A VOC Dosimeter Based On A Colorimetric Sensor Array

我们发明了一种非常简单但非常强大的新技术来检测和 挥发性有机物(VOCs)的鉴定：比色传感器阵列。这些都不贵， 基于分析物与金属卟啉等的平衡相互作用的一次性传感器阵列 化学敏感型染料。与人类嗅觉一样，我们的比色传感器阵列使用了大量的 可探测多种化学性质的交叉反应传感器。通过以数字方式监控 根据阵列中每种染料的颜色，我们有一个对挥发性有机物的复合反应的定量测量。 对于这些阵列，化学模式识别非常强大，因为它们具有非常高的 维度。 我们现在正在将这项工作扩展到生物医学应用，具体目标集中在 个人化学剂量仪的研制用于检测、鉴定和定量 环境/工作场所VOCs。我们阵列的灵敏度允许快速检测到极低水平的 最易挥发的毒物。这是一种翻译技术，应该会在工作场所得到实质性的使用 监测化学品暴露情况。 我们在这些领域的努力应该导致(1)分子传感器开发的根本性进展 这种传感器阵列的识别和生物医学应用，(2)开发和改进 快速和连续地识别和定量挥发性化学毒物的技术，以及 最重要的是，(3)用于评估个人挥发性有机化合物的极其便携的设备的原型 曝光；该设备将提供连续的、定量的、可靠的、可重复的、多路测量 具有快速响应(即，秒)的环境暴露，基本上不需要用户干预 用于现场部署和数据捕获。这款自含式、易于使用的设备将被证明是多设备的理想选择 未来使用的优先环境化学品接触点暴露的分析物测量 以人群为基础的不同人群生物医学研究。我们的设备将能够测量分析物 持续集中，基本上不需要用户干预现场部署和数据 捕获，并将能够对中央系统进行实时遥测。

We have invented a very simple, but extremely powerful, new technology for detection and identification of volatile organic compounds (VOCs): colorimetric sensor arrays. These are inexpensive, disposable sensor arrays based on equilibrium interactions of analytes with metalloporphyrins and other chemically responsive dyes. As with human olfaction, our colorimetric sensor arrays use a large number of cross-reactive sensors that probe a wide range of chemical properties. By digitally monitoring the change in color of each dye in the array, we have a quantitative measure of a composite response to volatile organics. Chemometric pattern recognition is extremely powerful with these arrays because of their very high dimensionality. We are now extending this work to biomedical applications, with specific aims focusing on the development of a personal chemical dosimeter for the detection, identification, and quantification of environmental/workplace VOCs. The sensitivity of our arrays permits rapid detection of very low levels of most volatile toxicants. This is a translational technology that should find substantial use in workplace monitoring of chemical exposure. Our efforts in these areas should lead (1) to fundamental advances in sensor development for molecular recognition and biomedical applications of such sensor arrays, (2) development and refinement of technology for the rapid and continuous identification and quantitation of volatile chemical toxicants, and most importantly, (3) prototyping of an extremely portable device for the assessment of personal VOC exposure; this device will provide continuous, quantitative, reliable, reproducible, multiplexed measurement of environmental exposures with rapid response (i.e., seconds) that requires essentially no user intervention for field deployment and data capture. This self-contained, easy-to-use device will prove ideal for multi- analyte measurement of point-of-contact exposures to priority environmental chemicals for use within future population-based biomedical studies of diverse populations. Our device will be able to measure analyte concentrations continuously, will require essentially no user intervention for field deployment and data capture, and will be capable of real-time telemetry to a centralized system.