Integration of Mixtures Toxicology, Toxicogenomics and Statistics.

混合物毒理学、毒理学和统计学的整合。

• 批准号: 8267830
• 负责人: Chris Gennings
• 金额: $ 15.88万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8267830
• 关键词: Toxicogenomics; Toxicology; statistics

DESCRIPTION (provided by applicant): The objective of this training grant is to train biostatisticians to work in inter-disciplinary collaborative teams addressing the problems associated with evaluating the effects of relevant environmental chemical mixtures or in the area of toxicogenomics. A key to the success of this venture is the joining of the efforts of key scientists (genomic or mixtures toxicologists, environmental epidemiologists and biostatisticians) in the fields of chemical mixtures or toxicogenomics with trainees from a department of biostatistics. The goal is for trainees to gain an understanding of and experience working on statistical issues for these two important areas of toxicology. These trainees will be qualified to hold unique positions in governmental agencies, academia, and industry where properly evaluating risks associated with relevant chemical exposures is becoming increasingly important. The trainees will be Ph.D. students in the Department of Biostatistics at the Virginia Commonwealth University (VCU), where they will pursue pre-doctoral training in the discipline of biostatistics. Additional expertise will be achieved through work on dissertation/research topics that are pertinent to the field of mixtures or toxicogenomics and through collaborative work with toxicologists and/or environmental epidemiologists actively working in their area of interest. Through these research projects, students will gain experience collaborating with a team of experts working to understand the relationship between environmental exposures and human disease susceptibility. The trainees will assist in the design of studies, conduct appropriate power analyses, analyze resulting data, write reports with proper interpretation of the results, and participate in a collaborative team to produce one or more manuscripts for peer-review publication. In addition, the trainees will have dissertation topics developing statistical methodology for issues involved in the design and analysis of data resulting from chemical mixtures studies or high-throughput technologies. PUBLIC HEALTH RELEVANCE: The discipline of biostatistics applies statistical theory and methodology to the biological sciences. A successful biostatistician must be proficient in statistical applications, mathematical statistics and statistical computing. The objective of the training program is to enhance this proficiency by training pre-doctoral biostatisticians so that they may become experts in the design and analysis of studies of mixtures of chemicals or toxicogenomics - two important and emerging areas of toxicology.

描述（由申请人提供）：该培训补助金的目的是培训生物统计学家在跨学科合作团队中工作，解决与评估相关环境化学混合物或毒理学领域的影响相关的问题。这一项目成功的关键是化学混合物或毒理基因组学领域的主要科学家（基因组或混合物毒理学家、环境流行病学家和生物统计学家）与生物统计学系的受训人员共同努力。目标是让学员了解毒理学这两个重要领域的统计问题并获得相关工作经验。这些受训人员将有资格 在政府机构、学术界和工业界担任独特职位，适当评估与相关化学品接触相关的风险变得越来越重要。学员将获得博士学位。弗吉尼亚联邦大学（VCU）生物统计学系的学生，在那里他们将继续生物统计学学科的博士前培训。额外的专业知识将通过与混合物或毒理学领域相关的论文/研究主题的工作，并通过与积极在其感兴趣的领域工作的毒理学家和/或环境流行病学家的合作来实现。通过这些研究项目，学生将获得与专家团队合作的经验，以了解环境暴露与人类疾病易感性之间的关系。学员将协助设计研究，进行适当的功率分析，分析结果数据，编写报告，对结果进行适当的解释，并参加一个协作团队，为同行评审出版物制作一个或多个手稿。此外，学员的论文主题将是针对化学混合物研究或高通量技术产生的数据的设计和分析所涉及的问题开发统计方法。 公共卫生相关性：生物统计学学科将统计理论和方法应用于生物科学。一个成功的生物统计学家必须精通统计应用，数理统计和统计计算。培训计划的目标是通过培训博士前生物统计学家来提高这种能力，使他们成为化学品混合物或毒理基因组学研究的设计和分析专家-毒理学的两个重要和新兴领域。