Redox Biology and Medicine Training Program

氧化还原生物学与医学培训计划

• 批准号: 10641477
• 负责人: Cristina Maria Furdui
• 金额: $ 21.22万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641477
• 关键词: Biology; Medicine; Oxidation-Reduction; Training Programs

Project Summary This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Systems and Integrative Biology Program of the National Institute for General Medical Sciences. This grant will support predoctoral training in Redox Biology and Medicine (RBM) leading to a Ph.D. degree at Wake Forest University. The RBM Training Program is a multi-disciplinary, multi-departmental program that has as its goal the training of researchers working at the interface of biomedical sciences, biology, chemistry and physics to communicate and work across disciplines to delve into the specialized chemistry of oxidation and reduction reactions underlying the pathophysiology of many diseases. The 34 members of the RBM training faculty are diverse and highly collaborative, and include faculty from Biochemistry, Cancer Biology, Biomedical Engineering, Internal Medicine, Microbiology and Immunology, Chemistry, Biology, and Physics. Seven physician or veterinarian scientists (with MD, MD/PhD or DVM/PhD degrees) are also among the training faculty, encouraging translational science. Participating faculty represent a balance of career stages, including Assistant (10), Associate (11) and full Professors (13). Major scientific themes of the RBM Training Program include the overlapping areas of (i) oxidative modifications regulating metabolism and signal transduction pathways, (ii) redox regulation of nucleic acid metabolism and cell cycle, (iii) reactive nitrogen species biochemistry and biophysics relating to human health, and (iv) redox-linked mechanisms of disease initiation, progression and treatment. The RBM training program has a flexible curriculum built around a common core of required courses (Fundamentals of Redox Biology and Medicine, MCB 715; Omics Data: Generation, Analysis & Exploration, CABI 740; and at least one technology-specific minicourse or workshop), electives, as well as the discipline- specific courses to meet the requirements of the Ph.D. programs of the trainees. Students in the program are trained in such areas as chemical biology, omics (proteomics, lipidomics, metabolomics), biomedical engineering, enzymology, animal models of disease, mitochondrial biology and computational biology / bioinformatics as fits best to the research area of the individual and their Individual Development Plan. The training program takes advantage of the activities driven by the Center for Redox Biology and Medicine in coordination with other basic research and clinical centers at the institution, including a well-developed system of interdisciplinary seminars and retreats to promote interaction among members of the program. Students participate in trainee-focused Chalk Talks which foster development in the cross-discipline communication skills so critical to the multi-disciplinary research in this field. We also offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including careers in academia, biotechnology and pharmaceutical industries, intellectual property, and science communication and policy. The guiding principles of Diversity, Equity, and Inclusion as well as anti-racism activities are at the core of our program and present at all levels of organization (students, mentors, Executive Committee, and activities).

项目摘要 该提案为系统和 国家一般医学科学研究所的综合生物学计划。这笔赠款将支持 氧化还原生物学和医学（RBM）培训的培训，导致博士学位。维克森林大学的学位。 RBM培训计划是一个多学科的多部门计划，其目标是培训 在生物医学，生物学，化学和物理学界面上工作的研究人员进行交流 并跨学科工作，以深入研究氧化和还原反应的专门化学 许多疾病的病理生理基础。 RBM培训学院的34名成员是多样的 高度协作，包括来自生物化学，癌症生物学，生物医学工程，内部的教师 医学，微生物学和免疫学，化学，生物学和物理学。七名医生或兽医 科学家（MD，MD/PhD或DVM/PhD学位）也是培训教师 翻译科学。参加教师代表了职业阶段的平衡，包括助手（10）， （11）和完整教授（13）。 RBM培训计划的主要科学主题包括 （i）调节代谢和信号转导途径的氧化修饰的重叠区域，（ii） 氧化还原的核酸代谢和细胞周期的调节，（iii）反应性氮物种生物化学和 与人类健康有关的生物物理学以及（iv）疾病起步，进展和 治疗。 RBM培训计划具有灵活的课程，围绕着所需课程的通用核心建立 （氧化还原生物学和医学的基础，MCB 715； OMICS数据：生成，分析与探索， CABI 740;至少一个技术特定的小型或讲习班），选修课以及学科 - 特定课程满足博士学位的要求。学员的计划。该计划中的学生是 在化学生物学，奥理学（蛋白质组学，脂质组学，代谢组学），生物医学培训 工程，酶学，疾病动物模型，线粒体生物学和计算生物学 / 生物信息学最适合个人的研究领域及其个人发展计划。这 培训计划利用了由氧化还原生物学和医学中心驱动的活动 与机构的其他基础研究和临床中心的协调，包括一个发达的系统 跨学科研讨会和务虚会，以促进该计划成员之间的互动。学生 参加以学员为中心的粉笔谈话，以促进跨学科沟通技巧发展 对于该领域的多学科研究至关重要。我们还提供各种技能的特定培训 我们博士的潜在职业毕业生，包括学术界，生物技术和药物的职业 行业，知识产权以及科学传播和政策。多样性的指导原则， 公平，包容性以及反种族主义活动是我们计划的核心，并在各个层面上呈现 组织（学生，导师，执行委员会和活动）。