Laser surface treatment of polymeric biomaterials for enhanced cell response

聚合物生物材料的激光表面处理可增强细胞反应

基本信息

  • 批准号:
    EP/E046851/1
  • 负责人:
  • 金额:
    $ 27.53万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2007
  • 资助国家:
    英国
  • 起止时间:
    2007 至 无数据
  • 项目状态:
    已结题

项目摘要

Biotechnology has the potential to improve people's quality of life and, despite public concerns, it holds the key to a number of unmet clinical needs. Biotechnology may be the next big thing after information technology. The UK biotechnology market is today worth 4.5 billion. Estimates of future growth in the market over the next five years range from 10 to 15%. Many see this growth being driven by the increased use of inexpensive and easy to manufacture polymeric biomaterials. Many different types of polymeric biomaterials are used in medicine as implants. Their applications range from facial prostheses to tracheal tubes, from kidney and liver parts to heart components, and from dentures to hip and knee joints. This wide variety of applications is because they can be easily fabricated into many forms: fibres; textiles; films and solids. Polymeric materials may also bear a close resemblance to natural tissue components, which allows for direct bonding with other substances.Although polymer science is a rapidly developing area of research, it remains that one of the most intractable problems encountered in bio and implant technology is that the performance of a polymeric biomaterial depends on the bulk and surface properties. More often than not these are in contrast to one another as the suitability of the surface properties is compromised in favour of the bulk properties. Compounding this trade-off is the fact that for certain applications and in certain instances the surface properties of the polymeric biomaterial are simply not suited to support sufficiently the level of bioactivity required. Typically, a polymeric biomaterial implant device will often fail clinically due to a lack of direct bonding with bone; that is, insufficient biointegration (osseointegration). This means that unless the surface of the polymeric biomaterial can be altered to become biomimetic (producing a surface that can mimic a natural biological surface) and provide the necessary level of bioactivity required without having a deleterious effect on the surface's performance, then either a generally more expensive solution has to be found or the implant idea will have to shelved - often the cost of the more expensive solution is too prohibitive and the implant idea is shelved. According to Dr. Matts Andersson, R&D Manager for Nobel Biocare Inc. (a 'sounding board' for clinical applications): No more can be done to improve a biomaterial's performance by working from the surface into the bulk; it is now time to concentrate on the surface to body to start to specify materials that signal to cells. Without an effective means of altering the surface properties of polymeric biomaterials the future uses of polymeric biomaterials in implant technology will likely remain as they are today.The options currently available to scientists working in the biotechnology field for altering the surface characteristics of polymeric biomaterials for increased biocompatibility are very limited. This places a limit on the extent to which the biotechnology market can expand because the lack of an effective means to treat the surface of polymeric biomaterials places a ceiling on the number of areas into which the materials can be applied. To improve biocompatibility, existing techniques typically only change one aspect of the surface characteristics, such as roughness. Lasers on the other hand change many aspects simultaneously - one such aspect is wettability. Wettability plays a significant role in promoting cell adhesion and growth. Previous work conducted with metals and ceramics revealed that there was a relationship between wettability and biocompatibility (the surface had enhanced properties and was more active). This project will focus on investigating and developing techniques to alter the surface chemistry and topography of selected polymeric biomaterials using IR and UV lasers to generate a more biocompatible surface (possessing enhanced surface propert
生物技术有可能改善人们的生活质量,尽管公众对此表示担忧,但它掌握着一些未得到满足的临床需求的关键。生物技术可能是继信息技术之后的下一件大事。如今,英国生物技术市场价值45亿英镑。对未来五年该市场未来增长的估计在10%至15%之间。许多人认为,这种增长是由于廉价和易于制造的聚合物生物材料的使用增加所推动的。许多不同类型的聚合物生物材料在医学上用作植入物。它们的应用范围从面部假体到气管导管,从肾脏和肝脏部位到心脏部件,从假牙到髋关节和膝关节。之所以有如此广泛的应用,是因为它们可以很容易地制造成多种形式:纤维、纺织品、薄膜和固体。尽管聚合物科学是一个发展迅速的研究领域,但在生物和植入技术中遇到的最棘手的问题之一是,聚合物生物材料的性能取决于其体积和表面特性。这些通常是相互对比的,因为表面性质的适合性被有利于整体性质而折衷。使这种权衡更加复杂的事实是,对于某些应用,在某些情况下,聚合物生物材料的表面性质根本不适合充分支持所需的生物活性水平。通常,由于缺乏与骨的直接结合,聚合物生物材料植入装置通常会在临床上失败,即生物整合不足(骨整合)。这意味着,除非聚合物生物材料的表面能够被改变成仿生的(产生可以模拟自然生物表面的表面),并在不对表面性能产生有害影响的情况下提供所需的生物活性水平,否则要么必须找到通常更昂贵的解决方案,要么植入的想法将不得不搁置--通常更昂贵的解决方案的成本太高,植入的想法被搁置。诺贝尔生物医保公司的研发经理马茨·安德森博士表示:通过从表面到整体的工作来改善生物材料的性能已经无济于事;现在是时候专注于从表面到身体的研究,开始指定向细胞发出信号的材料。如果没有一种有效的手段来改变聚合物生物材料的表面特性,聚合物生物材料在植入技术中的未来应用将可能保持今天的状态。目前在生物技术领域工作的科学家可用于改变聚合物生物材料的表面特性以提高生物相容性的选择非常有限。这限制了生物技术市场可以扩大的程度,因为缺乏有效的手段来处理聚合物生物材料的表面,从而限制了材料可以应用的领域的数量。为了提高生物相容性,现有技术通常只改变表面特征的一个方面,如粗糙度。另一方面,激光同时改变了许多方面--其中一个方面就是润湿性。润湿性在促进细胞黏附和生长方面起着重要作用。之前对金属和陶瓷进行的研究表明,润湿性和生物相容性之间存在关系(表面具有增强的性能和更多的活性)。该项目将专注于研究和开发技术,以改变选定的聚合物生物材料的表面化学和表面形貌,使用红外和紫外光激光来产生更生物兼容的表面(具有增强的表面属性

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jonathan Lawrence其他文献

HISTOPATHOLOGIC EVALUATION OF PATENT DUCTUS ARTERIOSUS STENTS AFTER HYBRID PALLIATION OF HYPOPLASTIC LEFT HEART SYNDROME
  • DOI:
    10.1016/s0735-1097(10)60418-4
  • 发表时间:
    2010-03-09
  • 期刊:
  • 影响因子:
  • 作者:
    Matthew Egan;Aaron J. Trask;Peter B. Baker;Jonathan Lawrence;Elena Ladich;Renu Virmani;Sharon L. Hill;Pamela A. Lucchesi;Mark Galantowicz;John P. Cheatham;John P. Kovalchin
  • 通讯作者:
    John P. Kovalchin
Analysis of KrF excimer laser beam modification resulting from ablation under closed thick film flowing filtered water
  • DOI:
    10.1016/j.optlastec.2010.10.004
  • 发表时间:
    2011-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Colin Dowding;Jonathan Lawrence
  • 通讯作者:
    Jonathan Lawrence
CO2 laser surface patterning of nylon 6,6 and subsequent effects on wettability characteristics and apatite response
尼龙 6,6 的 CO2 激光表面图案化及其对润湿特性和磷灰石响应的后续影响
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Waugh;Jonathan Lawrence
  • 通讯作者:
    Jonathan Lawrence
Effects of closed immersion filtered water flow velocity on the ablation threshold of bisphenol A polycarbonate during excimer laser machining
  • DOI:
    10.1016/j.apsusc.2010.01.009
  • 发表时间:
    2010-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Colin Dowding;Jonathan Lawrence
  • 通讯作者:
    Jonathan Lawrence
Histopathologic Evaluation of Patent Ductus Arteriosus Stents After Hybrid Stage I Palliation Matthew J. EganAaron J. TraskPeter B. BakerJonathan Lawrence • Elena LadichRenu VirmaniSharon L. HillJohn P. Cheatham • Mark GalantowiczPamela A. LucchesiJohn P. Kovalchin
混合第一期姑息治疗后动脉导管未闭支架的组织病理学评估 Matthew J. EganAaron J. TraskPeter B. BakerJonathan Lawrence • Elena LadichRenu VirmaniSharon L. HillJohn P. Cheatham • Mark GalantowiczPamela A. LucchesiJohn P. Kovalchin
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Matthew Egan;A. Trask;Jonathan Lawrence;Sharon L. Hill;Cheatham M. Galantowicz;P. Lucchesi;J. Kovalchin;Peter B. Baker;Ladich R. Virmani
  • 通讯作者:
    Ladich R. Virmani

Jonathan Lawrence的其他文献

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