Immune Tolerance Network: Kidney, Liver and Bone Marrow Transplantation

免疫耐受网络：肾、肝和骨髓移植

• 批准号: 7950513
• 负责人: JEFFREY A BLUESTONE
• 金额: $ 291.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950513
• 关键词: Immune; Tolerance; Network; Kidney; Liver

The Immune Tolerance Network is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses and graft rejection. The ITN conducts clinical trials that include novel tolerance-inducing therapies for liver transplantation, kidney transplantation, bone marrow transplantation, stem cell transplantation, pancreatic islet transplantationand the prevention of graft rejection. In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies, and to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans.

免疫耐受网络致力于新型耐受诱导疗法的临床评估，这些疗法将“重新教育”免疫系统，以消除有害的免疫反应和移植物排斥。 ITN 开展的临床试验包括针对肝移植、肾移植、骨髓移植、干细胞移植、胰岛移植和预防移植物排斥的新型耐受诱导疗法。此外，为了了解候选疗法的潜在作用机制并监测耐受性，ITN 建立了最先进的核心实验室设施来进行综合机制研究，并开发和评估标记物和测定法，以测量人类耐受性的诱导、维持和丧失。