Resorbable Calcium Phosphate Ceramics for Bone Graft.

用于骨移植的可吸收磷酸钙陶瓷。

• 批准号: 7885792
• 负责人: SUSMITA BOSE
• 金额: $ 23.42万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7885792
• 关键词: Autologous Transplantation; Behavior; Biodegradation; Biological; Bone Growth; Bone Regeneration; Bone Substitutes; Bone Tissue; Bone Transplantation; Bone remodeling; Cells; Ceramics; Cereals; Characteristics; Chemicals; Chemistry; Clinical; Data; Defect; Development; Elements; Face; Goals; Harvest; Healed; Human; Implant; In Vitro; Kinetics; Knowledge; Lead; Length; Magnesium; Malignant Bone Neoplasm; Mechanics; Modeling; Operative Surgical Procedures; Oryctolagus cuniculus; Osteoblasts; Osteoclasts; Osteoporosis; Oxides; Physiologic calcification; Porosity; Process; Property; Rattus; Research; Research Project Grants; Sampling; Series; Silicon; Site; Spinal; Spinal Fusion; Strontium; Structure; Testing; Time; Tissue Engineering; Trace Elements; Transplanted tissue; Zinc; abstracting; base; biomaterial compatibility; bone; bone cell; bone healing; calcium phosphate; cell growth; craniomaxillofacial; design; healing; in vivo; nanoparticle; nanopowder; nanoscale; novel; physical property; reconstruction; repaired; scaffold; success

Title: Resorbable Calcium Phosphate Ceramics for Bone Graft Abstract Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. There is a need for the development of biodegradable ceramic materials with controlled degradation kinetics that will act as a scaffold and support bone remodeling. Our long range goal is to elucidate strength loss mechanism in CaP based material and scaffold to develop bone graft for specific application. Fundamental information on controlled degradation behavior of CaP based materials to identify optimal material composition can help us design and tailor resorbable tissue engineered bone replacement based on application needs. The objective of this research is to test our central hypothesis, which is chemistry and microstructure in CaP based ceramics can modify strength loss in these materials. Our preliminary data indicate that a minimum amount of trace elements (dopants) can have significant effects on physical and mechanical properties of CaPs. Cell-materials interactions can also be influenced by the presence of trace elements. The specific aims are 1) To investigate effects of nanoscale CaP with three different Ca to P ratios, 1.25:1, 1.33:1 and 1.5:1, through synthesis, processing, characterization and in vitro and in vivo bone cell-materials interactions. 2) To determine the effects of four dopants, Zinc, Magnesium, Silicon, and Strontium oxides in single and multi-element composition, along with three CaP ceramics with Ca:P = 1.25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity and verify the influence of porosity on their properties and study in vitro and in vivo interactions. In order to accomplish these aims, we will conduct a series of studies including synthesis of nanoscale CaPs with single and multi element dopants, characterize their chemical, physical and mechanical properties, and in vitro and in vivo strength loss behavior in rat and rabbit models. It is envisioned that results from the proposed study will lead to the development of CaPs with tailored degradation kinetics that can be used in spinal fusion, maxillo- and cranio-facial implants and small scale bone defect applications. Project Narrative Resorbable Calcium Phosphate Ceramics for Bone Graft Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. The objective of this research is to test our central hypothesis, which is chemistry and microstructure in Calcium phosphate (CaP) based ceramics can modify strength loss in these materials. It is envisioned that results from the proposed study will lead to the development of CaPs with tailored degradation kinetics that can be used in spinal fusion, maxillo- and cranio-facial implants and small scale bone defect applications.

标题：骨移植用可吸收磷酸钙陶瓷 摘要 磷酸钙基陶瓷由于其优异的生物相容性， 生物相容性需要开发可生物降解的陶瓷材料， 降解动力学，其将充当支架并支持骨重建。我们的长期目标是 阐明CaP基材料和支架强度损失机制，以开发骨移植物， 应用程序.用于识别CaP基材料受控降解行为的基本信息 最佳的材料组成可以帮助我们设计和定制可吸收的组织工程骨替代物 根据应用需求。这项研究的目的是检验我们的中心假设，即 CaP基陶瓷中的化学和微观结构可以改变这些材料中的强度损失。我们 初步数据表明，微量元素（掺杂剂）可对 CaP的物理和机械性能。细胞与材料的相互作用也会受到 微量元素的存在。具体目的是1）研究纳米CaP与三种 通过合成、加工、表征和体外实验， 和体内骨细胞-材料相互作用。2)为了确定四种掺杂剂，锌，镁， 硅、锶的氧化物在单元素和多元素的组合下，沿着用三种CaP陶瓷与 Ca：P = 1.25：1、1.33：1和1.5：1对体外和体内吸收的影响。3)开发3D互联定制 使用快速原型制作的多孔CaP结构，平均孔径为300微米， 体积%孔隙率，并验证孔隙率对其性能的影响，并在体外和体内进行研究 交互.为了实现这些目标，我们将进行一系列的研究，包括合成 采用单元素和多元素掺杂的纳米CaP，表征了它们的化学、物理和 机械性能，以及在大鼠和兔模型中的体外和体内强度损失行为。是 设想，从拟议的研究结果将导致开发的CaP与定制的 降解动力学，可用于脊柱融合，上颌和颅面植入物和小规模 骨缺损应用。项目叙述 可吸收性磷酸钙陶瓷骨移植材料的研究 磷酸钙基陶瓷由于其优异的生物相容性， 生物相容性这项研究的目的是检验我们的中心假设，即化学和 磷酸钙（CaP）基陶瓷中的微结构可以改变这些材料中的强度损失。是 设想，从拟议的研究结果将导致开发的CaP与定制的 降解动力学，可用于脊柱融合，上颌和颅面植入物和小规模 骨缺损应用。