Avian Influence Cooperative Research Centers-Human-Animal Inferface

描述(由申请人提供)：明尼苏达大学(UMN)和美国中西部北部和泰国的合作伙伴提议建立国际合作人畜共患病流感研究中心(ICZIRC)。该中心将与疾病控制与预防中心密切合作，在三年内进行人-动物界面的研究，以更好地了解甲型流感病毒的流行病学及其对人类健康的威胁。人类和动物健康伙伴将密切合作，以获得以下证据：1)MN和WI的后院家禽(BYP)中低或高致病性禽流感病毒(AIV)的流行率和传播给它们的照顾者，以及聚集在MN大城市湖泊上的野鹅和鸭子对该湖的娱乐用户；2)在养猪作业中饲养的猪中的猪流感病毒(SIV)，向养猪生产员工传播；3)AIV、SIV和其他流感病毒在MN的一个大城市湖上聚集，向养猪工人传播 BYP，猪和其他动物在泰国的农村村庄，到家庭动物饲养员。还将进行研究，以确定环境、行为、畜牧业或其他促进流感病毒从动物向人类传播的因素，以确定感染AIV和SIV导致的人类疾病的特征，以及4)评估个人防护装备和卫生做法的使用和有效性。这些研究将由一个合作伙伴联盟进行，其中包括UMN公共卫生学院、MN兽医诊断实验室和兽医学院、UMN CIDRAP、马什菲尔德诊所研究基金会、Mayo诊所、明尼苏达州卫生部(MDH)、MN动物卫生委员会、MN农业部、泰国朱拉隆功大学等。收集的动物和人类样本将进行测试，以检测、鉴定和鉴定多种甲型流感病毒以及针对AIV和SIV的抗体。大流行性流感(PI)病毒已经从禽流感病毒中出现，获得了感染人类并在人与人之间传播的能力。拟议的研究将填补关于可感染人类的AIV亚型的范围和数量、这些感染发生的机制和频率以及个人防护措施有效性的重要研究空白。这项研究对于改进PI的预防、准备和应对至关重要。

DESCRIPTION (provided by applicant): The University of Minnesota (UMN) and collaborating partners in the upper Midwest US and in Thailand, propose to establish an International Cooperative Zoonotic Influenza Research Center (ICZIRC). In close collaboration with CDC, the Center, over 3-years, will conduct studies at the human-animal interface that will lead to a better understanding of the epidemiology of influenza A viruses and the threat they pose to human health. Studies will be conducted by human and animal health partners working closely together to obtain evidence on the prevalence and transmission of 1) low or highly pathogenic avian influenza viruses (AIV) in backyard poultry (BYP) in MN and WI to their caretakers, and in wild geese and ducks congregating on a large MN metropolitan lake to recreational users of the lake; 2) swine influenza viruses (SIV) in swine raised in swine production operations to swine production employees; 3) AIVs, SIVs, and other influenza viruses in BYP, swine, and other animals in rural villages of Thailand, to household animal caretakers. Studies will also be conducted to identify environmental, behavioral, animal husbandry, or other factors facilitating transmission of influenza viruses from animals to humans, to characterize human illness caused by infections with AIVs and SIVs, and 4) to assess the use and effectiveness of personal protective equipment and hygienic practices. These studies will be conducted by a Consortium of partners, which includes the UMN School of Public Health, MN Veterinary Diagnostic Laboratory and College of Veterinary Medicine, UMN CIDRAP, the Marshfield Clinic Research Foundation, Mayo Clinic, the Minnesota Department of Health (MDH), MN Board of Animal Health, MN Department of Agriculture, Chulalongkorn University in Thailand, and others. Animal and human specimens that are collected, will be tested to detect, identify and characterize multiple influenza A viruses and antibodies against AIVs and SIVs. Pandemic influenza (PI) viruses have emerged from AIVs gaining the ability to infect humans and spreading person-to-person. The proposed research will address important research gaps on the range and number of AIV subtypes that can infect humans, the mechanism and frequency with which these infections occur, and the effectiveness of PPE. This research is essential for improved PI prevention, preparedness and response.