Morehouse School of Medicine Training in Genomics and Hemoglobinopathies Program

莫尔豪斯医学院基因组学和血红蛋白病培训项目

• 批准号: 7626004
• 负责人: Jonathan K. Stiles
• 金额: $ 12.09万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7626004
• 关键词: Advisory Committees; Affect; Applications Grants; Biology; Blood Vessels; Budgets; Caring; Clinical; Clinical Research; Collaborations; Communication; Country; Data Collection; Discipline; Doctor of Philosophy; Equipment; Experimental Designs; Faculty; Fostering; Foundations; Funding Agency; Future; Genomics; Ghana; Goals; Grant; Hematology; Hemoglobin; Hemoglobinopathies; Home environment; Individual; Infection; Inflammatory Response; Institution; Interdisciplinary Study; Internet; Laboratory Diagnosis; Life; Low income; Master of Science; Mentors; Methods; Minority; Molecular; Molecular Biology Techniques; Pamphlets; Paper; Population; Postdoctoral Fellow; Printing; Process; Proteomics; Publications; Qualifying; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Role; Severities; Sickle Cell Anemia; Site; Students; System; Techniques; Thalassemia; Training; Training Activity; Travel; United States National Institutes of Health; Universities; Update; Work; Writing; base; career; design; experience; follow-up; genetic risk factor; improved; interest; international center; medical schools; meetings; nutrition; peer; programs; symposium; tool

DESCRIPTION (provided by applicant): Hemoglobinopathies affect significant portions of the global population, mostly residing in countries with low incomes. The major goal of the Morehouse School of Medicine's Training in Genomics and Hemoglobinopathies Program (MSM TGHP) is to train outstanding researchers in this discipline while promoting the participation of trainees from underrepresented US minority populations, particularly those affected by hemoglobinopathies. The program will recruit and train 4 postdoctoral fellows over three years. This program will be conducted in collaboration with the excellent MSM Ph.D. in Biomedical Sciences and the Master of Clinical Research programs. The program covers travel, living and research expenses for trainees. Collaborators from University of Ghana Medical School in Accra, Ghana, Emory University and Medical College of Georgia will be included in this program. Once trainees arrive at MSM, they will engage in a research project guided by an MSM mentor, assisted by the directors of the program and program faculty. Didactic training topics will include an overview of hemoglobin, laboratory diagnosis and clinical aspects of hemoglobinopathies, including Sickle Cell Disease and Thalassemias. In the genomic course, trainees will be immersed in the application of molecular biology techniques (Genomics/Proteomics) and use of scientific equipment. Students will be trained in scientific methods such as experimental design, data collection, explore the molecular basis (genomics and proteomics) of the role of nutrition, infections/inflammatory response, vascular biology and other acquired versus inherited factors on the severity of hemoglobinopathies. Trainees will be matched with mentors at MSM and at collaborating institutions to conduct research in hematology, utilizing genomics techniques. Collaborative, multidisciplinary research will be fostered through the availability of faculty with diverse interests on an individual basis, regular program meetings with peers and faculty, as well as participation at local and national meetings and seminars. Trainees will be expected to produce a final paper based on their project, to be submitted for presentation at a national conference and for publication. Trainees will be mandated to write a re-entry grant proposal following their training using various funding agencies, including those available at the NIH and the Fogarty International Center. These proposals will form the foundation of their independent research careers after returning to their home country or institution. Each trainee will receive post-training follow-up from the MSM Faculty Mentor and the Program Directors. Trainees will gain experience by conducting research in a different cultural context, and will be encouraged to pursue research careers in the field of hemoglobinopathies research that involves the use of modern genomic tools. With hope, trainees will become future outstanding researchers who strive to improve care of individuals both burdened by hemoglobinopathies and resource disparities.

描述（由申请人提供）：血红蛋白病影响全球人口的很大一部分，主要居住在低收入国家。莫尔豪斯医学院的基因组学和血红蛋白病培训计划（MSM TGHP）的主要目标是培养这一学科的优秀研究人员，同时促进来自代表性不足的美国少数民族人口的学员的参与，特别是那些受血红蛋白病影响的人。该项目将在三年内招募和培养4名博士后研究员。 该计划将与优秀的MSM博士合作进行。生物医学科学和临床研究硕士课程。该计划包括学员的旅行，生活和研究费用。 来自加纳阿克拉的加纳大学医学院、埃默里大学和格鲁吉亚医学院的合作者将被纳入该计划。一旦学员到达MSM，他们将参与由MSM导师指导的研究项目，由计划和计划教师的董事协助。 教学培训主题将包括血红蛋白概述，实验室诊断和血红蛋白病的临床方面，包括镰状细胞病和地中海贫血。在基因组学课程中，学员将沉浸在分子生物学技术（基因组学/蛋白质组学）的应用和科学设备的使用中。学生将接受科学方法的培训，如实验设计，数据收集，探索营养作用的分子基础（基因组学和蛋白质组学），感染/炎症反应，血管生物学和其他获得性与遗传性因素对血红蛋白病的严重程度。 学员将与男男性接触者和合作机构的导师相匹配，利用基因组学技术进行血液学研究。合作，多学科研究将通过教师与不同的兴趣在个人的基础上，与同行和教师定期计划会议，以及在地方和国家会议和研讨会的参与可用性促进。受训人员将根据其项目编写一份最后论文，提交全国会议并出版。受训人员将被授权在培训后使用各种资助机构（包括NIH和Fogarty国际中心提供的资助机构）撰写重返校园补助金提案。这些建议将成为他们返回祖国或机构后独立研究生涯的基础。每个学员将接受来自MSM教师导师和项目主任的培训后跟进。学员将通过在不同的文化背景下进行研究来获得经验，并将被鼓励在血红蛋白病研究领域从事研究工作，包括使用现代基因组工具。有了希望，学员将成为未来的优秀研究人员谁努力改善个人的血红蛋白病和资源差距负担的护理。