Role of Cerebral Blood Flow in Nausea and Motion Sickness

描述(由申请人提供)：晕动病是一种使人虚弱的疾病，在日常生活和病理条件下都会影响到广泛的个人。虽然它在许多临床环境中被广泛看到，但仍然很难客观地评估和治疗。我们团队最近的研究发现，脑血流量减少与恶心的发生之间存在联系。基于这项研究和其他研究，出现了一个问题，即脑血流量减少在晕动病的发展中扮演了什么角色。这项工作的总体目标是确定脑血流和运动病发展之间的关系。为了回答这个问题，我们提出了以下具体目标：1)确定脑血流量减少是否可以准确预测晕动病的发生；2)确定在运动刺激期间维持呼气末二氧化碳是否可以消除由于增加通风而导致的脑血流量减少，并延长症状出现的时间或消除晕动病的发展。为了实现这一目标，我们将在两种旋转速度下使用垂直轴旋转，其中一种已被证明非常恶心，另一种很容易耐受。我们可以比较这两种模式的反应，以确定脑血流量是否在晕车症状之前减少。此外，我们可以添加吸入二氧化碳来维持动脉二氧化碳，并在旋转过程中改善脑血流。这项工作的发现可能转化为重大的临床和研究进展。在脱敏训练中使用脑血流可以减少厌恶事件，极大地提高和拓宽运动病治疗的临床应用。开发一种客观的晕动病测量方法将有助于更好地了解晕动病的机制。公共卫生相关性：这项研究的目标是了解脑血流与晕动病的发展之间的关系。通过了解脑血流量减少与恶心发展的关系，可能会开发出新的诊断和治疗方法。

DESCRIPTION (provided by applicant): Motion sickness is a debilitating condition that affects a wide range of individuals in both daily life and in pathological conditions. While it is widely seen in many clinical settings, it remains difficult to objectively evaluate and treat. Recent work by our group has found a connection between decreases in brain blood flow and the development of nausea. Based on this and other research, the question arises as to what role does decreased brain blood flow play in the development of motion sickness. The overall goal of this work is to determine the relationship between brain blood flow and the development of motion sickness. To answer this question we are proposing the following specific aims: 1) Determine if decreases in brain blood flow can accurately predict the onset of motion sickness; 2) Determine if maintaining end tidal CO2 during a motion stimulus eliminates the reduction in cerebral blood flow due to increased ventilation and extends time to symptoms or eliminates the development of motion sickness. To achieve this goal we will use off vertical axis rotation at two rotation speeds, one which has been shown to be very nauseogenic and one which is easily tolerated. We can compare the response of these two paradigms to determine if brain blood flow decreases prior to motion sickness symptoms. In addition we can add inspired CO2 to maintain arterial CO2 and improve brain blood flow during rotation. The findings of this work could translate into significant clinical and research advancements. Using brain blood flow during desensitization training could reduce aversive events and greatly enhance and broaden the clinical applications of motion sickness treatments. The development of an objective measure of motion sickness would allow for better understanding of the mechanisms. PUBLIC HEALTH RELEVANCE: The goal of this research is to understand the relationship between brain blood flow and the development of motion sickness. By understanding how reductions in cerebral blood flow are related to the development of nausea, new diagnostic and treatment methods may be developed.