Nuclear Receptor Function in Hepatic Pathology
Nuclear Receptor Function in Hepatic Pathology
批准号:
7350611
负责人:
DAVID D MOORE
金额:
$33.12万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-08-01 至 2012-07-31
关键词:
AcetaminophenAreaCholestasisCirrhosisClassClinicalDiclofenacDiseaseFastingGenetic TranscriptionGenomicsHepaticHepatocyteHepatotoxicityHumanLiverMetabolicMetabolic DiseasesMicroRNAsMusNuclear ReceptorsPathologyPatientsPharmaceutical PreparationsPhaseRangeReactionReceptor ActivationRoleSamplingScreening procedureSignal TransductionStagingSystems BiologyTechnologyTestingTimebasedrug metabolismmouse modelnonalcoholic steatohepatitisreceptor expressionreceptor functionresponsetherapeutic targettroglitazonetype I and type II diabetes
中文摘要
与该项目特别相关的两个特定领域是筛选代谢信号的影响
英文摘要
Two specific areas with particular relevance to this project arescreening for the impact of metabolic signals
and metabolic disease on hepatic expression of microRNAs, and the role of NRs and their targets in adverse
drug reactions. This project is based on two general hypotheses: 1) Micro RNA expression is altered in
response to nuclear receptor activation and other metabolic signals in the liver, allowing non-proliferative
hepatocytes to alter their function over time. 2) The induction of hepatotoxicity in adverse drug reactions is
associated with large scale alterations in expression of NRs, their coregulators and downstream metabolic
targets, and distinct classes of hepatotoxic agents elicit distinct responses. We will test both hypotheses by
leveraging the ongoing high throughput QPCR screening technologies developed by this Strand in the initial
Phase of the NURSA project.
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科研奖励(0)
会议论文
Project 2: Coordinate regulation of liver energy balance by PPARalpha/SRC-1 and FXR/SRC-2
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批准号:10421283
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项目类别:
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资助金额:$35.66万
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财政年份:2018
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负责人:DAVID D MOORE
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依托单位:
Project 2: Coordinate regulation of liver energy balance by PPARalpha/SRC-1 and FXR/SRC-2
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批准号:10153761
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项目类别:
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资助金额:$35.66万
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财政年份:2018
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负责人:DAVID D MOORE
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依托单位:
Function of the Nuclear Receptor LRH-1
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批准号:7632978
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项目类别:
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资助金额:$38.38万
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财政年份:2009
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负责人:DAVID D MOORE
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依托单位:
Function of the Nuclear Receptor LRH-1
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批准号:7895885
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项目类别:
-
资助金额:$38.38万
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财政年份:2009
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负责人:DAVID D MOORE
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依托单位:
Functions of the Nuclear Receptor SHP
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批准号:7030908
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项目类别:
-
资助金额:$44.12万
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财政年份:2005
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负责人:DAVID D MOORE
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依托单位:
Functions of the Nuclear Receptor SHP
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批准号:7210533
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项目类别:
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资助金额:$44.13万
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财政年份:2005
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负责人:DAVID D MOORE
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依托单位:
Functions of the Nuclear Receptor SHP
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批准号:6925670
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项目类别:
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资助金额:$43.87万
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财政年份:2005
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负责人:DAVID D MOORE
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依托单位:
Functions of the Nuclear Receptor SHP
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批准号:7408571
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项目类别:
-
资助金额:$44.54万
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财政年份:2005
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负责人:DAVID D MOORE
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依托单位:
Metabolic Regulation by the Nuclear Receptor CAR
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批准号:7003683
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项目类别:
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资助金额:$31.6万
-
财政年份:2003
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负责人:DAVID D MOORE
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依托单位:
Metabolic Regulation by the Nuclear Receptor CAR
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批准号:6567797
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项目类别:
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资助金额:$32.36万
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财政年份:2003
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负责人:DAVID D MOORE
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依托单位:
Metabolic Regulation by the Nuclear Receptor CAR
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批准号:6833952
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项目类别:
-
资助金额:$32.36万
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财政年份:2003
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负责人:DAVID D MOORE
-
依托单位:
Metabolic Regulation by the Nuclear Receptor CAR
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批准号:6721370
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项目类别:
-
资助金额:$32.36万
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财政年份:2003
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负责人:DAVID D MOORE
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依托单位:
Function of SHP
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批准号:6589548
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项目类别:
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资助金额:$17.72万
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财政年份:2002
-
负责人:DAVID D MOORE
-
依托单位:
SRC-2 Mediates the Preventative Effects of LRH-1 for NASH in Metabolic Disease
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批准号:8545165
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项目类别:
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资助金额:$34.29万
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财政年份:2001
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负责人:DAVID D MOORE
-
依托单位:
Function of SHP
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批准号:6452764
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项目类别:
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资助金额:$17.72万
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财政年份:2001
-
负责人:DAVID D MOORE
-
依托单位:
SRC-2 Mediates the Preventative Effects of LRH-1 for NASH in Metabolic Disease
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批准号:8856211
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项目类别:
-
资助金额:$35.35万
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财政年份:2001
-
负责人:DAVID D MOORE
-
依托单位:
SRC-2 Mediates the Preventative Effects of LRH-1 for NASH in Metabolic Disease
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批准号:8419648
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项目类别:
-
资助金额:$35.35万
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财政年份:2001
-
负责人:DAVID D MOORE
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依托单位:
ORPHAN RECEPTORS IN ORGANOGENESIS
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批准号:6915468
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项目类别:
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资助金额:$8.28万
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财政年份:2000
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负责人:DAVID D MOORE
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依托单位:
Function of SHP
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批准号:6324284
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项目类别:
-
资助金额:$17.72万
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财政年份:2000
-
负责人:DAVID D MOORE
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依托单位:
ORPHAN RECEPTORS IN ORGANOGENESIS
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批准号:6090344
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项目类别:
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资助金额:$106.34万
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财政年份:2000
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负责人:DAVID D MOORE
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依托单位:
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