Sleep disturbance and inhibitory control as proximal predictors of suicidal ideation and behavior: A daily diary and actigraphy study of young adults

睡眠障碍和抑制控制作为自杀意念和行为的近端预测因子：一项针对年轻人的每日日记和体动记录仪研究

• 批准号: 10307152
• 负责人: Margaret S. Andover
• 金额: $ 21.47万
• 依托单位: FORDHAM UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10307152
• 关键词: Accident and Emergency department; Age; Arousal and Regulatory Systems; Attention; Behavior; Behavioral; Biological; Cause of Death; Cessation of life; Clinical; Communities; Data; Economically Deprived Population; Feeling suicidal; Incidence; Individual; Longevity; Mediating; Mediation; Mental Depression; Mental disorders; Methodology; Methods; Modeling; Outcome; Patient Self-Report; Persons; Population Heterogeneity; Predictive Factor; Public Health; Research; Research Domain Criteria; Risk; Risk Factors; Sampling; Self-Injurious Behavior; Severities; Sleep; Sleep Disorders; Sleep disturbances; Suicide; Suicide attempt; Time; Underserved Population; United States; United States National Institutes of Health; Wakefulness; actigraphy; age group; aged; biomarker identification; clinically relevant; cognitive control; cognitive system; diaries; ethnic diversity; high risk; ideation; modifiable risk; negative affect; poor sleep; predictive marker; prospective; racial diversity; sleep quality; social disadvantage; social group; suicidal behavior; suicidal risk; suicide rate; young adult

Project Summary/Abstract Suicide is the second leading cause of death among young adults aged 18-34 in the United States. There is an urgent need to identify clinically-relevant behavioral factors that are predictive of suicide risk across diverse populations, as well as to identify the mechanisms through which these factors confer risk. Disturbed sleep has been identified as a proximal risk factor for suicide outcomes, including ideation and attempts. Importantly, sleep is modifiable, making it a critical focus of research attention. The proposed study will utilize daily diary and actigraphy methodologies over 21 days to examine the effects of sleep disturbance—a specific, modifiable, immediately proximal risk factor for suicide outcomes in young adults—on next day suicidal ideation and attempt behavior. In addition, we will examine inhibitory control as a time-varying mechanism through which daily sleep disturbance may confer proximal risk for suicide outcomes. We will fulfill the aims of RFA-MH-20-326 and NIH Strategic Objective 2.2 by investigating longitudinal relationships of the RDoC domains of Arousal and Regulatory Systems (construct: sleep disturbance) and Cognitive Systems (construct: inhibitory control) at multiple units of analysis (units: behavioral, self-report, paradigm) on a daily timescale over a 21-day period. This study will be conducted with a transdiagnostic, economically disadvantaged, high- risk sample of diverse young adults (ages 18-34), consistent with NIH’s call to identify biomarkers that predict suicide outcomes across diverse populations.

项目概要/摘要 自杀是美国 18-34 岁年轻人的第二大死因。有一个 迫切需要确定可预测不同人群自杀风险的临床相关行为因素 人群，以及确定这些因素带来风险的机制。睡眠不安有 被确定为自杀结果的近端风险因素，包括意念和企图。重要的是， 睡眠是可以改变的，这使其成为研究关注的重点。拟议的研究将利用每日日记 以及 21 天的体动记录法来检查睡眠障碍的影响——一种特定的、 年轻人自杀结果的可改变的、直接最近的危险因素——第二天自杀 构想和尝试行为。此外，我们将研究抑制控制作为一种时变机制 日常睡眠障碍可能会带来自杀结果的近端风险。我们将实现以下目标 RFA-MH-20-326 和 NIH 战略目标 2.2 通过调查 RDoC 的纵向关系 唤醒和调节系统（构造：睡眠障碍）和认知系统（构造：睡眠障碍）领域 每日时间尺度上多个分析单元（单元：行为、自我报告、范式）的抑制控制） 在 21 天的时间内。这项研究将在跨诊断、经济弱势、高 不同年轻人（18-34 岁）的风险样本，与 NIH 呼吁识别预测的生物标志物一致 不同人群的自杀结果。