Role of Cerebral Blood Flow in Nausea and Motion Sickness

描述（由申请人提供）：晕动病是一种使人衰弱的疾病，在日常生活和病理条件下影响广泛的个体。虽然它在许多临床环境中广泛存在，但仍然难以客观评估和治疗。我们小组最近的工作发现脑血流量减少与恶心的发展之间存在联系。基于这一研究和其他研究，出现了一个问题，即脑血流量减少在晕动病的发展中起着什么作用。这项工作的总体目标是确定脑血流量和运动病发展之间的关系。为了回答这个问题，我们提出了以下具体目标：1）确定脑血流量的减少是否可以准确地预测晕动病的发作; 2）确定在运动刺激期间维持呼气末二氧化碳是否消除了由于通气增加而导致的脑血流量减少，并延长了症状出现的时间或消除了晕动病的发展。为了实现这一目标，我们将使用两种旋转速度下的离垂直轴旋转，一种已被证明是非常易致炎的，另一种是容易耐受的。我们可以比较这两种模式的反应，以确定脑血流量是否在晕动病症状之前减少。此外，我们可以在旋转过程中增加吸入的CO2以维持动脉CO2并改善脑血流量。这项工作的结果可以转化为重大的临床和研究进展。在脱敏训练期间利用脑血流可以减少厌恶事件，并大大增强和拓宽晕动病治疗的临床应用。运动病的客观措施的发展将允许更好地了解的机制。公共卫生相关性：这项研究的目的是了解脑血流与运动病发展之间的关系。通过了解脑血流量的减少与恶心的发展之间的关系，可以开发新的诊断和治疗方法。

DESCRIPTION (provided by applicant): Motion sickness is a debilitating condition that affects a wide range of individuals in both daily life and in pathological conditions. While it is widely seen in many clinical settings, it remains difficult to objectively evaluate and treat. Recent work by our group has found a connection between decreases in brain blood flow and the development of nausea. Based on this and other research, the question arises as to what role does decreased brain blood flow play in the development of motion sickness. The overall goal of this work is to determine the relationship between brain blood flow and the development of motion sickness. To answer this question we are proposing the following specific aims: 1) Determine if decreases in brain blood flow can accurately predict the onset of motion sickness; 2) Determine if maintaining end tidal CO2 during a motion stimulus eliminates the reduction in cerebral blood flow due to increased ventilation and extends time to symptoms or eliminates the development of motion sickness. To achieve this goal we will use off vertical axis rotation at two rotation speeds, one which has been shown to be very nauseogenic and one which is easily tolerated. We can compare the response of these two paradigms to determine if brain blood flow decreases prior to motion sickness symptoms. In addition we can add inspired CO2 to maintain arterial CO2 and improve brain blood flow during rotation. The findings of this work could translate into significant clinical and research advancements. Using brain blood flow during desensitization training could reduce aversive events and greatly enhance and broaden the clinical applications of motion sickness treatments. The development of an objective measure of motion sickness would allow for better understanding of the mechanisms. PUBLIC HEALTH RELEVANCE: The goal of this research is to understand the relationship between brain blood flow and the development of motion sickness. By understanding how reductions in cerebral blood flow are related to the development of nausea, new diagnostic and treatment methods may be developed.