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Novel Optoacoustic Sensors with an Open Cavity Configuration

具有开放腔配置的新型光声传感器

基本信息

批准号：
8014555
负责人：
Jing Yong Ye
金额：
$ 16.38万
依托单位：
UNIVERSITY OF TEXAS SAN ANTONIO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8014555
关键词：
Address Affect Attention Be++ element Beryllium Biomedical Research Classification Clinical Detection Development Diagnosis Dimensions Disease Early Diagnosis Elasticity Elements Eye Frequencies Functional Imaging Generations Image Imaging Techniques Imaging technology Indium Investigation Lasers Lead Medical Imaging Microscopy Optics Pathology Research Personnel Resolution Signal Transduction Skin Spottings Structure Surface Techniques Technology Testing Tissues Transducers Ultrasonic Transducer Ultrasonography Validation acoustic imaging attenuation base cardiovascular imaging clinical Diagnosis computerized data processing design and construction detector finesse improved innovation meetings melting novel novel strategies photonics prevent programs public health relevance research study response sensor simulation surface coating

项目摘要

DESCRIPTION (provided by applicant): Much effort has been devoted to the development of novel imaging technologies for obtaining comprehensive morphological and functional information of tissues at depth in the body. Optical microscopy normally provides high resolution but limited imaging depth in scattering media. In contrast, acoustic imaging enables deep tissue imaging with unsatisfactory resolution, limited by the low frequency used in conventional ultrasound detection. High resolution ultrasound imaging offers many new potential biomedical applications by using frequencies near or higher than 50 MHz. These include imaging internal structures of the eye, diagnosing skin pathologies, and characterizing vulnerable intravascular plaques. However, conventional piezoelectric material- based ultrasound detection is challenged by the difficulty of fabricating transducers in the high frequency range. Researchers have been seeking alternative approaches to piezoelectric ultrasound detection for decades. One approach for high frequency broadband detection uses a closed micro-cavity structure sandwiched by two optical reflectors. The low detection sensitivity of this optical technique has prevented it from widespread application in clinical settings. This program aims to address this long-standing challenge of sensitive high-frequency broadband ultrasound detection. An innovative optoacoustic sensor with an open optical micro-cavity is proposed using a photonic crystal structure in a total internal reflection configuration. This unique approach allows the sensor to be directly exposed to ultrasound signals without the attenuation of an intervening structure. Further, this configuration is compatible with highly elastic materials within the cavity while maintaining high finesse. This enables substantial increases in high- frequency ultrasound detection sensitivity and bandwidth beyond the most sensitive optoacoustic and piezoelectric sensors currently available. Successful development of this unique technology will have a great impact on high-resolution deep tissue morphological and functional imaging, applicable in a wide range of applications of biomedical research and clinical diagnosis. For example, the feasibility of using this proposed technology for intravascular high- resolution photoacoustic and ultrasound imaging will be explored. Novel Optoacoustic Sensors with an Open Cavity Configuration PUBLIC HEALTH RELEVANCE An innovative optoacoustic sensor with an open optical micro-cavity is proposed using a photonic crystal structure in a total internal reflection configuration. This unique approach will enable substantial increases in high-frequency ultrasound detection sensitivity and bandwidth beyond the most sensitive optoacoustic and piezoelectric sensors currently available. Successful development of this unique technology will have a great impact on high-resolution deep tissue morphological and functional imaging, applicable in a wide range of applications of biomedical research and clinical diagnosis.

描述（由申请人提供）：大量的努力致力于开发新的成像技术，以获得身体深处组织的全面形态和功能信息。光学显微镜通常在散射介质中提供高分辨率但有限的成像深度。相比之下，声学成像能够实现具有不令人满意的分辨率的深层组织成像，这受到常规超声检测中使用的低频的限制。高分辨率超声成像通过使用接近或高于50 MHz的频率提供了许多新的潜在生物医学应用。这些包括眼睛的内部结构成像，诊断皮肤病理，并表征脆弱的血管内斑块。然而，传统的基于压电材料的超声检测受到在高频范围内制造换能器的困难的挑战。几十年来，研究人员一直在寻找压电超声检测的替代方法。一种用于高频宽带检测的方法使用夹在两个光学反射器之间的封闭微腔结构。这种光学技术的低检测灵敏度阻碍了其在临床环境中的广泛应用。该计划旨在解决敏感的高频宽带超声检测这一长期存在的挑战。提出了一种新型的开放式光学微腔光声传感器，该传感器采用光子晶体全内反射结构。这种独特的方法允许传感器直接暴露于超声信号，而不会受到介入结构的衰减。此外，该构造与腔内的高弹性材料相容，同时保持高精细度。这使得能够大幅增加高频超声检测灵敏度和带宽，超过目前可用的最灵敏的光声和压电传感器。这一独特技术的成功开发将对高分辨率深部组织形态和功能成像产生巨大影响，适用于生物医学研究和临床诊断的广泛应用。例如，将探索将该提议的技术用于血管内高分辨率光声和超声成像的可行性。具有开放腔结构的新型光声传感器公共卫生相关性提出了一种具有开放光学微腔的创新光声传感器，其使用全内反射结构中的光子晶体结构。这种独特的方法将使高频超声检测灵敏度和带宽大大增加，超过目前最灵敏的光声和压电传感器。这一独特技术的成功开发将对高分辨率深部组织形态和功能成像产生巨大影响，适用于生物医学研究和临床诊断的广泛应用。