Complications of Chronic Viral Infections

慢性病毒感染的并发症

• 批准号: 8287087
• 负责人: MARSHALL J GLESBY
• 金额: $ 18.4万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8287087
• 关键词: AIDS clinical trial group; Area; Blood Banks; Brazil; Chronic; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Commit; Cross-Sectional Studies; Diabetes Mellitus; Disease; Doctor of Philosophy; Double-Blind Method; Education; Environment; Faculty; Fatty acid glycerol esters; Funding; Genotype; Goals; Grant; HIV; HIV-1; Hepatitis C virus; Homocysteine; Homocystine; Human T-lymphotropic virus 1; Infection; Insulin Resistance; International; Medial; Medical Students; Mentors; Metabolic; Mid-Career Clinical Scientist Award (K24); National Institute of Allergy and Infectious Disease; Natural History; Newly Diagnosed; Oxidative Stress; Patients; Pilot Projects; Pioglitazone; Plasma; Postdoctoral Fellow; Protocols documentation; Public Health; Randomized; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Resources; Ribavirin; Stream; Thick; Time; Training; Tropical Disease; United States National Institutes of Health; Universities; Virus Diseases; Visceral; Woman; base; career; design; improved; in vivo; international center; member; neglect; next generation; patient oriented research; placebo controlled study; programs; r-hGH-M; rosiglitazone; skills

DESCRIPTION (provided by applicant): The goal of this application is to expand my mentoring of medical students, post-doctoral fellows, and junior faculty in the conduct of patient-oriented research. My career has been devoted to conducting high quality patient-oriented research in the area of complications of chronic viral infections, with a focus on HIV disease. As the recipient of outstanding mentoring and training, including a PhD in Clinical Investigation, I am committed to training the next generation of clinical investigators. My longstanding research in the area of metabolic complications of HIV and its therapy and recent research in another chronic retroviral infection, HTLV-1 infection in Brazil, as detailed in the following specific aims, will serve as vehicles for training clinical investigators domestically and internationally: 1) To investigate metabolic complications of HIV disease and its therapy; 2) To investigate metabolic complications of HCV/HIV co-infection; and, 3) To characterize the clinical manifestations of HTLV-1 infection. Specific clinical research projects that are funded by R01-DK065515, a supplement from NIAID, and the AIDS Clinical Trials Group, in conjunction with an outstanding institutional environment and resources for education, will enable me to train the next generation of investigators in high quality, hypothesis-driven, patient-oriented research. Furthermore, support from the Fogarty International Center and a T32 training grant will provide a steady stream of high quality domestic and international trainees. This application describes a detailed mentoring plan for trainees, which includes the K30 Masters in Clinical Investigation program for which I developed and co-direct a Clinical Trials course. At this juncture in my career, the protected time afforded by a K24 award is critical to allow me to expand my domestic and international clinical research programs and mentoring activities. To date, I have been able to use my methodologic skills to improve the quality of patient-oriented research being conducted as part of the longstanding NIH-funded Cornell-Bahia collaboration in tropical diseases research. The K24 award will permit me to increase collaborations with colleagues at the Federal University of Bahia in Brazil, assisting in the design, conduct, and analysis of patient-oriented research in neglected tropical diseases of public health importance, including HTLV-1 infection.

描述（由申请人提供）：此应用程序的目标是扩大我的指导医学生，博士后研究员和初级教师在病人为导向的研究进行。我的职业生涯一直致力于在慢性病毒感染并发症领域进行高质量的以患者为导向的研究，重点是艾滋病。作为优秀的指导和培训的接受者，包括临床研究博士学位，我致力于培训下一代临床研究者。我在HIV代谢并发症及其治疗领域的长期研究以及最近在巴西另一种慢性逆转录病毒感染HTLV-1感染方面的研究，如以下具体目标所详述，将作为培训国内和国际临床研究人员的工具：1）研究HIV疾病及其治疗的代谢并发症; 2）研究HCV/HIV合并感染的代谢并发症; 3）描述HTLV-1感染的临床表现。 由R 01-DK 065515（NIAID的补充）和艾滋病临床试验组资助的特定临床研究项目，以及出色的机构环境和教育资源，将使我能够在高质量，假设驱动，以患者为导向的研究中培训下一代研究人员。此外，Fogarty国际中心的支持和T32培训赠款将为高质量的国内和国际学员提供源源不断的培训。此应用程序描述了一个详细的指导计划的学员，其中包括K30硕士临床研究计划，我开发和共同指导临床试验课程。在我职业生涯的这个关键时刻，K24奖项所提供的受保护的时间对于我扩大国内和国际临床研究项目和指导活动至关重要。到目前为止，我已经能够利用我的方法学技能，以提高质量的病人为导向的研究正在进行的长期NIH资助的康奈尔-巴伊亚热带疾病研究合作的一部分。K24奖将使我能够增加与巴西巴伊亚联邦大学同事的合作，协助设计，实施和分析以患者为导向的研究被忽视的热带疾病的公共卫生重要性，包括HTLV-1感染。

项目成果

Pathogenesis and treatment of HIV lipohypertrophy.

• DOI: 10.1097/qco.0b013e3283420eef
• 发表时间: 2011-02
• 期刊: Current opinion in infectious diseases
• 影响因子: 3.9
• 作者: Leung VL;Glesby MJ
• 通讯作者: Glesby MJ

Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection.

• DOI: 10.1002/jmv.23341
• 发表时间: 2012-11
• 期刊: JOURNAL OF MEDICAL VIROLOGY
• 影响因子: 12.7
• 作者: Santos, Silvane Braga;Oliveira, Paulo;Luna, Tania;Souza, Anselmo;Nascimento, Marcia;Siqueira, Isadora;Tanajura, Davi;Muniz, Andre Luiz;Glesby, Marshall J.;Carvalho, Edgar M.
• 通讯作者: Carvalho, Edgar M.

Testosterone replacement therapy and polycythemia in HIV-infected patients.

HIV 感染患者的睾酮替代疗法和红细胞增多症。

• DOI: 10.1097/qad.0b013e32834db446
• 发表时间: 2012
• 期刊: AIDS (London, England)
• 作者: Vorkas,CharlesKyriakos;Vaamonde,CarlosM;Glesby,MarshallJ
• 通讯作者: Glesby,MarshallJ

Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil.

巴西巴伊亚流行区曼氏血吸虫感染抵抗力的相关因素。

• DOI: 10.4269/ajtmh.2012.11-0204
• 发表时间: 2012
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Oliveira,RicardoR;Figueiredo,JoanemileP;Cardoso,LucianaS;Jabar,RafaelL;Souza,RobsonP;Wells,MartinT;Carvalho,EdgarM;Fitzgerald,DanielW;Barnes,KathleenC;Araújo,MariaIlma;Glesby,MarshallJ
• 通讯作者: Glesby,MarshallJ

The role of human T cell lymphotrophic virus type 1, hepatitis B virus and hepatitis C virus coinfections in leprosy.

人类 T 细胞淋巴病毒 1 型、乙型肝炎病毒和丙型肝炎病毒混合感染在麻风病中的作用。

• DOI: 10.1590/s0074-02762012000900008
• 发表时间: 2012
• 期刊: Memorias do Instituto Oswaldo Cruz
• 影响因子: 2.8
• 作者: Machado,PauloRobertoLima;Johnson,WarrenD;Glesby,MarshallJ
• 通讯作者: Glesby,MarshallJ