Exploring the effect of a low-fat diet and/or exercise on change in inflammatory

探索低脂饮食和/或运动对炎症变化的影响

• 批准号: 7470197
• 负责人: Deborah R. Young
• 金额: $ 22.3万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470197
• 关键词: Aerobic Exercise; Area; Behavior; Body Composition; Body Weight decreased; C-reactive protein; Calories; Cardiovascular Diseases; Clinical Trials; Control Groups; Coronary heart disease; Cross-Sectional Studies; Data Set; Development; Diet; Dietary Fats; Dietary intake; Disease; Exercise; Fat-Restricted Diet; Fatty acid glycerol esters; Future; Gender; Goals; High Density Lipoprotein Cholesterol; High Risk Woman; Hypotension; Individual; Inflammation; Inflammatory; Intervention; Intervention Studies; LDL Cholesterol Lipoproteins; Life Style; Lipoproteins; Measures; Numbers; Oxygen; Pattern; Physical activity; Plasma; Play; Population; Postmenopause; Protein C; Public Health; Randomized; Randomized Controlled Trials; Recommendation; Relative (related person); Research; Research Personnel; Risk; Risk Factors; Role; Sample Size; Specimen; Suggestion; Testing; Thinking; Training; Woman; Work; cardiovascular disorder risk; cardiovascular risk factor; design; diet and exercise; factor C; fitness; improved; lifestyle intervention; men; novel strategies; saturated fat; uptake

DESCRIPTION (provided by applicant): Lifestyle patterns, such as consuming a low-fat dietary pattern and regular physical activity, are associated with reduced risk of cardiovascular disease (CVD) and improvement in CVD risk factors. It is less clear how these lifestyle behaviors are associated with emerging risk factors thought to play an important role in development of CVD, such as inflammation. Cross-sectional studies indicate that vigorous physical activity is associated with lower inflammatory markers, particularly C-reactive protein (CRP). A limited number of interventions suggest that regular physical activity may reduce CRP levels, but previous studies have had small sample sizes and no control groups. In contrast, only a few cross-sectional studies have assessed associations among a low-fat diet and CRP, and there is a suggestion that dietary intakes low in fat are associated with higher CRP levels. No interventions have evaluated the effects of a low-fat diet on CRP. Thus, major questions about lifestyle patterns on CRP have not been answered: Can regular physical activity reduce CRP? Does a low-fat diet not benefit CRP? What happens if these lifestyle factors are combined? These questions are critical to answer in order to design optimal lifestyle interventions to reduce risk of CVD in high-risk populations. The data set from the Diet and Exercise for Elevated Risk (DEER) trial, a randomized, controlled trial can answer these important questions. 197 men and 180 postmenopausal women with unfavorable lipoprotein levels were randomized to a 1-year trial of a (1) low-fat diet; (2) regular physical activity; (3) diet and physical activity; (4) control. Stored specimens are available to measure plasma CRP levels. This research will determine the effects of diet and physical activity, alone and in combination, on CRP relative to the control group, and explore combinations of dietary patterns and physical activity to reduce CRP levels in high-risk individuals. This application responds to PA 06-181 by testing the feasibility of lifestyle interventions on CRP in high-risk individuals to explore a new scientific area. Public Health Relevance: Recent evidence has emerged that inflammation is a key factor in the development of coronary heart disease. There are currently no recommendations for lifestyle changes that can reduce markers of inflammation. This study will use an existing data set to test whether a low-fat diet, increased physical activity, each alone or combined, can reduce markers of inflammation. These results can help determine what the optimal lifestyle changes are necessary to reduce inflammation, with the ultimate goal of reducing risk for coronary heart disease.

描述（由申请人提供）：生活方式模式，例如食用低脂饮食模式和定期体育锻炼，与心血管疾病（CVD）的风险降低以及CVD风险因素的改善有关。这些生活方式行为与被认为在CVD的发展（例如炎症）中起重要作用的新兴风险因素如何相关。横断面研究表明，剧烈的体育活动与较低的炎症标记有关，尤其是C反应蛋白（CRP）。有限的干预措施表明，定期体育锻炼可能会降低CRP水平，但以前的研究的样本量很小，对照组没有。相比之下，只有少数横截面研究评估了低脂饮食和CRP之间的关联，并且有人建议低脂肪的饮食摄入量与较高的CRP水平有关。没有干预措施评估了低脂饮食对CRP的影响。因此，尚未回答有关CRP生活方式模式的主要问题：常规体育锻炼可以减少CRP吗？低脂饮食对CRP不利吗？如果将这些生活方式因素结合在一起会发生什么？这些问题对于为了设计最佳的生活方式干预措施以减少高风险人群中CVD的风险至关重要。饮食和锻炼的数据集升高风险（鹿）试验，一项随机，对照试验可以回答这些重要问题。 197名男性和180名绝经后女性患有不利的脂蛋白水平的女性被随机分为（1）低脂饮食的1年试验； （2）定期体育锻炼； （3）饮食和体育锻炼； （4）控制。存储的样品可用于测量血浆CRP水平。这项研究将确定饮食和体育锻炼，单独和组合对对照组的CRP的影响，并探索饮食模式和体育活动的组合，以降低高风险个体的CRP水平。该申请通过测试高危个人对CRP的生活方式干预的可行性来探索新科学领域，从而对PA 06-181做出了响应。 公共卫生相关性：最近有证据表明炎症是冠心病发展的关键因素。目前尚无关于改变生活方式的建议，可以减少炎症的标志。这项研究将使用现有数据集来测试低脂饮食，单独或合并的低脂饮食是否可以减少炎症标记。这些结果可以帮助确定减少炎症的最佳生活方式变化，其最终目标是降低冠心病的风险。