Integration of Mixtures Toxicology, Toxicogenomics, and Statistics

描述（由申请人提供） 该培训补助金的目的是培训生物统计学家在跨学科协作团队中工作，解决与解释化学混合物的影响或毒物基因组学领域相关的问题。 这项事业成功的关键是将化学混合物或毒物预测领域的关键科学家（基因组或混合物毒理学家、风险评估员、环境流行病学家和生物统计学家）与生物统计学系的学员共同努力。目标是让学员了解毒理学两个重要领域的统计问题并获得工作经验：混合物毒理学和毒物基因组学。这些学员将有资格在政府机构、学术界和工业界担任独特的职位，在这些机构、学术界和工业界，正确评估与相关化学品暴露相关的风险变得越来越重要。 受训者将是博士学位。弗吉尼亚联邦大学（VCD）弗吉尼亚医学院生物统计学系的学生或博士后学生，他们将在那里接受生物统计学学科的博士前或博士后培训。 通过与混合物或毒物基因组学领域相关的论文/研究主题的工作，以及通过与积极在感兴趣领域工作的毒理学家和/或风险评估人员的合作，将获得额外的专业知识。通过这些研究项目，学生将获得与从事化学混合物或毒物基因组学研究的专家团队合作的经验。学员将协助设计研究，进行适当的功效分析，分析结果数据，为导师撰写报告并正确解释结果，并参与协作团队编写一份或多份手稿以供同行评审出版。 此外，学员将与生物统计学家合作，生物统计学家正在开发统计方法，解决化学混合物研究或微阵列研究数据设计和分析所涉及的问题。 背景 该提案反映了关于化学混合物毒理学统计方法的持续且独特的培训计划的延续。 拟议的计划纳入了对混合物毒物基因组学的新的额外强调。 该提案还为该计划增加了一个博士后职位，以补充目前的五名博士前培训生。

DESCRIPTION (provided by applicant) The objective of this training grant is to train biostatisticians to work in interdisciplinary collaborative teams addressing the problems associated with explaining the effects of chemical mixtures or in the area of toxicogenomics. A key to the success of this venture is the joining of the efforts of key scientists (genomic or mixtures toxicologists, risk assessors, environmental epidemiologists and biostatisticians) in the fileds of chemical mixtures or toxicognemoics with trainees from a Department Of Biostatistics. The goal is for trainees to gain an understanding of and experience working on statistical issues for two important areas of toxicology: mixtures toxicology and toxicogenomics. These trainees will be qualified to hold unique positions in governmental agencies, academia, and industry where properly evaluating risks associated with relevant chemical exposures is becoming increasingly important. The trainees will be Ph.D. students or postdoctoral students in the Department of Biostatistics at the Medical College of Virginia campus of Virginia Commonwealth University (VCD), where they will pursue pre- or postdoctoral training in the discipline of biostatistics. Additional expertise will be achieved through work on dissertation/research topics that are pertinent to the field of mixtures or toxicogenomics and through collaborative work with toxicologists and/or risk assessors actively working in the area of interest. Through these research projects, students will gain experience collaborating with a team of experts working on studies involving chemical mixtures or toxicogenomics. The trainees will assist in the design of studies, conduct appropriate power analyses, analyze resulting data, write reports for the preceptor with proper interpretation of the results, and participate in a collaborative team to produce one or more manuscripts for peer-review publication. In addition, the trainees will collaborate with biostatisticians who are developing statistical methodology for issues involved in the design and analysis of data resulting from chemical mixture studies or microarray studies. BACKGROUND This proposal reflects a continuation of an ongoing and unique training program on statistical methods for the toxicology of chemical mixtures. The proposed program incorporates a new and additional emphasis on toxicogenomics of mixtures. The proposal also adds a postdoctoral position to the program, supplementing the current five pre-doctoral trainees.