Risk Factors for Hot Flashes in Mid-Life Women

中年女性潮热的危险因素

• 批准号: 7498483
• 负责人: Jodi A. Flaws
• 金额: $ 53.52万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498483
• 关键词: 3-Hydroxysteroid Dehydrogenases; Acute; Androgen Receptor; Androgens; Androstenedione; Anxiety; Aromatase; Attention; Attenuated; Biological Assay; Blood specimen; Boxing; CYP1A1 gene; CYP1B1 gene; Candidate Disease Gene; Caring; Catechol Estrogens; Catechols; Chills; Condition; Cytochrome P450; Cytochromes; Data; Development; Disease regression; Enzymes; Estradiol; Estriol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Estrone; Event; Face; Failure; Flushing; Funding; Future; Gene Frequency; Genes; Genetic Polymorphism; Genotype; Glucuronides; Goals; Gonadal Steroid Hormones; Heating; Hormones; Hot flushes; Knowledge; Lead; Life; Link; Logistic Regressions; Longitudinal Studies; Measurement; Measures; Mediating; Medical; Menopausal hot flushes; Menopause; Mental Depression; Metabolism; Methods; Modeling; Non obese; Numbers; Obesity; Ovarian; Ovarian Follicle; Palpitations; Pathway interactions; Perimenopause; Phase; Predisposing Factor; Prevention strategy; Principal Investigator; Progesterone; Public Health; Publications; Quality of life; Questionnaires; Radioimmunoassay; Regression Analysis; Reporting; Research Design; Research Personnel; Risk; Risk Factors; Serum; Sex Hormone-Binding Globulin; Side; Skin; Sleep disturbances; Statistical Models; Steroids; Survival Analysis; Sweat; Sweating; Symptoms; Testing; Testosterone; Thinking; Time; Tissues; Transferase; Transvaginal Ultrasound; United States; Upper arm; Visit; Week; Woman; Work; base; case control; cigarette smoking; dehydroepiandrosterone; design; experience; glucuronide; middle age; neutrophil; novel strategies; prevent; programs; receptor; response; sex; steroid hormone receptor

DESCRIPTION (provided by applicant): Hot flashes pose a significant public heath problem because they are the most common perimenopausal symptom reported by women in the United States and the primary reason that women seek medical care during the menopausal transition. Despite the public health importance of hot flashes, little is known about the factors that predispose women to hot flashes. During the previous funding period, new preliminary data were obtained that indicate that obesity increases the risk of perimenopausal hot flashes. Thus, the overall goal of this renewal application is to examine the mechanism by which obesity increases the risk of hot flashes. Specifically, the proposed work will test the hypothesis that obesity is associated with hot flashes through mechanisms that involve early ovarian failure, altered sex steroid hormone levels, and selected genetic polymorphisms in steroidogenic enzymes and steroid hormone receptors. The specific aims are to determine whether: 1) obesity is associated with early ovarian follicle loss and altered levels of sex steroid hormones, 2) obesity is associated with selected polymorphisms in genes that encode enzymes that synthesize and degrade sex steroids and/or receptors that respond to sex steroids, 3) selected polymorph- isms are associated with sex steroid hormone levels, and 4) the association between obesity and hot flashes is mediated by early ovarian follicle loss, altered hormone levels, and/or selected genetic polymorphisms. To complete these aims, obese and non-obese perimenopausal women with and without hot flashes will complete questionnaires, receive transvaginal ultrasounds for measurement of ovarian volume and follicle numbers, and provide blood samples for measurement of selected sex steroid hormones and genetic polymorphisms in steroidogenic enzymes and steroid hormone receptors. Ovarian volume, follicle numbers, sex steroid hormone levels, and the odds of having selected genetic polymorphisms will be compared in obese and non-obese women using appropriate statistical tests. Further, statistical models will be used to determine whether the association between obesity and hot flashes is attenuated by adjustment for ovarian volume, follicle numbers, sex steroid hormone levels, and selected genetic polymorphisms. The results of this study will provide information about risk factors for perimenopausal hot flashes. In turn, this information may be useful for the future development of novel strategies to prevent or treat hot flashes.

描述(申请人提供)：潮热是一个严重的公共健康问题，因为它是美国女性报告的最常见的围绝经期症状，也是女性在更年期过渡期间寻求医疗护理的主要原因。尽管潮热对公众健康很重要，但人们对导致女性潮热的因素知之甚少。在之前的资助期间，获得了新的初步数据，表明肥胖会增加围绝经期潮热的风险。因此，这项更新申请的总体目标是研究肥胖增加潮热风险的机制。具体地说，这项拟议的工作将通过涉及早期卵巢衰竭、性类固醇激素水平改变以及类固醇生成酶和类固醇激素受体的特定遗传多态的机制来检验肥胖与潮热有关的假说。其具体目的是确定：1)肥胖是否与早期卵巢卵泡丢失和性类固醇激素水平改变有关，2)肥胖与编码合成和降解性类固醇和/或对性类固醇反应的受体的酶的基因的选择多态性有关，3)选择的多态性与性类固醇激素水平相关，以及4)肥胖和潮热之间的联系是由卵巢早期卵泡丢失、激素水平改变和/或选择的遗传多态性介导的。为了实现这些目标，有潮热和无潮热的肥胖和非肥胖围绝经期妇女将完成问卷调查，接受经阴道超声检查以测量卵巢体积和卵泡数量，并提供血液样本以测量选定的性类固醇激素以及类固醇激素生成酶和类固醇激素受体的遗传多态。肥胖和非肥胖女性的卵巢体积、卵泡数量、性类固醇激素水平以及选择基因多态的几率将通过适当的统计检验进行比较。此外，统计模型将被用来确定肥胖和潮热之间的联系是否通过调整卵巢体积、卵泡数量、性类固醇激素水平和选定的遗传多态来减弱。这项研究的结果将提供有关围绝经期潮热危险因素的信息。反过来，这些信息可能对未来预防或治疗潮热的新策略的开发有用。