Redox Biology and Medicine Training Program

氧化还原生物学与医学培训计划

• 批准号: 10641477
• 负责人: Cristina Maria Furdui
• 金额: $ 21.22万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641477
• 关键词: Biology; Medicine; Oxidation-Reduction; Training Programs

Project Summary This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Systems and Integrative Biology Program of the National Institute for General Medical Sciences. This grant will support predoctoral training in Redox Biology and Medicine (RBM) leading to a Ph.D. degree at Wake Forest University. The RBM Training Program is a multi-disciplinary, multi-departmental program that has as its goal the training of researchers working at the interface of biomedical sciences, biology, chemistry and physics to communicate and work across disciplines to delve into the specialized chemistry of oxidation and reduction reactions underlying the pathophysiology of many diseases. The 34 members of the RBM training faculty are diverse and highly collaborative, and include faculty from Biochemistry, Cancer Biology, Biomedical Engineering, Internal Medicine, Microbiology and Immunology, Chemistry, Biology, and Physics. Seven physician or veterinarian scientists (with MD, MD/PhD or DVM/PhD degrees) are also among the training faculty, encouraging translational science. Participating faculty represent a balance of career stages, including Assistant (10), Associate (11) and full Professors (13). Major scientific themes of the RBM Training Program include the overlapping areas of (i) oxidative modifications regulating metabolism and signal transduction pathways, (ii) redox regulation of nucleic acid metabolism and cell cycle, (iii) reactive nitrogen species biochemistry and biophysics relating to human health, and (iv) redox-linked mechanisms of disease initiation, progression and treatment. The RBM training program has a flexible curriculum built around a common core of required courses (Fundamentals of Redox Biology and Medicine, MCB 715; Omics Data: Generation, Analysis & Exploration, CABI 740; and at least one technology-specific minicourse or workshop), electives, as well as the discipline- specific courses to meet the requirements of the Ph.D. programs of the trainees. Students in the program are trained in such areas as chemical biology, omics (proteomics, lipidomics, metabolomics), biomedical engineering, enzymology, animal models of disease, mitochondrial biology and computational biology / bioinformatics as fits best to the research area of the individual and their Individual Development Plan. The training program takes advantage of the activities driven by the Center for Redox Biology and Medicine in coordination with other basic research and clinical centers at the institution, including a well-developed system of interdisciplinary seminars and retreats to promote interaction among members of the program. Students participate in trainee-focused Chalk Talks which foster development in the cross-discipline communication skills so critical to the multi-disciplinary research in this field. We also offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including careers in academia, biotechnology and pharmaceutical industries, intellectual property, and science communication and policy. The guiding principles of Diversity, Equity, and Inclusion as well as anti-racism activities are at the core of our program and present at all levels of organization (students, mentors, Executive Committee, and activities).

项目摘要 该提案旨在为NRSA机构的博士前培训补助金提供资金， 国立普通医学科学研究所综合生物学计划。这笔资金将支持 在氧化还原生物学和医学（RBM）的博士前培训，导致博士学位。在维克森林大学获得学位。 RBM培训计划是一个多学科，多部门的计划，其目标是培训 研究人员在生物医学科学，生物学，化学和物理学的接口工作， 并跨学科深入研究氧化和还原反应的专业化学 许多疾病的病理生理学基础。成果管理制培训学院的34名成员来自不同的领域， 高度合作，包括来自生物化学，癌症生物学，生物医学工程，内部 医学、微生物学和免疫学、化学、生物学和物理学。七名医生或兽医 科学家（MD，MD/PhD或DVM/PhD学位）也在培训教师中，令人鼓舞 转化科学参与的教师代表了职业阶段的平衡，包括助理（10）， 副教授（11）和正教授（13）。成果管理制培训方案的主要科学主题包括： （i）氧化修饰调节代谢和信号转导途径，（ii） 核酸代谢和细胞周期的氧化还原调节，（iii）活性氮类生物化学和 与人类健康有关的生物物理学，以及（iv）与疾病发生、进展和 治疗成果管理制培训方案有一个围绕共同核心必修课程的灵活课程 （氧化还原生物学和医学基础，MCB 715;组学数据：生成，分析和探索， CABI 740;和至少一个技术特定的微型课程或研讨会），选修课，以及学科- 具体课程，以满足博士学位的要求。学员的方案。该计划的学生是 在化学生物学、组学（蛋白质组学、脂质组学、代谢组学）、生物医学 工程学、酶学、疾病动物模型、线粒体生物学和计算生物学/ 生物信息学最适合个人的研究领域和他们的个人发展计划。的 培训计划利用了由氧化还原生物学和医学中心推动的活动， 与该机构的其他基础研究和临床中心协调，包括完善的系统 跨学科研讨会和务虚会，以促进该计划的成员之间的互动。学生 参加以学员为中心的粉笔会谈，促进跨学科沟通技能的发展 对这一领域的多学科研究至关重要。我们还提供各种技能的具体培训， 我们博士的潜在职业毕业生，包括学术界，生物技术和制药业的职业 工业、知识产权以及科学传播和政策。多样性的指导原则， 公平，包容以及反种族主义活动是我们计划的核心，并存在于各个层面。 组织（学生，导师，执行委员会和活动）。