Trace Elements; Transplanted tissue; Zinc; base; biomaterial compatibility; bone; bone cell; bone healing; calcium phosphate; cell growth; craniomaxillofacial; design; desire; healing; in vivo; nanoparticle; nanopowder; nanoscale; novel; physical property; reconstruction; repaired; scaffold; size; success

DESCRIPTION (provided by applicant): Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. There is a need for the development of biodegradable ceramic materials with controlled degradation kinetics that will act as a scaffold and support bone remodeling. Our long range goal is to elucidate strength loss mechanism in CaP based material and scaffold to develop bone graft for specific application. Fundamental information on controlled degradation behavior of CaP based materials to identify optimal material composition can help us design and tailor resorbable tissue engineered bone replacement based on application needs. The objective of this research is to test our central hypothesis, which is chemistry and microstructure in CaP based ceramics can modify strength loss in these materials. Our preliminary data indicate that a minimum amount of trace elements (dopants) can have significant effects on physical and mechanical properties of CaPs. Cell-materials interactions can also be influenced by the presence of trace elements. The specific aims are 1) To investigate effects of nanoscale CaP with three different Ca to P ratios, 1.25:1, 1.33:1 and 1.5:1, through synthesis, processing, characterization and in vitro and in vivo bone cell-materials interactions. 2) To determine the effects of four dopants, Zinc, Magnesium, Silicon, and Strontium oxides in single and multi-element composition, along with three CaP ceramics with Ca:P = 1.25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity and verify the influence of porosity on their properties and study in vitro and in vivo interactions. In order to accomplish these aims, we will conduct a series of studies including synthesis of nanoscale CaPs with single and multi element dopants, characterize their chemical, physical and mechanical properties, and in vitro and in vivo strength loss behavior in rat and rabbit models. It is envisioned that results from the proposed study will lead to the development of CaPs with tailored degradation kinetics that can be used in spinal fusion, maxillo- and cranio-facial implants and small scale bone defect applications. PUBLIC HEALTH RELEVANCE Resorbable Calcium Phosphate Ceramics for Bone Graft Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. The objective of this research is to test our central hypothesis, which is chemistry and microstructure in Calcium phosphate (CaP) based ceramics can modify strength loss in these materials. It is envisioned that results from the proposed study will lead to the development of CaPs with tailored degradation kinetics that can be used in spinal fusion, maxillo- and cranio-facial implants and small scale bone defect applications.

描述（由申请人提供）：磷酸钙（CaP）基陶瓷因其优异的生物相容性而用于硬组织工程。需要开发具有受控降解动力学的可生物降解的陶瓷材料，其将充当支架并支持骨重建。我们的长期目标是阐明CaP基材料和支架的强度损失机制，以开发特定应用的骨移植物。关于CaP基材料的受控降解行为的基本信息，以确定最佳的材料组成，可以帮助我们根据应用需求设计和定制可吸收的组织工程骨替代物。本研究的目的是验证我们的中心假设，即CaP基陶瓷的化学和微观结构可以改变这些材料的强度损失。我们的初步数据表明，微量元素（掺杂剂）可以对CaP的物理和机械性能产生显着影响。细胞与物质的相互作用也会受到微量元素的影响。具体目的是：1）通过合成、加工、表征以及体外和体内骨细胞-材料相互作用，研究具有三种不同钙磷比（1.25：1、1.33：1和1.5：1）的纳米CaP的作用。2)确定四种掺杂剂，锌，镁，硅，锶的氧化物在单一和多元素的组合物，沿着与三个钙磷陶瓷（Ca：P = 1.25：1，1.33：1和1.5：1）在体外和体内的再吸收的影响。3)使用快速成型技术开发3D互连定制孔隙度CaP结构，平均孔径为300微米，孔隙率为30和60体积%，并验证孔隙度对其性能的影响，并研究体外和体内相互作用。为了实现这些目标，我们将进行一系列的研究，包括单元素和多元素掺杂的纳米CaPs的合成，表征其化学，物理和机械性能，以及在大鼠和家兔模型中的体外和体内强度损失行为。据设想，所提出的研究的结果将导致开发具有定制降解动力学的CaP，其可用于脊柱融合、上颌骨和颅面植入物以及小规模骨缺损应用。 公共卫生相关性骨移植用可吸收磷酸钙陶瓷 磷酸钙基陶瓷因其良好的生物相容性而被广泛应用于硬组织工程中。本研究的目的是验证我们的中心假设，即磷酸钙（CaP）基陶瓷的化学和微观结构可以改善这些材料的强度损失。据设想，所提出的研究的结果将导致开发具有定制降解动力学的CaP，其可用于脊柱融合、上颌骨和颅面植入物以及小规模骨缺损应用。