Integration of Mixtures Toxicology, Toxicogenomics, and Statistics

混合物毒理学、毒理基因组学和统计学的整合

• 批准号: 7459512
• 负责人: Chris Gennings
• 金额: $ 21.72万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7459512
• 关键词: Toxicogenomics; Toxicology; statistics

DESCRIPTION (provided by applicant) The objective of this training grant is to train biostatisticians to work in interdisciplinary collaborative teams addressing the problems associated with explaining the effects of chemical mixtures or in the area of toxicogenomics. A key to the success of this venture is the joining of the efforts of key scientists (genomic or mixtures toxicologists, risk assessors, environmental epidemiologists and biostatisticians) in the fileds of chemical mixtures or toxicognemoics with trainees from a Department Of Biostatistics. The goal is for trainees to gain an understanding of and experience working on statistical issues for two important areas of toxicology: mixtures toxicology and toxicogenomics. These trainees will be qualified to hold unique positions in governmental agencies, academia, and industry where properly evaluating risks associated with relevant chemical exposures is becoming increasingly important. The trainees will be Ph.D. students or postdoctoral students in the Department of Biostatistics at the Medical College of Virginia campus of Virginia Commonwealth University (VCD), where they will pursue pre- or postdoctoral training in the discipline of biostatistics. Additional expertise will be achieved through work on dissertation/research topics that are pertinent to the field of mixtures or toxicogenomics and through collaborative work with toxicologists and/or risk assessors actively working in the area of interest. Through these research projects, students will gain experience collaborating with a team of experts working on studies involving chemical mixtures or toxicogenomics. The trainees will assist in the design of studies, conduct appropriate power analyses, analyze resulting data, write reports for the preceptor with proper interpretation of the results, and participate in a collaborative team to produce one or more manuscripts for peer-review publication. In addition, the trainees will collaborate with biostatisticians who are developing statistical methodology for issues involved in the design and analysis of data resulting from chemical mixture studies or microarray studies. BACKGROUND This proposal reflects a continuation of an ongoing and unique training program on statistical methods for the toxicology of chemical mixtures. The proposed program incorporates a new and additional emphasis on toxicogenomics of mixtures. The proposal also adds a postdoctoral position to the program, supplementing the current five pre-doctoral trainees.

描述（由申请人提供） 该培训补助金的目的是培训生物统计学家在跨学科合作团队中工作，解决与解释化学混合物的影响或毒理基因组学领域相关的问题。 该项目成功的关键是将化学混合物或毒物学领域的关键科学家（基因组或混合物毒理学家、风险评估员、环境流行病学家和生物统计学家）与生物统计学系的受训人员共同努力。目标是让受训者了解毒理学两个重要领域的统计问题并积累工作经验：混合物毒理学和毒理基因组学。这些受训人员将有资格在政府机构、学术界和工业界担任独特的职位，在这些机构中，适当评估与相关化学品接触有关的风险变得越来越重要。 学员将获得博士学位。弗吉尼亚联邦大学（VCD）弗吉尼亚医学院生物统计学系的学生或博士后学生，在那里他们将接受生物统计学学科的博士前或博士后培训。 额外的专业知识将通过与混合物或毒理基因组学领域相关的论文/研究主题的工作，以及通过与毒理学家和/或风险评估员积极在感兴趣的领域工作的合作来实现。通过这些研究项目，学生将获得经验，与专家团队合作，研究涉及化学混合物或毒理基因组学。学员将协助研究设计，进行适当的功率分析，分析结果数据，为导师撰写报告，并对结果进行适当的解释，并参加一个协作团队，为同行评审出版物制作一份或多份手稿。 此外，受训人员将与生物统计学家合作，他们正在为化学混合物研究或微阵列研究产生的数据的设计和分析所涉及的问题制定统计方法。 背景 该建议反映了一个正在进行的和独特的培训计划的化学混合物毒理学的统计方法的延续。 拟议的计划纳入了一个新的和额外的重点毒物基因组学的混合物。 该提案还为该计划增加了一个博士后职位，补充了目前的五名博士前学员。