Development of an Intervention for Non-Suicidal Self-Injury in Young Adults

针对年轻人非自杀性自残的干预措施的开发

• 批准号: 7446481
• 负责人: Margaret S. Andover
• 金额: $ 18.77万
• 依托单位: FORDHAM UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7446481
• 关键词: Adherence; Award; Behavior; Behavior Therapy; Borderline Personality Disorder; Categories; Cessation of life; Clinical; Clinical Ethics; Clinical Research; Clinical Trials; Cognitive Therapy; Control Groups; Development; Diagnosis; Dialectical behavior therapy; Distress; Education; Effectiveness; Empirical Research; Frequencies; Goals; Grant; Individual; Injury; Intervention; K-Series Research Career Programs; Knowledge; Maintenance; Manuals; Manuscripts; Measures; Medical; Mentored Clinical Oncology Award; Mentored Clinical Scientist Award; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Modeling; Motivation; Nature; Numbers; Outcome Study; Participant; Patients; Phase; Pilot Projects; Population; Preparation; Prevalence; Purpose; Randomized; Randomized Clinical Trials; Range; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Risk; Sampling; Scientist; Self-Injurious Behavior; Severities; Shame; Social isolation; Staging; Suicide; Suicide attempt; Supervision; Symptoms; Techniques; Time; Training; Training Programs; Treatment Efficacy; Work; Writing; aged; base; career; coping; design; experience; follow-up; motivational enhancement therapy; pilot trial; psychologic; satisfaction; skills; suicidal; therapy development; treatment effect; university student; young adult

DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI), deliberate harm to the body without suicidal intent, is highly prevalent in young adults, with 1 in 10 college students engaging in over 100 episodes in their lifetimes. Consequences of NSSI are severe, including physical injury ranging in medical severity, distress from shame associated with the behavior, social isolation, psychological symptoms, and increased risk and lethality of NSSI over time, resulting in more severe injuries, suicide attempts, and even death. Despite the prevalence and significant consequences of the behavior, no empirically supported treatments specific to NSSI exist. The purpose of the research plan included in this K23 Career Development Award is to develop, implement, and evaluate an intervention specifically for NSSI in young adults, the Treatment for Self- Injurious Behaviors (T-SIB). This time-limited intervention will integrate theoretically-based strategies whose utility has been identified through empirical research, including a functional analysis of NSSI, motivational interviewing techniques, and individualized behavior therapy with the goal of reducing frequency and severity of NSSI. The research plan consists of 2 phases. During Phase 1, I will develop a comprehensive treatment manual and therapist training program for T-SIB and treat 12 patients in an open pilot trial. After further refinement of the intervention, Phase 2 will involve the treatment of 60 patients in a randomized controlled pilot study to determine the feasibility and acceptability of T-SIB, investigate change in NSSI frequency and severity between T-SIB and treatment as usual (TAU) through a 3-month follow up period, and evaluate the research design of the randomized controlled pilot study to inform both the utility and design of a larger randomized clinical trial, to be proposed as an R01 in Year 5 of the award. The training plan proposed in this application will allow me the opportunity to develop and refine the skills necessary to continue my career as a clinical scientist working with self-harming individuals. Through formal training, the proposed research plan, mentorship experiences with Drs. Miller and Spirito, and regular meetings with my consultants, all leaders in their fields, I will be able to fulfill the following training goals: 1) to gain experience in treatment development, design, and outcome studies, including the methodology and analysis of clinical trials; 2) to increase expertise in and knowledge of the phenomenology and treatment of NSSI specifically and self-harm in general in young adults; 3) to advance my education in the ethics of clinical research trials and diversity training; 4) to increase my experience in grant writing and manuscript preparation; and 5) to gain further clinical training and supervision in motivational interviewing and the treatment of self-harming individuals. This K23 Award will advance my training and is the logical next step in preparing me for a career as an independent clinical researcher specializing in self-harm behaviors.

描述（由申请人提供）：非自杀性自伤（NSSI）是一种没有自杀意图的故意伤害身体的行为，在年轻人中非常普遍，每10个大学生中就有1个在他们的一生中发生过100多次。自伤的后果是严重的，包括医学上严重程度的身体伤害，与行为相关的羞耻感带来的痛苦，社会孤立，心理症状，随着时间的推移，自伤的风险和致命性增加，导致更严重的伤害，自杀企图，甚至死亡。尽管自伤行为的流行和显著的后果，没有经验支持的治疗方法专门针对自伤存在。本次K23职业发展奖的研究计划的目的是开发、实施和评估一种专门针对年轻人自伤的干预措施，即自我伤害行为治疗（T-SIB）。这种有时间限制的干预将整合基于理论的策略，这些策略的效用已通过实证研究确定，包括自伤的功能分析、动机性访谈技术和个性化行为治疗，目的是减少自伤的频率和严重程度。研究计划分为两个阶段。在第一阶段，我将为T-SIB制定一个全面的治疗手册和治疗师培训计划，并在一个开放的试点试验中治疗12名患者。在进一步完善干预措施后，第二阶段将涉及60例患者的随机对照试点研究，以确定T-SIB的可行性和可接受性，通过3个月的随访期调查T-SIB与常规治疗（TAU）之间自伤频率和严重程度的变化，并评估随机对照试点研究的研究设计，为更大规模随机临床试验的实用性和设计提供信息。在第5年获提名为R01。这份申请中提出的培训计划将使我有机会发展和完善必要的技能，以继续我作为一名临床科学家的职业生涯，研究自我伤害的个体。通过正式的培训，提出的研究计划，与博士的指导经验。Miller和Spirito，并定期与我的顾问会面，他们都是各自领域的领导者，我将能够完成以下培训目标：1)获得治疗开发，设计和结果研究的经验，包括临床试验的方法和分析；2)增加对青少年自伤的现象学和治疗的专业知识和知识；3)推进我在临床研究试验伦理和多样性培训方面的教育；4)增加我在基金写作和稿件准备方面的经验；5)在动机性访谈和自我伤害个体的治疗方面获得进一步的临床培训和监督。这个K23奖将提升我的训练水平，是为我的职业生涯做准备的合乎逻辑的下一步，我将成为一名独立的临床研究员，专门研究自残行为。