Avian Influence Cooperative Research Centers-Human-Animal Inferface

描述（申请人提供）：明尼苏达大学（UMN）和美国上中西部和泰国的合作伙伴提议建立一个国际合作人畜共患流感研究中心（ICZIRC）。该中心与CDC密切合作，将在3年内开展人-动物界面研究，以更好地了解甲型流感病毒的流行病学及其对人类健康的威胁。人类和动物卫生伙伴将密切合作开展研究，以获得以下方面的证据：1）低或高致病性禽流感病毒（AIV）在明尼苏达州和威斯康星州的后院家禽（BYP）中向其看护人传播，以及在聚集在明尼苏达州大都市湖上的野鹅和野鸭中向该湖的娱乐用户传播; 2）猪生产操作中饲养的猪中的猪流感病毒（SIV）传播给猪生产员工; 3） BYP，猪，和泰国农村的其他动物，家庭动物管理员。还将进行研究，以确定环境、行为、畜牧业或其他促进流感病毒从动物传播到人类的因素，以描述由AIV和SIV感染引起的人类疾病，以及4）评估个人防护设备和卫生实践的使用和有效性。这些研究将由一个合作伙伴联盟进行，其中包括UMN公共卫生学院、MN兽医诊断实验室和兽医学院、UMN CIDRAP、马什菲尔德诊所研究基金会、马约诊所、明尼苏达州卫生部（MDH）、MN动物卫生委员会、MN农业部、泰国朱拉隆功大学等。将对采集的动物和人类标本进行检测，以检测、鉴定和表征多种甲型流感病毒以及抗AIV和SIV的抗体。大流行性流感（PI）病毒已经从AIV中出现，获得了感染人类并在人与人之间传播的能力。拟议的研究将解决有关可感染人类的AIV亚型的范围和数量，这些感染发生的机制和频率以及PPE的有效性的重要研究空白。这项研究对于改善PI预防，准备和应对至关重要。

DESCRIPTION (provided by applicant): The University of Minnesota (UMN) and collaborating partners in the upper Midwest US and in Thailand, propose to establish an International Cooperative Zoonotic Influenza Research Center (ICZIRC). In close collaboration with CDC, the Center, over 3-years, will conduct studies at the human-animal interface that will lead to a better understanding of the epidemiology of influenza A viruses and the threat they pose to human health. Studies will be conducted by human and animal health partners working closely together to obtain evidence on the prevalence and transmission of 1) low or highly pathogenic avian influenza viruses (AIV) in backyard poultry (BYP) in MN and WI to their caretakers, and in wild geese and ducks congregating on a large MN metropolitan lake to recreational users of the lake; 2) swine influenza viruses (SIV) in swine raised in swine production operations to swine production employees; 3) AIVs, SIVs, and other influenza viruses in BYP, swine, and other animals in rural villages of Thailand, to household animal caretakers. Studies will also be conducted to identify environmental, behavioral, animal husbandry, or other factors facilitating transmission of influenza viruses from animals to humans, to characterize human illness caused by infections with AIVs and SIVs, and 4) to assess the use and effectiveness of personal protective equipment and hygienic practices. These studies will be conducted by a Consortium of partners, which includes the UMN School of Public Health, MN Veterinary Diagnostic Laboratory and College of Veterinary Medicine, UMN CIDRAP, the Marshfield Clinic Research Foundation, Mayo Clinic, the Minnesota Department of Health (MDH), MN Board of Animal Health, MN Department of Agriculture, Chulalongkorn University in Thailand, and others. Animal and human specimens that are collected, will be tested to detect, identify and characterize multiple influenza A viruses and antibodies against AIVs and SIVs. Pandemic influenza (PI) viruses have emerged from AIVs gaining the ability to infect humans and spreading person-to-person. The proposed research will address important research gaps on the range and number of AIV subtypes that can infect humans, the mechanism and frequency with which these infections occur, and the effectiveness of PPE. This research is essential for improved PI prevention, preparedness and response.