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Impact/non-acid reflux/respiratory diseases/children

影响/非胃酸反流/呼吸系统疾病/儿童

基本信息

批准号：
7342470
负责人：
Rachel L Rosen
金额：
$ 12.88万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-01 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7342470
关键词：
Accounting Acids Adult Asthma Award Belief Child Child health care Childhood Chronic Clinical Investigator Clinical Research Cohort Studies Coughing Data Development Diagnosis Diagnostic tests Disease Dose Ensure Epidemiology Esophageal Etiology Evaluation Faculty Funding Gastroenterologist Gastroenterology Gastroesophageal reflux disease Goals Grant Instruction K-Series Research Career Programs Knowledge Larynx Lead Learning Lipid-Laden Macrophage Lung Lung diseases Manometry Measures Mentors Mentorship Methods Modeling Morbidity - disease rate Otolaryngology Patients Pediatrics Pepsin A Pharmaceutical Preparations Physiology Prevalence Pulmonology Quality of life Reflux Research Role Score Severities Severity of illness Social Welfare Stridor Symptoms Testing Toxin Trachea Training Training Activity airway inflammation base career electric impedance experience improved indexing member multidisciplinary new technology respiratory response statistics symposium tool

项目摘要

DESCRIPTION (provided by applicant): The candidate for this K23 Career Development Award is a pediatric gastroenterologist who specializes in esophageal physiology. The candidate's long-term career goal is to have an academic research career in pediatric gastroenterology that improves the health of children through the study of reflux-related respiratory diseases. Short-term career goals to be achieved with this award include: (1) to obtain formal training in advanced statistics and epidemiology; (2) to gain additional expertise in the use of multi-channel intraluminal impedance (pH-MII), an emerging tool for measuring gastroesophageal reflux (GER); (3) to deepen the candidate's knowledge of the relationship between GER and respiratory disease; and (4) to acquire the valuable mentorship required to ensure the candidate's progress toward becoming a R01-funded clinical investigator. The candidate's primary mentor, Dr. David Christiani, has a strong background in pulmonology and epidemiology that forms the basis for his studies of the cause-and-effect relationships between toxins and respiratory disease. The candidate's multidisciplinary mentorship team also includes faculty members with expertise in pediatric pulmonology, otolaryngology, gastroenterology, and statistics. Training activities include coursework in advanced statistics and epidemiology; participation in clinical research conferences; and didactic instruction from mentors. This application outlines the first pediatric study to determine the role of non-acid reflux in respiratory disease using two novel technologies: pH-MII and esophageal manometry with impedance. Through cross-sectional and cohort studies of children, the candidate will determine (1) the temporal relationship between non-acid reflux and respiratory symptoms; (2) the strength of association and the dose-response relationship between non-acid reflux and markers of reflux-related respiratory disease; and (3) the strength of association and the dose-response relationship between non-acid reflux and the severity of respiratory disease. Findings from this research may lead to a paradigmatic shift from acid reflux to non-acid reflux as a cause of respiratory disease. Findings from this study also may lead to improved strategies for diagnosing and treating respiratory diseases, which already account for significant morbidity in children.

描述（由申请人提供）：