Morehouse School of Medicine Training in Genomics and Hemoglobinopathies Program

莫尔豪斯医学院基因组学和血红蛋白病培训项目

• 批准号: 7098596
• 负责人: Jonathan K. Stiles
• 金额: $ 6.1万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7098596
• 关键词: Morehouse; Medicine; Training; Genomics; Hemoglobinopathies

DESCRIPTION (provided by applicant): Hemoglobinopathies affect significant portions of the global population, mostly residing in countries with low incomes. The major goal of the Morehouse School of Medicine's Training in Genomics and Hemoglobinopathies Program (MSM TGHP) is to train outstanding researchers in this discipline while promoting the participation of trainees from underrepresented US minority populations, particularly those affected by hemoglobinopathies. The program will recruit and train 4 postdoctoral fellows over three years. This program will be conducted in collaboration with the excellent MSM Ph.D. in Biomedical Sciences and the Master of Clinical Research programs. The program covers travel, living and research expenses for trainees. Collaborators from University of Ghana Medical School in Accra, Ghana, Emory University and Medical College of Georgia will be included in this program. Once trainees arrive at MSM, they will engage in a research project guided by an MSM mentor, assisted by the directors of the program and program faculty. Didactic training topics will include an overview of hemoglobin, laboratory diagnosis and clinical aspects of hemoglobinopathies, including Sickle Cell Disease and Thalassemias. In the genomic course, trainees will be immersed in the application of molecular biology techniques (Genomics/Proteomics) and use of scientific equipment. Students will be trained in scientific methods such as experimental design, data collection, explore the molecular basis (genomics and proteomics) of the role of nutrition, infections/inflammatory response, vascular biology and other acquired versus inherited factors on the severity of hemoglobinopathies. Trainees will be matched with mentors at MSM and at collaborating institutions to conduct research in hematology, utilizing genomics techniques. Collaborative, multidisciplinary research will be fostered through the availability of faculty with diverse interests on an individual basis, regular program meetings with peers and faculty, as well as participation at local and national meetings and seminars. Trainees will be expected to produce a final paper based on their project, to be submitted for presentation at a national conference and for publication. Trainees will be mandated to write a re-entry grant proposal following their training using various funding agencies, including those available at the NIH and the Fogarty International Center. These proposals will form the foundation of their independent research careers after returning to their home country or institution. Each trainee will receive post-training follow-up from the MSM Faculty Mentor and the Program Directors. Trainees will gain experience by conducting research in a different cultural context, and will be encouraged to pursue research careers in the field of hemoglobinopathies research that involves the use of modern genomic tools. With hope, trainees will become future outstanding researchers who strive to improve care of individuals both burdened by hemoglobinopathies and resource disparities.

描述（由申请人提供）：血红蛋白病影响全球人口的大部分，主要居住在收入低的国家。 Morehouse医学学院在基因组学和血红蛋白病计划方面的培训（MSM TGHP）的主要目标是培训该学科的杰出研究人员，同时促进来自代表性不足的美国少数群体的学员的参与，尤其是那些受到血细胞症的影响。该计划将在三年内招募和培训4名博士后研究员。 该计划将与出色的MSM博士合作进行。在生物医学科学和临床研究硕士学位中。该计划涵盖了学员的旅行，生活和研究费用。 加纳，加纳，埃默里大学和佐治亚州医学院的加纳大学医学院的合作者将包括在该计划中。一旦学员到达MSM，他们将在计划和计划教师的董事协助下，在MSM导师的指导下参与研究项目。 教学培训主题将包括血红蛋白，实验室诊断和血红蛋白病的临床方面的概述，包括镰状细胞疾病和地中海贫血。在基因组课程中，学员将沉浸在分子生物学技术（基因组/蛋白质组学）和科学设备的使用中。学生将接受科学方法的培训，例如实验设计，数据收集，探讨营养，感染/炎症反应，血管生物学以及其他获得的因素与遗传因素的分子基础（基因组学和蛋白质组学）。 通过基因组技术，学员将与MSM的导师和合作机构进行研究，以进行血液学研究。合作，多学科研究将通过在个人基础上具有多种利益，与同伴和教职员工的定期课程会议以及参与当地和国家会议和研讨会的参与来培养。预计受训人员将根据其项目制作最终论文，并在全国会议上提交演讲。在使用各种资助机构的培训后，包括在NIH和Fogarty International Center的培训机构培训后，将授权受训人员撰写重新进入赠款提案。这些建议将在返回祖国或机构后构成其独立研究事业的基础。每个学员将获得MSM教师导师和计划主管的培训后跟进。学员将通过在不同的文化背景下进行研究来获得经验，并鼓励在涉及使用现代基因组工具的血红蛋白病研究领域从事研究职业。有了希望，学员将成为未来的杰出研究人员，他们努力改善因血红蛋白病和资源差异负担的人的照顾。