Role of Cerebral Blood Flow in Nausea and Motion Sickness

描述（由申请人提供）：晕动病是一种使人衰弱的疾病，在日常生活和病理状态下影响广泛的个体。虽然它在许多临床环境中广泛存在，但仍然难以客观评估和治疗。我们小组最近的工作发现了脑血流量减少和恶心的发展之间的联系。基于这一研究和其他研究，问题出现了，即脑血流量减少在晕车的发展中起什么作用。这项工作的总体目标是确定脑血流量和晕动病发展之间的关系。为了回答这个问题，我们提出了以下具体目标：1)确定脑血流量的减少是否可以准确预测晕动病的发作；2)确定在运动刺激期间维持末潮CO2是否消除了因通气增加而导致的脑血流量减少，延长了症状出现的时间，或消除了晕动病的发展。为了达到这个目标，我们将使用两种旋转速度的离垂直轴旋转，一种已经被证明是非常恶心的，另一种是容易忍受的。我们可以比较这两种模式的反应，以确定脑血流量是否在晕车症状出现之前减少。此外，我们可以添加激发二氧化碳来维持动脉二氧化碳，并改善旋转过程中的脑血流量。这项工作的发现可以转化为重大的临床和研究进展。在脱敏训练中利用脑血流量可以减少恶心事件，极大地增强和拓宽了晕动病治疗的临床应用。对晕动病的客观测量方法的发展将有助于更好地了解其机制。公共卫生相关性：本研究的目的是了解脑血流量与晕车发展之间的关系。通过了解脑血流量减少与恶心发生的关系，可能会开发出新的诊断和治疗方法。

DESCRIPTION (provided by applicant): Motion sickness is a debilitating condition that affects a wide range of individuals in both daily life and in pathological conditions. While it is widely seen in many clinical settings, it remains difficult to objectively evaluate and treat. Recent work by our group has found a connection between decreases in brain blood flow and the development of nausea. Based on this and other research, the question arises as to what role does decreased brain blood flow play in the development of motion sickness. The overall goal of this work is to determine the relationship between brain blood flow and the development of motion sickness. To answer this question we are proposing the following specific aims: 1) Determine if decreases in brain blood flow can accurately predict the onset of motion sickness; 2) Determine if maintaining end tidal CO2 during a motion stimulus eliminates the reduction in cerebral blood flow due to increased ventilation and extends time to symptoms or eliminates the development of motion sickness. To achieve this goal we will use off vertical axis rotation at two rotation speeds, one which has been shown to be very nauseogenic and one which is easily tolerated. We can compare the response of these two paradigms to determine if brain blood flow decreases prior to motion sickness symptoms. In addition we can add inspired CO2 to maintain arterial CO2 and improve brain blood flow during rotation. The findings of this work could translate into significant clinical and research advancements. Using brain blood flow during desensitization training could reduce aversive events and greatly enhance and broaden the clinical applications of motion sickness treatments. The development of an objective measure of motion sickness would allow for better understanding of the mechanisms. PUBLIC HEALTH RELEVANCE: The goal of this research is to understand the relationship between brain blood flow and the development of motion sickness. By understanding how reductions in cerebral blood flow are related to the development of nausea, new diagnostic and treatment methods may be developed.