Morehouse School of Medicine Training in Genomics and Hemoglobinopathies Program

莫尔豪斯医学院基因组学和血红蛋白病培训项目

• 批准号: 7882695
• 负责人: Jonathan K. Stiles
• 金额: $ 1.61万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7882695
• 关键词: Affect; Applications Grants; Biology; Blood Vessels; Caring; Clinical; Clinical Research; Collaborations; Country; Data Base Management; Data Collection; Discipline; Equipment; Experimental Designs; Faculty; Fostering; Foundations; Funding Agency; Future; Genomics; Ghana; Goals; Hematology; Hemoglobin; Hemoglobinopathies; Home environment; Individual; Infection; Inflammatory Response; Institution; Interdisciplinary Study; Laboratory Diagnosis; Life; Low income; Master of Science; Mentors; Methods; Minority; Modems; Molecular; Molecular Biology Techniques; Paper; Population; Postdoctoral Fellow; Proteomics; Publications; Recruitment Activity; Research; Research Ethics; Research Personnel; Research Project Grants; Resources; Role; Severities; Sickle Cell Anemia; Students; Techniques; Thalassemia; Training; Travel; United States National Institutes of Health; Universities; Writing; base; career; experience; follow-up; genetic risk factor; improved; interest; international center; medical schools; meetings; nutrition; peer; programs; tool

Hemoglbbihopathies affect significant portions of the global population, mostly residing in countries with low incomes, the major goal of the Morehouse School of Medicine's- training in Genomics and Hernogldbiriopathies Program (MSM TGHP) is to train outstanding researchers in this discipline while promoting the participation of trainees from underrepresented US minority populations, particularly those affected by hernbglobiriopathies: the program will recruit and train 4 postdoctoral fellows over three years, this programwill be conducted in collaboration with the excellent MSMPh.D. in Biomedical Sciences and the Master of Clinical Research programs. The program covers travel, living and research expenses for trainees. Collaborators from University of Ghana Medical School in Accra, Ghana, Emory University and Medical College of Georgia will be included in this program. Once trainees arrive at MSM, they will engage in a research project guided by an MSM mentor,:assisted by the directors of the program and program faculty. Didactic training topics will include an overview of hemoglobin, laboratory diagnosis and clinical aspects of hemoglobinopathies, including Sickle Cell Disease and thalassemias. In the genomic course, trainees will be immersed in the application of. molecular biology techniques (Genomics/Proteomics) and use of scientific equipment. Students will be trained in scientific methods such as experimental design, data collection, database management and analysis. Mandatory training in research ethics will be included, the program will explore the molecular basis (gehomics and proteomics) of the role of nutrition, infections/inflammatory response, vascular biology and other acquiredversus inherited factors on the severity of hemoglobinopathies. trainees will be matched with mentors at MSM and at collaborating institutions to conduct research in hematology, utilizing gehomics techniques. Collaborative, multidisciplinary research will be fostered through the availability of faculty with diverse interests on an Individual basis, regular program meetings with peers and faculty, as well as participation at local and national meetings and seminars. Trainees will be expected to produce a final paper based on their project, to be submitted for presentation at a national conferenceand for .publication. Trainees will be mandated to write a re-entry grant proposal following their training using various funding agencies, including thbse available at the NIH and the Fogarty International Center. These proposals will form the foundation of their independent research careers after returning to their home country or institution. Each trainee will receive post-training follow-up from the MSM Faculty Mentor and the Program Directors. Trainees will gain experience by conducting research in a different cultural context, and will be encouraged to pursue research careers in the field of hemoglobinopathies research that involves the use of modem genomic tools. With hope, trainees will become future outstanding researcherswho strive to improve care of individuals both burdened by hemoglobinopathiesand resource disparities.

血红蛋白病影响全球人口的很大一部分，大多居住在低血糖国家。 收入，医学的莫尔豪斯学校的主要目标-在基因组学和 Hernogldbiriopathies计划（MSM TGHP）是培养优秀的研究人员在这一学科， 促进来自代表性不足的美国少数民族的受训人员的参与，特别是那些 受hernbglobiriopathies影响：该计划将在三年内招募和培养4名博士后研究员， 该计划将与优秀的MSMPh.D.合作进行。在生物医学科学和 临床研究硕士课程。该计划包括学员的旅行，生活和研究费用。 来自加纳阿克拉的加纳大学医学院、埃默里大学和医学院的合作者 格鲁吉亚学院将被列入该计划。一旦学员到达男男性接触者，他们将从事一个 由男男性接触者导师指导的研究项目：由项目主任和项目教师协助。 教学培训主题将包括血红蛋白的概述，实验室诊断和临床方面的 血红蛋白病，包括镰状细胞病和地中海贫血。在基因组课程中，学员将 沉浸在应用中。分子生物学技术（基因组学/蛋白质组学）和科学 设备.学生将接受科学方法的培训，如实验设计，数据收集， 数据库管理和分析。研究伦理的强制性培训将包括在内，该计划将 探索营养、感染/炎症作用的分子基础（基因组学和蛋白质组学） 反应、血管生物学和其他获得性与遗传性因素对血红蛋白病严重程度的影响。 学员将与男男性接触者和合作机构的导师配对， 血液学，利用gehomics技术。将通过以下方式促进协作性、多学科研究 在个人的基础上，教师与不同的兴趣，与同行定期计划会议的可用性， 教师，以及参加地方和国家会议和研讨会。学员将被要求 根据他们的项目编写最后论文，提交给国家会议， . publication.将要求受训人员在接受培训后，使用各种 资助机构，包括在NIH和福格蒂国际中心提供的thbse。这些建议 回国后将为他们的独立研究生涯奠定基础， 机构。每位学员将接受MSM教师导师和计划的培训后跟进 董事们。学员将通过在不同的文化背景下进行研究来获得经验，并将 鼓励从事血红蛋白病研究领域的研究事业，涉及使用 现代基因组工具。有了希望，学员将成为未来努力提高的优秀研究人员 对血红蛋白病和资源不平等的个人的护理。

项目成果

Pneumococcal infections in children with sickle cell disease before and after pneumococcal conjugate vaccines.

• DOI: 10.1182/bloodadvances.2022009643
• 发表时间: 2023-11-14
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: Adamkiewicz, Thomas, V;Yee, Marianne E. M.;Thomas, Stepy;Tunali, Amy;Lai, Kristina W.;Omole, Folashade S.;Lane, Peter A.;Yildirim, Inci
• 通讯作者: Yildirim, Inci

Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype

• DOI: 10.4137/gei.s2626
• 发表时间: 2009-07
• 期刊: Genomics Insights
• 作者: Adel Driss;Kwaku Asare;J. Hibbert;Beatrice E. Gee;Tom Adamkiewicz;Jonathan K. Stiles

Co-existence of Ventricular Septal Defect and Bronchial Asthma in Two Nigerian Children.

两名尼日利亚儿童同时患有室间隔缺损和支气管哮喘。

• DOI: 10.4137/ccrep.s4584
• 发表时间: 2010
• 期刊: Clinical medicine insights. Case reports
• 作者: Bode-Thomas,F;Hyacinth,Ih;Yilgwan,Cs
• 通讯作者: Yilgwan,Cs