Redox Biology and Medicine Training Program

项目摘要 这项提案寻求为NRSA机构博士前培训补助金从系统和 国家普通医学研究所综合生物学项目。这笔赠款将支持 氧化还原生物学和医学(RBM)博士前培训导致在维克森林大学获得博士学位。 成果管理制培训计划是一个多学科、多部门的计划，其目标是培训 在生物医学、生物、化学和物理之间进行交流的研究人员 并跨学科工作，深入研究氧化和还原反应的专业化学 许多疾病的病理生理学基础。成果管理制培训学院的34名成员是不同的， 高度协作，包括来自生物化学、癌症生物学、生物医学工程、内部 医学、微生物学和免疫学、化学、生物学和物理学。七名医生或兽医 科学家(拥有MD、MD/PhD或DVM/PhD学位)也在培训人员中，这令人振奋 翻译科学。参与的教职员工代表了职业生涯阶段的平衡，包括助理(10人)， 副教授(11人)和正教授(13人)。成果管理制培训方案的主要科学主题包括 (I)氧化修饰调节新陈代谢和信号转导途径的重叠区域，(Ii) 氧化还原调节核酸代谢和细胞周期，(Iii)活性氮物种生物化学和 与人类健康有关的生物物理学，以及(Iv)与氧化还原有关的疾病发生、进展和发展机制 治疗。成果管理制培训方案围绕必修课程的共同核心建立了灵活的课程体系 (氧化还原生物学和医学基础，MCB 715；Omics数据：生成、分析和探索， CABI 740；以及至少一门专门针对技术的小型课程或研讨会)、选修课以及以下学科- 符合受训人员博士项目要求的具体课程。参加该计划的学生是 受过化学生物学、组学(蛋白质组学、脂质组学、代谢组学)、生物医学等领域的培训 工程学、酶学、疾病动物模型、线粒体生物学和计算生物学/ 生物信息学是最适合个人及其个人发展计划的研究领域。这个 培训计划利用氧化还原生物和医学中心在#年推动的活动 与该机构的其他基础研究和临床中心进行协调，包括建立完善的系统 举办跨学科研讨会和务虚会，以促进项目成员之间的互动。学生 参加以学员为中心的粉笔讲座，促进跨学科交流技能的发展 这对这一领域的多学科研究至关重要。我们还为各种各样的人提供专门的技能培训 我们博士毕业生的潜在职业，包括学术界、生物技术和制药业 产业、知识产权、科学传播和政策。《多样性指导原则》， 公平、包容以及反种族主义活动是我们方案的核心，并存在于 组织(学生、导师、执行委员会和活动)。

Project Summary This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Systems and Integrative Biology Program of the National Institute for General Medical Sciences. This grant will support predoctoral training in Redox Biology and Medicine (RBM) leading to a Ph.D. degree at Wake Forest University. The RBM Training Program is a multi-disciplinary, multi-departmental program that has as its goal the training of researchers working at the interface of biomedical sciences, biology, chemistry and physics to communicate and work across disciplines to delve into the specialized chemistry of oxidation and reduction reactions underlying the pathophysiology of many diseases. The 34 members of the RBM training faculty are diverse and highly collaborative, and include faculty from Biochemistry, Cancer Biology, Biomedical Engineering, Internal Medicine, Microbiology and Immunology, Chemistry, Biology, and Physics. Seven physician or veterinarian scientists (with MD, MD/PhD or DVM/PhD degrees) are also among the training faculty, encouraging translational science. Participating faculty represent a balance of career stages, including Assistant (10), Associate (11) and full Professors (13). Major scientific themes of the RBM Training Program include the overlapping areas of (i) oxidative modifications regulating metabolism and signal transduction pathways, (ii) redox regulation of nucleic acid metabolism and cell cycle, (iii) reactive nitrogen species biochemistry and biophysics relating to human health, and (iv) redox-linked mechanisms of disease initiation, progression and treatment. The RBM training program has a flexible curriculum built around a common core of required courses (Fundamentals of Redox Biology and Medicine, MCB 715; Omics Data: Generation, Analysis & Exploration, CABI 740; and at least one technology-specific minicourse or workshop), electives, as well as the discipline- specific courses to meet the requirements of the Ph.D. programs of the trainees. Students in the program are trained in such areas as chemical biology, omics (proteomics, lipidomics, metabolomics), biomedical engineering, enzymology, animal models of disease, mitochondrial biology and computational biology / bioinformatics as fits best to the research area of the individual and their Individual Development Plan. The training program takes advantage of the activities driven by the Center for Redox Biology and Medicine in coordination with other basic research and clinical centers at the institution, including a well-developed system of interdisciplinary seminars and retreats to promote interaction among members of the program. Students participate in trainee-focused Chalk Talks which foster development in the cross-discipline communication skills so critical to the multi-disciplinary research in this field. We also offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including careers in academia, biotechnology and pharmaceutical industries, intellectual property, and science communication and policy. The guiding principles of Diversity, Equity, and Inclusion as well as anti-racism activities are at the core of our program and present at all levels of organization (students, mentors, Executive Committee, and activities).