Morehouse School of Medicine Training in Genomics and Hemoglobinopathies Program

莫尔豪斯医学院基因组学和血红蛋白病培训项目

• 批准号: 7494651
• 负责人: Jonathan K. Stiles
• 金额: $ 14.89万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7494651
• 关键词: Affect; Applications Grants; Biology, Other; Blood Vessels; Caring; Clinical Research; Collaborations; Country; Data Collection; Databases; Discipline; Equipment; Experimental Designs; Faculty; Fostering; Foundations; Funding Agency; Future; Genomics; Ghana; Goals; Hematology; Hemoglobin; Hemoglobinopathies; Home environment; Individual; Infection; Inflammatory Response; Institution; Interdisciplinary Study; Laboratory Diagnosis; Life; Low income; Master of Science; Medical; Mentors; Methods; Minority; Modems; Molecular; Molecular Biology Techniques; Paper; Population; Postdoctoral Fellow; Proteomics; Publications; Recruitment Activity; Research; Research Ethics; Research Personnel; Research Project Grants; Resources; Role; Severities; Sickle Cell Anemia; Students; Techniques; Thalassemia; Training; Travel; USA Georgia; United States National Institutes of Health; Universities; Western Asia Georgia; Writing; base; career; clinical Diagnosis; college; experience; follow-up; genetic risk factor; improved; interest; international center; medical schools; nutrition; peer; programs; tool

Hemoglbbihopathies affect significant portions of the global population, mostly residing in countries with low incomes, the major goal of the Morehouse School of Medicine's- training in Genomics and Hernogldbiriopathies Program (MSM TGHP) is to train outstanding researchers in this discipline while promoting the participation of trainees from underrepresented US minority populations, particularly those affected by hernbglobiriopathies: the program will recruit and train 4 postdoctoral fellows over three years, this programwill be conducted in collaboration with the excellent MSMPh.D. in Biomedical Sciences and the Master of Clinical Research programs. The program covers travel, living and research expenses for trainees. Collaborators from University of Ghana Medical School in Accra, Ghana, Emory University and Medical College of Georgia will be included in this program. Once trainees arrive at MSM, they will engage in a research project guided by an MSM mentor,:assisted by the directors of the program and program faculty. Didactic training topics will include an overview of hemoglobin, laboratory diagnosis and clinical aspects of hemoglobinopathies, including Sickle Cell Disease and thalassemias. In the genomic course, trainees will be immersed in the application of. molecular biology techniques (Genomics/Proteomics) and use of scientific equipment. Students will be trained in scientific methods such as experimental design, data collection, database management and analysis. Mandatory training in research ethics will be included, the program will explore the molecular basis (gehomics and proteomics) of the role of nutrition, infections/inflammatory response, vascular biology and other acquiredversus inherited factors on the severity of hemoglobinopathies. trainees will be matched with mentors at MSM and at collaborating institutions to conduct research in hematology, utilizing gehomics techniques. Collaborative, multidisciplinary research will be fostered through the availability of faculty with diverse interests on an Individual basis, regular program meetings with peers and faculty, as well as participation at local and national meetings and seminars. Trainees will be expected to produce a final paper based on their project, to be submitted for presentation at a national conferenceand for .publication. Trainees will be mandated to write a re-entry grant proposal following their training using various funding agencies, including thbse available at the NIH and the Fogarty International Center. These proposals will form the foundation of their independent research careers after returning to their home country or institution. Each trainee will receive post-training follow-up from the MSM Faculty Mentor and the Program Directors. Trainees will gain experience by conducting research in a different cultural context, and will be encouraged to pursue research careers in the field of hemoglobinopathies research that involves the use of modem genomic tools. With hope, trainees will become future outstanding researcherswho strive to improve care of individuals both burdened by hemoglobinopathiesand resource disparities.

血液病影响全球人口的很大一部分，主要居住在低收入国家 收入，莫尔豪斯医学院的主要目标-基因组学和 疱疹病毒病计划(MSM TGHP)是为了培养这一学科的杰出研究人员 促进来自代表性不足的美国少数群体的受训人员的参与，特别是那些 受全球疾病的影响：该项目将在三年内招募和培训4名博士后研究员， 这项计划将与优秀的生物医学硕士博士和 临床研究项目硕士。该计划涵盖学员的旅行、生活和研究费用。 来自加纳阿克拉加纳大学医学院、埃默里大学和医学院的合作者 佐治亚大学将被包括在这个项目中。一旦学员到达MSM，他们将参与一项 由MSM导师指导的研究项目：由项目主任和项目教职员工协助。 教学培训主题将包括对血红蛋白的概述、实验室诊断和临床方面的 血红蛋白疾病，包括镰状细胞病和地中海贫血。在基因组课程中，受训者将被 沉浸在……的应用中。分子生物学技术(基因组学/蛋白质组学)和科学技术的应用 设备。学生将接受科学方法的培训，如实验设计、数据收集、 数据库管理和分析。研究道德方面的强制性培训将包括在内，该计划将 探索营养、感染/炎症作用的分子基础(地质学和蛋白质组学) 反应、血管生物学和其他后天因素与遗传因素对血红蛋白病变严重程度的影响。 受训者将与MSM的导师和合作机构的导师配对，以进行研究 血液学，利用地磁技术。将通过以下方式促进协作、多学科研究 提供个人兴趣各异的教员，与同行定期举行项目会议，以及 教职员工，以及参加地方和国家会议和研讨会。受训人员将被期望 根据他们的项目制作一篇最终论文，提交给全国会议并供 .出版。受训者将被要求在他们的培训结束后使用各种不同的方法编写一份重返社会补助金提案 资助机构，包括美国国立卫生研究院和福格蒂国际中心的资助机构。这些建议 回国后将成为他们独立研究事业的基础或 机构。每个受训人员将接受MSM学院导师和计划的培训后跟进 董事们。学员将通过在不同的文化背景下进行研究来获得经验，并将 鼓励从事血红蛋白疾病研究领域的研究工作，涉及使用 现代基因组学工具。带着希望，学员将成为未来精益求精的优秀科研人员 照顾既有血红蛋白疾病负担又有资源差距的个人。