Integration of Mixtures Toxicology, Toxicogenomics, and Statistics

描述(由申请人提供) 这笔培训赠款的目的是培训生物统计学家在跨学科协作小组中工作，解决与解释化学混合物的影响或在毒物基因组学领域有关的问题。这一项目成功的关键是关键科学家(基因组或混合物毒物学家、风险评估员、环境流行病学家和生物统计学家)与生物统计系的受训人员共同努力研究化学混合物或有毒物质。培训的目标是让学员了解毒物学的两个重要领域：混合物毒理学和毒物基因组学的统计问题并获得工作经验。这些受训人员将有资格在政府机构、学术界和行业担任独特的职位，在这些领域，正确评估与相关化学品暴露相关的风险正变得越来越重要。 受训者将是弗吉尼亚联邦大学(VCD)弗吉尼亚医学院生物统计学系的博士后或博士后，他们将在那里接受生物统计学学科的博士后或博士后培训。将通过与混合物或毒物基因组学领域有关的论文/研究主题的工作，以及通过与在感兴趣领域积极工作的毒物学家和/或风险评估员的协作工作，获得更多的专门知识。通过这些研究项目，学生将获得与从事涉及化学混合物或毒素基因组学研究的专家团队合作的经验。受训人员将协助设计研究，进行适当的权力分析，分析结果数据，为教师撰写适当解释结果的报告，并参加一个合作小组，制作一份或多份手稿，供同行评议出版。此外，受训者将与生物统计学家合作，后者正在为化学混合物研究或微阵列研究产生的数据的设计和分析所涉及的问题开发统计方法。 背景 这一提议反映了正在进行的关于化学混合物毒理学统计方法的独特培训方案的继续。拟议的计划纳入了对混合物毒理基因组学的新的和额外的强调。该提案还在该项目中增加了一个博士后职位，以补充目前的五名博士后实习生。

DESCRIPTION (provided by applicant) The objective of this training grant is to train biostatisticians to work in interdisciplinary collaborative teams addressing the problems associated with explaining the effects of chemical mixtures or in the area of toxicogenomics. A key to the success of this venture is the joining of the efforts of key scientists (genomic or mixtures toxicologists, risk assessors, environmental epidemiologists and biostatisticians) in the fileds of chemical mixtures or toxicognemoics with trainees from a Department Of Biostatistics. The goal is for trainees to gain an understanding of and experience working on statistical issues for two important areas of toxicology: mixtures toxicology and toxicogenomics. These trainees will be qualified to hold unique positions in governmental agencies, academia, and industry where properly evaluating risks associated with relevant chemical exposures is becoming increasingly important. The trainees will be Ph.D. students or postdoctoral students in the Department of Biostatistics at the Medical College of Virginia campus of Virginia Commonwealth University (VCD), where they will pursue pre- or postdoctoral training in the discipline of biostatistics. Additional expertise will be achieved through work on dissertation/research topics that are pertinent to the field of mixtures or toxicogenomics and through collaborative work with toxicologists and/or risk assessors actively working in the area of interest. Through these research projects, students will gain experience collaborating with a team of experts working on studies involving chemical mixtures or toxicogenomics. The trainees will assist in the design of studies, conduct appropriate power analyses, analyze resulting data, write reports for the preceptor with proper interpretation of the results, and participate in a collaborative team to produce one or more manuscripts for peer-review publication. In addition, the trainees will collaborate with biostatisticians who are developing statistical methodology for issues involved in the design and analysis of data resulting from chemical mixture studies or microarray studies. BACKGROUND This proposal reflects a continuation of an ongoing and unique training program on statistical methods for the toxicology of chemical mixtures. The proposed program incorporates a new and additional emphasis on toxicogenomics of mixtures. The proposal also adds a postdoctoral position to the program, supplementing the current five pre-doctoral trainees.