Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children

少数民族儿童早年接触城市污染物对健康的影响

• 批准号: 7475096
• 负责人: FREDERICA P PERERA
• 金额: $ 119.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475096
• 关键词: 11 year old; 7 year old; 9 year old; Adolescence; Affect; African American; Age; Age-Years; Air; Allergens; Allergic; Antigens; Area; Aromatic Hydrocarbons; Aromatic Polycyclic Hydrocarbons; Asthma; Attention deficit hyperactivity disorder; Behavior assessment; Behavioral; Behavioral Paradigm; Biological; Biological Markers; Birth; Blood; Blood specimen; Boxing; CYP1A1 gene; Canis familiaris; Carbon Black; Central City; Child; Child Behavior; Child health care; Childhood; Childhood Asthma; Chlorpyrifos; Clinical; Clinical assessments; Cognitive; Cognitive deficits; Collection; Communities; Complex; Condition; Cotinine; Data; Demographic Factors; Development; Diagnosis; Diagnostic; Dictyoptera; Disease; Dust; End Date; Endotoxins; Enrollment; Environmental Health; Environmental Pollution; Equipment and supply inventories; Ethnic Origin; Evaluation; Exhalation; Exposure to; Family; Felis catus; Fetal Growth; Funding; Future; GSTM1 gene; GSTP1 gene; Genotype; Grant; Growth; Head circumference; Health; Heavy Metals; Height; Home environment; Hour; House Dust; Household; Housing; IgE; Immunoglobulins; Impairment; Indium; Individual; Insecticides; Laboratories; Latina; Learning; Leukotrienes; Life; Low income; Measurement; Measures; Mercury; Metals; Minority; Molds; Molecular; Monitor; Mothers; Motor; Mus; Neurotoxins; New York City; Newborn Infant; Numbers; Nursery Schools; Outcome; Outcome Assessment; Overweight; Parents; Pathogenesis; Performance; Pesticides; Physicians; Plasma; Polycyclic Hydrocarbons; Pregnancy; Prevention; Principal Investigator; Problem behavior; Production; Pulmonary function tests; Purpose; Pyrenes; Questionnaires; Range; Rate; Recording of previous events; Recruitment Activity; Reporting; Research; Research Personnel; Respiratory physiology; Risk; Risk Factors; Sampling; Schools; Series; Social Environment; Specimen; Symptoms; System; TNFRSF5 gene; Testing; Time; Toxicant exposure; Trace metal; United States Environmental Protection Agency; Urine; Visit; Washington; Weight; Wheezing; Woman; air monitoring; air sampling; airway inflammation; base; cohort; cost; cytokine; developmental disease; emotion regulation; experience; fluorouracil/melphalan/tamoxifen; follow-up; gene environment interaction; glutathione S-transferase M1; glutathione S-transferase pi; inner city; instrument; interdisciplinary approach; isoprostaglandin F2alpha type-III; lymphocyte proliferation; neurobehavioral; neurodevelopment; neurotoxic; pollutant; postnatal; prenatal; prenatal exposure; programs; promoter; psychosocial; pyrene; pyroglyphid; respiratory; response; sample collection; size; stem; toxicant; urinary

DESCRIPTION (provided by applicant): The major objective of the proposed research is to study the impact of early-life exposures to common urban pollutants on neurobehavioral development and asthma in a sample of children living in three low-income, minority communities of New York City (Central Harlem, Washington Heights and the South Bronx). Using a molecular epidemiologic approach with monitoring, biomarkers, and clinical assessments at serial time points, we will extend our study of African-American and Latina urban mothers and children in order to follow the cohort through child age 11 years to assess the longer-term impact of exposures on child health and developmental outcomes. The exposures of concern include airborne polycyclic aromatic hydrocarbons (PAHs) and orgnaophosphate pesticides such as chlorpyrifos (CPF). The first Specific Aim (Neurodevelopmental) builds on our prior findings and proposes to evaluate relationships between early exposures (PAHs and CPF) and longer-term neurodevelopment, in order to assess the persistence of neurotoxic effects into the school years, identify effects that may emerge over time, and delve more deeply into the behavioral domains to better understand the significance of behavior problems observed in the preschool years. The second aim (Asthma) also builds on our previous findings with respect to risk factors for asthma. We will repeat the assessment of immunoglobulin (lg)E at ages 5, 7, and 9 and obtain measures of lung function and airway inflammation, and a physician-diagnosis of asthma between ages 5 and 7 years. We will also assess the association between becoming overweight in the first 5 years of life and the development of IgE, airway inflammation, and asthma in childhood. The research will consider the effect of known determinants of disease and potential confounders, including other toxic exposures and demographic factors. By using a multidisciplinary approach to understand the complex pathogenesis of developmental disorders and asthma that impose such a heavy burden on inner-city children, we anticipate that the proposed research will have important implications for prevention.

描述（由申请人提供）：拟议研究的主要目的是研究生活在纽约市三个低收入少数民族社区（中央哈莱姆、华盛顿高地和南布朗克斯）的儿童样本中，早期暴露于常见城市污染物对神经行为发育和哮喘的影响。使用分子流行病学方法，在连续的时间点进行监测，生物标志物和临床评估，我们将扩展我们对非洲裔美国人和拉丁美洲城市母亲和儿童的研究，以跟踪11岁儿童的队列，以评估暴露对儿童健康和发育结果的长期影响。令人关切的接触包括空气中的多环芳烃和有机磷农药，如毒死蜱。第一个具体目标（神经发育）建立在我们先前的研究结果基础上，并建议评估早期暴露（多环芳烃和CPF）与长期神经发育之间的关系，以评估神经毒性效应在学龄期间的持续性，确定可能随着时间的推移而出现的影响，并更深入地研究行为领域，以更好地理解学龄前观察到的行为问题的重要性。第二个目标（哮喘）也建立在我们以前关于哮喘危险因素的研究结果的基础上。我们将在5岁、7岁和9岁时重复免疫球蛋白（lg）E的评估，并获得肺功能和气道炎症的测量结果，以及5至7岁之间哮喘的医生诊断。我们还将评估在生命的前5年超重与儿童期IgE、气道炎症和哮喘的发展之间的关联。该研究将考虑已知的疾病决定因素和潜在混杂因素的影响，包括其他有毒物质暴露和人口因素。通过使用多学科的方法来了解对市中心儿童造成如此沉重负担的发育障碍和哮喘的复杂发病机制，我们预计拟议的研究将对预防产生重要影响。