Laboratory Animal & Comparative Medicine Training

描述（由申请人提供）：对受过生物医学科学家培训的兽医的需求已经得到了充分的证明。我们在此请求资助四名dvm后研究员进行三年的研究培训。研究培训的最佳情况是，合格和积极的受训者在经验丰富、富有成效和资金充足的科学家导师的实验室工作。这些导师传授知识、工作习惯、沟通技巧和研究技能，使受训者能够成功地成为独立的比较医学科学家和多学科研究小组的贡献者。这些科学家将熟练使用动物模型和应用细胞、免疫学、分子、基因组或翻译方法来解决对人类健康有重要意义的问题。通过暑期奖学金项目和多种其他策略确定的有前途的学员被鼓励申请这个博士后奖学金项目。所有学员将被要求进入维克森林大学研究生院攻读博士学位。学员通常会选择病理学系分子和细胞病理生物学博士课程或分子医学和转化科学多学科博士课程。后一个项目是由维克森林大学建立的，以应对对在转化科学方面受过培训的医学博士和副博士的需求增加，更具体地说，是为了参与由新的临床和转化科学奖励计划（CTSA）支持的转化科学项目。培训教员有26人，其中19人有独立的研究项目和基金。此外，有15人被任命为比较医学，其中11人是副医学博士。受训者将从一组资金充足、经验丰富的科学家和教育工作者中选择一名导师，并被指派一名具有与受训者的研究项目相关专业知识的副导师。助理导师是指没有独立研究经费和/或培训经验有限，但有共同研究经费的教员。这种共同指导的方法将使初级教师在团队环境中获得培训经验，为他们成为下一代导师做好准备。研究重点有五个领域：1)动脉粥样硬化和心血管疾病；2)癌症生物学；3)肥胖和糖尿病；4)神经生物学和药物滥用；5)妇女健康和生殖医学。重要的新研究资源和机会包括：1)即将从加州大学洛杉矶分校迁至WFUSM， 2)维克森林再生医学研究所的世界级组织工程项目，3)新成立的维克森林大学转化科学研究所（WFU TSI）。除了必修课程外，所有学员还将参加每周的研究研讨会和期刊俱乐部。我们相信兽医在制定预防和治疗人类疾病的战略方面发挥着关键作用。因此，NCRR为此目的资助兽医的高质量培训对生物医学研究事业的持续成功至关重要。

DESCRIPTION (provided by applicant): The need for veterinarians trained as biomedical scientists has been well-documented. We request here funding to support four post-DVM fellows for three years of research training. The optimal situation for research training exists when qualified and motivated trainees work in the laboratories of experienced, productive and well-funded scientist mentors. Such mentors impart the knowledge, work habits, communicative skills and research skills enabling trainees to succeed as independent comparative medicine scientists and as contributors to multidisciplinary research teams. These scientists will be skilled both in the use of animal models and the application of cellular, immunologic, molecular, genomic or translational approaches to address questions of human health significance. Promising trainees identified through a summer fellowship program and multiple other strategies are encouraged to apply to this postdoctoral fellowship program. All trainees will be expected to enroll in the Graduate School of Wake Forest University and pursue a PhD degree. Trainees will usually choose from the Department of Pathology Ph.D. program in Molecular and Cellular Pathobiology or the multidisciplinary PhD program in Molecular Medicine and Translational Science. This latter program was established by Wake Forest University to respond to the increase in demand for MD's and DVM's trained in translational science and, more specifically, to participate in translational science programs supported by the new Clinical and Translational Science Award Program (CTSA). There are 26 members of the training faculty, of which 19 have independent research programs and funding. In addition, 15 have appointments in Comparative Medicine and 11 of these are DVM's. Trainees will choose a Mentor from among a group of well-funded and experienced scientists and educators and be assigned an Associate Mentor with expertise relevant to the trainee's research project. Associate Mentors are faculty members without independent research funding and/or with limited training experience, but with funding as co-investigators. This co-mentoring approach will allow junior faculty to gain training experience in a team setting preparing them to serve as the next generation of mentors. There are five areas of research emphasis: 1) atherosclerosis and cardiovascular disease, 2) cancer biology, 3) obesity and diabetes, 4) neurobiology and substance abuse and 5) women's health and reproductive medicine. Important new research resources and opportunities include 1) the imminent relocation of a unique multigenerational and pedigreed colony of about 500 vervet monkeys from UCLA to WFUSM, 2) a world-class program in tissue engineering at The Wake Forest Institute of Regenerative Medicine and 3) the newly-established Wake Forest University Translational Science Institute (WFU TSI). In addition to required coursework, all trainees will attend weekly research seminars and journal clubs. We believe that veterinarians play a critical role in the development of strategies for preventing and treating human diseases. Therefore, NCRR's funding of high-quality training of veterinarians for this purpose is vital to the continued success of the biomedical research enterprise.