Biostatistics and Bioinformatics Facility Core

项目摘要 西奈山早期环境暴露跨学科P30中心的使命是加速 基于团队科学的研究，利用健康的生命历程信息模型。生物统计学和 生物信息学设施核心(BBFC)在这一任务中发挥了关键作用，它对复杂的、有时是新颖的 中心成员产生的各种研究类型的暴露和表型数据(基础， 临床，流行病学)，同时专注于开发方法，以更好地解决我们中心的研究主题 (多重暴露/混合、压力-化学相互作用和环境的性别特定影响 曝光)。我们在这个中心强调的数据结构是多维的和复杂的-并不简单， 单一暴露与单一健康后果有关。虽然我们提供标准数据分析服务(例如，线性 模型、纵向混合效应模型、功率计算、研究分析规划)统计方法 和研究设计需要分析复杂的高维数据，这些数据出现在我们中心的许多 工作仍然是相对较新的工作，需要先进的统计技术知识和策划能力 并解释复杂的生物数据--由BBFC的教职员工维护的专业知识。核心教职员工和 研究人员从事的研究受到中心提出的问题和方法挑战的推动 我们中心核心的协作和创新。例如，我们中心独特的核心设施服务， 例如重建过去化学暴露的牙齿生物标记物(在综合健康中描述 科学设施核心)和多个执行功能领域的操作测试室(详细信息请参见 表型和环境改进剂设施核心)产生了创建新的数据分析的需求 利用这些创新措施的全部潜力的办法。核心教职员工提供 为从事环境健康科学(EHS)工作的博士后研究员提供统计和生物信息学培训 相关项目。通过核心设施提供此类服务使P30中心能够建立和维护 专门资源(例如，与评估有关的计量和高级统计方法方面的专门知识 环境混合物)。因此，为了支持P30中心的总体目标，BBFC提出了 以下具体目标：(1)确保中心项目以健全的生物统计/生物信息学为基础 设计和分析EHS数据的原则和最先进的方法；(2)执行与任务有关的任务 生物统计/生物信息学方法研究，以进一步保证所有研究和数据分析的质量 方法；及(3)协助培训生物统计/生物信息学原理及分析方法，以 中心调查人员、研究员和博士后实习生。

Project Summary The mission of Mount Sinai's Transdisciplinary P30 Center on Early Environmental Exposures is to accelerate team science based research utilizing life course–informed models of health. The Biostatistics and Bioinformatics Facility Core (BBFC) plays a key role in that mission by modeling complex, sometimes novel, exposure and phenotype data generated by center members across a wide variety of study types (basic, clinical, epidemiologic) while focusing on developing methods to better address our Center's research themes (multiple exposures/mixtures, stress-chemical interactions, and sex specific effects of environmental exposure). The data structures we emphasize in this Center are multi-dimensional and complex—not simple, single exposures related to a single health outcome. While we offer standard data analytic services (e.g., linear models, longitudinal mixed effects models, power calculations, study analysis planning) the statistical methods and study designs needed for analyzing the complex, high-dimensional data that arise in much of our Center's work are still relatively new and require knowledge of advanced statistical techniques and the ability to curate and interpret complex biologic data – expertise maintained by the faculty of the BBFC. Core faculty and researchers engage in research motivated by questions and methodological challenges that arise from center collaborations and innovations by our Center Cores. For example, our Center's unique core facility services, such as the tooth biomarker that reconstruct past chemical exposure (described in the Integrated Health Sciences Facility Core) and the operant test chamber for multiple domains of executive functioning (detailed in the Phenotyping and Environmental Modifiers Facility Core) generated the need to create novel data analytical approaches that harness the full potential of these innovative measures. Core faculty and staff provide statistical and bioinformatics training for postdoctoral fellows working on environmental health sciences (EHS) related projects. Providing such services via a core facility allows the P30 Center to build and maintain specialized resources (e.g., expertise in measuring and advanced statistical methods related to evaluation of environmental mixtures). Thus, to support the overall goals of the P30 Center, the BBFC proposes the following specific aims: (1) to ensure that Center projects are grounded in sound biostatistical/bioinformatics principles and use state-of-the-art methods for design and analysis of EHS data; (2) to conduct mission-related biostatistical/bioinformatics methods research for further quality assurance of all research and data analysis methods; and (3) to assist in the training of biostatistical/bioinformatics principles and analysis methods to Center investigators, fellows and post-doctoral trainees.