Complications of Chronic Viral Infections

描述(由申请人提供)：这项申请的目标是扩大我的指导，医学生，博士后研究员，和初级教员在进行以患者为中心的研究。我的职业生涯一直致力于在慢性病毒感染并发症领域进行高质量的以患者为导向的研究，重点是艾滋病毒疾病。作为优秀导师和培训的接受者，包括临床调查博士，我致力于培训下一代临床调查人员。我在艾滋病毒及其治疗的代谢并发症领域的长期研究，以及最近在巴西对另一种慢性逆转录病毒感染HTLV-1感染的研究，具体目标如下：1)调查艾滋病毒疾病及其治疗的代谢并发症；2)调查丙型肝炎病毒/艾滋病毒混合感染的代谢并发症；以及3)描述HTLV-1感染的临床表现。 由NIAID的补充材料R01-DK065515和艾滋病临床试验小组资助的具体临床研究项目，加上出色的制度环境和教育资源，将使我能够培训下一代研究人员进行高质量、假设驱动、以患者为导向的研究。此外，福格蒂国际中心的支持和T32培训补助金将提供源源不断的高质量国内和国际学员。这份申请描述了一份详细的学员指导计划，其中包括K30临床研究硕士项目，我为该项目开发并共同指导了一门临床试验课程。在我职业生涯的这一关头，K24奖项提供的保护时间对于我扩大国内和国际临床研究计划和指导活动至关重要。到目前为止，我已经能够使用我的方法论技能来提高以患者为导向的研究的质量，这是美国国立卫生研究院资助的康奈尔-巴伊亚热带疾病研究长期合作的一部分。K24奖将使我能够加强与巴西巴伊亚联邦大学的同事们的合作，帮助设计、实施和分析以患者为导向的对公共卫生具有重要意义的热带疾病的研究，包括HTLV-1感染。

DESCRIPTION (provided by applicant): The goal of this application is to expand my mentoring of medical students, post-doctoral fellows, and junior faculty in the conduct of patient-oriented research. My career has been devoted to conducting high quality patient-oriented research in the area of complications of chronic viral infections, with a focus on HIV disease. As the recipient of outstanding mentoring and training, including a PhD in Clinical Investigation, I am committed to training the next generation of clinical investigators. My longstanding research in the area of metabolic complications of HIV and its therapy and recent research in another chronic retroviral infection, HTLV-1 infection in Brazil, as detailed in the following specific aims, will serve as vehicles for training clinical investigators domestically and internationally: 1) To investigate metabolic complications of HIV disease and its therapy; 2) To investigate metabolic complications of HCV/HIV co-infection; and, 3) To characterize the clinical manifestations of HTLV-1 infection. Specific clinical research projects that are funded by R01-DK065515, a supplement from NIAID, and the AIDS Clinical Trials Group, in conjunction with an outstanding institutional environment and resources for education, will enable me to train the next generation of investigators in high quality, hypothesis-driven, patient-oriented research. Furthermore, support from the Fogarty International Center and a T32 training grant will provide a steady stream of high quality domestic and international trainees. This application describes a detailed mentoring plan for trainees, which includes the K30 Masters in Clinical Investigation program for which I developed and co-direct a Clinical Trials course. At this juncture in my career, the protected time afforded by a K24 award is critical to allow me to expand my domestic and international clinical research programs and mentoring activities. To date, I have been able to use my methodologic skills to improve the quality of patient-oriented research being conducted as part of the longstanding NIH-funded Cornell-Bahia collaboration in tropical diseases research. The K24 award will permit me to increase collaborations with colleagues at the Federal University of Bahia in Brazil, assisting in the design, conduct, and analysis of patient-oriented research in neglected tropical diseases of public health importance, including HTLV-1 infection.